Ascorbic Acid Levels in the Aqueous Humor of Nocturnal and Diurnal Mammals

Reiss, George R.; Werness, P. G.; Zollman, Paul E.; Brubaker, Richard F.

doi:10.1001/archopht.1986.01050170143039

Cited by 108 publications

(64 citation statements)

References 11 publications

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“…The latter observation, i.e. the environmental adaptation, was later confirmed by Reiss et al (1986). They suggested that in diurnal animals ascorbate may play a protective role against light damage in general.…”

mentioning

confidence: 77%

Corneal epithelium and UV‐protection of the eye

Ringvold

1998

Acta Ophthalmologica Scandinavica

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confidence: 77%

Corneal epithelium and UV‐protection of the eye

Ringvold

1998

Acta Ophthalmologica Scandinavica

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“…In comparison to plasma, it was shown to be slightly hypertonic in a number of mammalian species (Benham et al, 1938;Kinsey, 1951;Levene, 1958), except for rhesus monkeys, in which no significant differences were observed (Gaasterland et al, 1979). The greatest differences in aqueous humor when compared to plasma are its lower concentration of protein (200 times less) and higher levels of ascorbate (20-50 times higher) (Reiss et al, 1986). The protein composition in aqueous humor is both quantitatively and qualitatively different from that of plasma.…”

Section: Aqueous Humor: Composition Formation and Dynamicsmentioning

confidence: 96%

A model to measure lymphatic drainage from the eye

Kim

Johnston

Gupta

et al. 2011

Experimental Eye Research

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Intraocular pressure (IOP) is the most important risk factor for glaucoma development and progression. Most anti-glaucoma treatments aim to lower IOP by enhancing aqueous humor drainage from the eye. Aqueous humor drainage occurs via well-characterized trabecular meshwork (TM) and uveoscleral (UVS) pathways, and the recently described ciliary lymphatics.The relative contribution of the lymphatic pathway to aqueous drainage is not known. We developed a sheep model to quantitatively assess lymphatic drainage along with TM and UVS outflows. Following intracameral injection of 125 I-bovine serum albumin (BSA), lymph and blood samples were continuously collected. Lymphatic and TM drainage were quantitatively assessed by measuring 125 I-BSA recovery. This quantitative sheep model enables assessment of relative contributions of lymphatic drainage (1.64% ± 0.89%), TM (68.86% ± 9.27%) and UVS outflows (19.87% ± 5.59%), and may help to better understand the effects of glaucoma agents on outflow pathways.iii DedicationThis thesis is dedicated to my parents and little brother for their love, endless support and encouragement.iv

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“…It is composed of several tissues and structures, including the posterior surface of the cornea, the anterior surface of the iris, the pupil, the pupillary portion of the lens, and peripherally, the sclerocorneal angle, where the trabecular meshwork (TM), the scleral spur, the ciliary body, and the iris root are located. Both vitamin C and glutathione operate in fluid outside the cell and within the cell (Cardoso et al, 1998); the ascorbate content is higher in diurnal than in nocturnal aqueous humor (Reiss et al 1986). Aqueous humor could act as a liquid ultraviolet-light filter for the lens by virtue of the ascorbic acid in the anterior chamber (Ringvold 1980).…”

Section: Oxidative Stress and Trabecular Meshworkmentioning

confidence: 99%