Ascorbic acid nutrition in gastroduodenal disorders.

Cohen, M. M.; Duncan, A.

doi:10.1136/bmj.4.5578.516

Cited by 32 publications

(10 citation statements)

References 19 publications

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“…It is known that patients with peptic ulceration have low ascorbic acid levels (Cohen and Duncan, 1967;Dymock et al, 1967), and it has recently been shown that ascorbic acid levels in stored blood fall rapidly over the first 7 days (McGinn and Hamilton, 1976). Patients with upper gastro-intestinal haemorrhage have been shown previously to have low leucocyte ascorbic acid levels (Russell et al, 1968), and it is possible that some of the increase in mortality and morbidity of the patients in the present series was due to low ascorbic acid levels.…”

Section: Discussionmentioning

confidence: 99%

Effects of haemorrhage upon surgical operations

McGinn

1976

Journal of British Surgery

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The complications of emergency surgery for acute upper gastro-intestinal haemorrhage in 95 patients were compared with those of surgery for non-bleeding benign peptic ulceration in 380 patients. There was a significantly higher number of senior surgeons performing emergency surgery for haemorrhage. There was a significantly higher mortality (10-5 %), wound dehiscence rate (12-6 %) and wound complication rate with re-bleeding (33-7 %) in the post-haemorrhage patients compared with the non-bleeding group (1-3, 1-8 and 11-6 % respectively). There was no significant difference in the incidence of chest infection in the two groups. Mortality and morbidity after haemorrhage were correlated directly with the amount of blood transfused before surgery. Rats were used to study the effect of the removal of 13 % of the blood volume, and its restoration after varying time intervals, upon subsequent wound healing. Abdominal wounds were tested at 7 days for breaking and bursting strength. There was no difference between the wound strength of the control animals and animals which had been bled for 4 minutes before wounding. A significant reduction of wound strength occurred in animals which had been bled for 30-60 minutes before wounding. Prolonged blood loss was associated with deficient wound healing even if blood loss was restored before the wounds were made. Stored blood may be deficient in a factor which is necessary for normal wound healing.

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Section: Discussionmentioning

confidence: 99%

Effects of haemorrhage upon surgical operations

McGinn

1976

Journal of British Surgery

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“…There is a long history relating ascorbic acid status to gastritis [1,2], ulcer disease [3][4][5][6] and risk for gastric cancer [7][8][9]. Epidemiologic reviews have also linked lower dietary ascorbic acid consumption with an increased risk for gastric cancer [10 -12].…”

Section: Introductionmentioning

confidence: 99%

Relation of Serum Ascorbic Acid toHelicobacter pyloriSerology in US Adults: the Third National Health and Nutrition Examination Survey

Simon¹,

Hudes²,

Pérez-Pérez³

2003

Journal of the American College of Nutrition

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Higher serum levels of ascorbic acid were associated with a decreased seroprevalence of H. pylori and of the pathogenic cagA-positive strain of H. pylori among whites. If these associations are related causally and are not the result of residual confounding by factors such as socioeconomic status, ascorbic acid may affect the risk of H. pylori infection and in turn, the risk for peptic ulcer disease and gastric cancer among white Americans.

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“…The groups which have so far been identified as having subnormal vitamin C levels include the elderly (Andrews and Brook, 1966;Dymock, 1970), those with peptic ulceration or previous gastric surgery (Cohen and Duncan, 1967) and patients with rheumatoid arthritis (Rinehart, Greenberg and Baker, 1936;Sahud and Cohen, 1971). As these population groups are likely to be those who subsequently develop frank clinical scurvy, their identification is important.…”

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confidence: 99%

Ascorbic Acid Deficiency in Malignant Diseases: A Clinical and Biochemical Study

Krasner¹,

Dymock²

1974

Br J Cancer

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Summary.-In a study of the vitamin C status of 50 patients with malignant disease, 46 had leucocyte levels less than the lower limit of the normal range (18-50 ,ug/108 W.B.C.) and of these 30 had very low levels (< 12-5 jug/108 W.B.C.). Physical signs compatible with subclinical scurvy were frequently recorded and there was a significant decrease in capillary fragility in those with the lowest levels. Most patients had an inadequate dietary intake of ascorbic acid-containing foods and this was felt to be the major factor in producing the vitamin depletion.

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Ascorbic acid nutrition in gastroduodenal disorders.

Cited by 32 publications

References 19 publications

Effects of haemorrhage upon surgical operations

Effects of haemorrhage upon surgical operations

Relation of Serum Ascorbic Acid toHelicobacter pyloriSerology in US Adults: the Third National Health and Nutrition Examination Survey

Ascorbic Acid Deficiency in Malignant Diseases: A Clinical and Biochemical Study

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