Ascorbic acid-sensitized Au nanorods-functionalized nanostructured TiO2 transparent electrodes for photoelectrochemical genosensing

Bettazzi, Francesca; Laschi, Serena; Voccia, Diego; Gellini, Cristina; Pietraperzia, Giangaetano; Falciola, L.; Pifferi, V.; Testolin, A.; Ingrosso, Chiara; Placido, Tiziana; Comparelli, Roberto; Curri, Maria Lucia; Palchetti, Ilaria

doi:10.1016/j.electacta.2018.04.146

Cited by 31 publications

(11 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The electrical signal was generated by biotinylated alkaline phosphatase and L-ascorbic acid 2-phosphate substrate oxidation producing the electroactive ascorbic acid. The method had an LOD of 2 nM [47]. Another HCR-based method was developed by Xiang et al (2014).…”

Section: +mentioning

confidence: 99%

Nanotechnology in emerging liquid biopsy applications

Kalogianni

2021

Nano Convergence

View full text Add to dashboard Cite

Liquid biopsy is considered as the most attractive alternative to traditional tissue biopsies. The major advantages of this approach lie in the non-invasive procedure, the rapidness of sample collection and the potential for early cancer diagnosis and real-time monitoring of the disease and the treatment response. Nanotechnology has dynamically emerged in a wide range of applications in the field of liquid biopsy. The benefits of using nanomaterials for biosensing include high sensitivity and detectability, simplicity in many cases, rapid analysis, the low cost of the analysis and the potential for portability and personalized medicine. The present paper reports on the nanomaterial-based methods and biosensors that have been developed for liquid biopsy applications. Most of the nanomaterials used exhibit great analytical performance; moreover, extremely low limits of detection have been achieved for all studied targets. This review will provide scientists with a comprehensive overview of all the nanomaterials and techniques that have been developed for liquid biopsy applications. A comparison of the developed methods in terms of detectability, dynamic range, time-length of the analysis and multiplicity, is also provided.

show abstract

Section: +mentioning

confidence: 99%

Nanotechnology in emerging liquid biopsy applications

Kalogianni

2021

Nano Convergence

View full text Add to dashboard Cite

show abstract

“…An electrochemical nucleic acid-based sensor is defined as a device that integrates nucleic acids (natural and biomimetic forms of oligo-and polynucleotides) as the biological recognition element and an electrode as the physicochemical transducer [64]. According to the biomolecular interactions, nucleic acid-based sensors can be classified as affinity biosensors (i.e., genosensors [65][66][67] and aptasensors [68]), catalytic biosensors (i.e., aptazyme-based sensors), and nucleic acid-based sensors for monitoring of chemically-induced DNA structure modification [69][70][71]. The latter configuration allows the evaluation of DNA-molecule interactions and DNA damage assessment [72][73][74].…”

Section: Electrochemical Nucleic Acid-based Sensorsmentioning

confidence: 99%

Label-Free Bioelectrochemical Methods for Evaluation of Anticancer Drug Effects at a Molecular Level

Tadini‐Buoninsegni

Palchetti

2020

Sensors

Self Cite

View full text Add to dashboard Cite

Cancer is a multifactorial family of diseases that is still a leading cause of death worldwide. More than 100 different types of cancer affecting over 60 human organs are known. Chemotherapy plays a central role for treating cancer. The development of new anticancer drugs or new uses for existing drugs is an exciting and increasing research area. This is particularly important since drug resistance and side effects can limit the efficacy of the chemotherapy. Thus, there is a need for multiplexed, cost-effective, rapid, and novel screening methods that can help to elucidate the mechanism of the action of anticancer drugs and the identification of novel drug candidates. This review focuses on different label-free bioelectrochemical approaches, in particular, impedance-based methods, the solid supported membranes technique, and the DNA-based electrochemical sensor, that can be used to evaluate the effects of anticancer drugs on nucleic acids, membrane transporters, and living cells. Some relevant examples of anticancer drug interactions are presented which demonstrate the usefulness of such methods for the characterization of the mechanism of action of anticancer drugs that are targeted against various biomolecules.

show abstract

“…The antibody, immobilized onto the transducer surface, acts as the biorecognition molecule and recognizes the target antigen. PEC immunosensors convert the affinity reaction into a detectable electrical signal, via excitation and charge transfer of a photoactive material upon absorption of light [61,62,63]. PEC detection offers some peculiar advantages of the electrochemical detection, i.e., low cost, simple and easy to miniaturize instrumentation, etc.…”

Section: Immunosensor Development: Practical Tips and New Trendsmentioning

confidence: 99%

Trends and Perspectives in Immunosensors for Determination of Currently-Used Pesticides: The Case of Glyphosate, Organophosphates, and Neonicotinoids

et al. 2019

Self Cite

View full text Add to dashboard Cite

Pesticides, due to their intensive use and their peculiar chemical features, can persist in the environment and enter the trophic chain, thus representing an environmental risk for the ecosystems and human health. Although there are several robust and reliable standard analytical techniques for their monitoring, the high frequency of contamination caused by pesticides requires methods for massive monitoring campaigns that are capable of rapidly detecting these compounds in many samples of different origin. Immunosensors represent a potential tool for simple, rapid, and sensitive monitoring of pesticides. Antibodies coupled to electrochemical or optical transducers have resulted in effective detection devices. In this review, the new trends in immunosensor development and the application of immunosensors for the detection of pesticides of environmental concern—such as glyphosate, organophosphates, and neonicotinoids—are described.

show abstract

Ascorbic acid-sensitized Au nanorods-functionalized nanostructured TiO2 transparent electrodes for photoelectrochemical genosensing

Cited by 31 publications

References 36 publications

Nanotechnology in emerging liquid biopsy applications

Nanotechnology in emerging liquid biopsy applications

Label-Free Bioelectrochemical Methods for Evaluation of Anticancer Drug Effects at a Molecular Level

Trends and Perspectives in Immunosensors for Determination of Currently-Used Pesticides: The Case of Glyphosate, Organophosphates, and Neonicotinoids

Contact Info

Product

Resources

About