Ascorbic acid protects the toxic effects of aflatoxin B<sub>1</sub> on yak oocyte maturation

Li, Qin; Zhao, Tian; He, Honghong; Niayale, Robert; Ding, Tianyi; Hu, Xuequan; Zhang, Tongxiang; Cui, Yan; Yu, Sijiu

doi:10.1111/asj.13702

Cited by 3 publications

(1 citation statement)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, adding 50 µg/mL Vitamin C to the culture medium protected yak oocytes from the toxic effects of AFB1 exposure. Specifically, 50 µg/mL Vitamin C reduced intra-oocyte ROS levels, repressed early oocyte apoptosis, improved mitochondrial distribution status, and restored actin distribution [38,96].…”

Section: Antioxidantsmentioning

confidence: 97%

Factors Influencing the Maturation and Developmental Competence of Yak (Bos grunniens) Oocytes In Vitro

Mo,

Ma,

Xiong

et al. 2023

Genes

View full text Add to dashboard Cite

The yak (Bos grunniens) is a unique breed living on the Qinghai–Tibet Plateau and its surrounding areas, providing locals with a variety of vital means of living and production. However, the yak has poor sexual maturity and low fertility. High-quality mature oocytes are the basis of animal breeding technology. Recently, in vitro culturing of oocytes and embryo engineering technology have been applied to yak breeding. However, compared to those observed in vivo, the maturation rate and developmental capacity of in vitro oocytes are still low, which severely limits the application of in vitro fertilization and embryo production in yaks. This review summarizes the endogenous and exogenous factors affecting the in vitro maturation (IVM) and developmental ability of yak oocytes reported in recent years and provides a theoretical basis for obtaining high-quality oocytes for in vitro fertilization and embryo production in yaks.

show abstract

Section: Antioxidantsmentioning

confidence: 97%

Factors Influencing the Maturation and Developmental Competence of Yak (Bos grunniens) Oocytes In Vitro

Mo,

Ma,

Xiong

et al. 2023

Genes

View full text Add to dashboard Cite

show abstract

Enhancing porcine oocyte quality and embryo development through natural antioxidants

Feng,

Song,

Lin

et al. 2025

Theriogenology

View full text Add to dashboard Cite

Vitamin C Improves Oocyte In Vitro Maturation and Potentially Changes Embryo Quality in Cattle

Wang,

Liu

et al. 2024

Veterinary Sciences

View full text Add to dashboard Cite

To obtain high-quality bovine oocytes, the effects of vitamin C (VC) on the IVM of bovine oocytes and early embryo development were investigated. The results showed the following. (1) The IVM medium containing 50 µg/mL VC improved the oocyte maturation rate but did not affect the parthenogenetic embryo development. (2) The IVC medium containing 20 µg/mL VC improved the cleavage rate of the IVF embryos and enhanced the mRNA transcriptions of pluripotency gene Oct4, Sox2, Cdx2, and Nanog in the blastocysts but had no effects on the blastocyst rate. (3) Combining supplementation of 50 µg/mL VC in IVM medium + 20 µg/mL VC in IVC medium (named as VC 50/20, similar hereinafter) elevated the cleavage rate of IVF embryos and enhanced the mRNA expressions of Oct4, Sox2, Cdx2, and Nanog in the blastocysts. (4) Combination of VC 0/20 and VC 50/20 enhanced the transcription of anti-apoptotic gene Bcl-2 and VC 50/0 weakened the transcription of pro-apoptotic gene Bax, while VC 0/40 and VC 0/60 increased Bax expression and diminished the Bcl-2/Bax ratio in blastocysts. Together, employing 50 µg/mL VC improves the IVM of bovine oocytes and combination of VC 50/20 potentially changes bovine embryo quality by enhancing the expressions of the pluripotency genes and regulating the expressions of apoptosis-related genes.

show abstract

Ascorbic acid protects the toxic effects of aflatoxin B₁ on yak oocyte maturation

Cited by 3 publications

References 70 publications

Factors Influencing the Maturation and Developmental Competence of Yak (Bos grunniens) Oocytes In Vitro

Factors Influencing the Maturation and Developmental Competence of Yak (Bos grunniens) Oocytes In Vitro

Enhancing porcine oocyte quality and embryo development through natural antioxidants

Vitamin C Improves Oocyte In Vitro Maturation and Potentially Changes Embryo Quality in Cattle

Contact Info

Product

Resources

About

Ascorbic acid protects the toxic effects of aflatoxin B1 on yak oocyte maturation

Cited by 3 publications

References 70 publications

Factors Influencing the Maturation and Developmental Competence of Yak (Bos grunniens) Oocytes In Vitro

Factors Influencing the Maturation and Developmental Competence of Yak (Bos grunniens) Oocytes In Vitro

Enhancing porcine oocyte quality and embryo development through natural antioxidants

Vitamin C Improves Oocyte In Vitro Maturation and Potentially Changes Embryo Quality in Cattle

Contact Info

Product

Resources

About

Ascorbic acid protects the toxic effects of aflatoxin B₁ on yak oocyte maturation