Ascorbic acid supplementation attenuates exercise-induced bronchoconstriction in patients with asthma

Tecklenburg, Sandra; Mickleborough, Timothy D.; Fly, Alyce D.; Bai, Yeon; Stager, Joel M.

doi:10.1016/j.rmed.2007.02.014

Cited by 110 publications

(78 citation statements)

References 44 publications

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“…Moreover, exhaled nitric oxide, urinary leukotriene C 4 , D 4 , E 4 and 9α, 1β-prostaglandin F 2 after exercise are downregulated [209]. On the contrary, there are also studies showing no significant effect of vitamin C supplementation on asthma symptoms.…”

Section: Vitamin Cmentioning

confidence: 99%

Asthma in the 21st Century — Unexpected Applications of Ancient Treatments

Pundir¹,

Kulka²

2013

Using Old Solutions to New Problems - Natural Drug Discovery in the 21st Century

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Section: Vitamin Cmentioning

confidence: 99%

Asthma in the 21st Century — Unexpected Applications of Ancient Treatments

Pundir¹,

Kulka²

2013

Using Old Solutions to New Problems - Natural Drug Discovery in the 21st Century

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“…To date, 10 randomized clinical trials (RCTs) compared vitamin C supplementation with placebo for the treatment of adults with mild-to-severe asthma and only 1 of these 10 studies published during the last decade [10,11]. The dosage of vitamin C was varying from 1, 1.5 to 5 g once daily for about 2 weeks to 6 months [10].…”

Section: Vitamin C and Vitamin Ementioning

confidence: 99%

Is there sufficient evidence to support the use of vitamin supplements in the asthmatic patient?

Rezaei

Mahmoudi

et al. 2017

Expert Review of Respiratory Medicine

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“…This has been shown to be valuable in winter sport athletes [46]. Other options, which have been tested in small studies but not validated in larger studies, include salt restricted diets, fish oil, and vitamin C [47][48][49].…”

Section: Treatmentmentioning

confidence: 99%

Dyspneic athlete

Krey

Best

2014

Curr Rev Musculoskelet Med

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Breathing concerns in athletes are common and can be due to a wide variety of pathology. The most common etiologies are exercise-induced bronchoconstriction (EIB) and paradoxic vocal fold movement disorder (PVFMD). Although some patients may have both, PVFMD is often misdiagnosed as EIB, which can lead to unnecessary treatment. The history and physical exam are important to rule out life threatening pulmonary and cardiac causes as well as common conditions such as gastroesophageal reflux disease, sinusitis, and allergic etiologies. The history and physical exam have been shown to be not as vital in diagnosing EIB and PVFMD. Improvement in diagnostic testing with office base spirometry, bronchoprovocation testing, eucapnic voluntary hyperpnea (EVH) and video laryngoscopy are essential in properly diagnosing these conditions. Accurate diagnosis leads to proper management, which is essential to avoid unnecessary testing and save healthcare costs. Also important to the physician treating dyspnea in athletes is knowing regulations on medications, drug testing, and proper documentation needed for certain organizations. The differential diagnosis of dyspnea is broad and is not limited to EIB and PVFMD. Ruling out life threatening cardiac and pulmonary causes with a proper history, physical, and appropriate testing is essential. The purpose of this review is to highlight recent literature on the diagnosis and management of EIB and PVFMD as well as discuss other potential causes for dyspnea in the athlete.

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Ascorbic acid supplementation attenuates exercise-induced bronchoconstriction in patients with asthma

Abstract: Ascorbic acid supplementation provides a protective effect against exercise-induced airway narrowing in asthmatic subjects.

Cited by 110 publications

References 44 publications

Asthma in the 21st Century — Unexpected Applications of Ancient Treatments

Asthma in the 21st Century — Unexpected Applications of Ancient Treatments

Is there sufficient evidence to support the use of vitamin supplements in the asthmatic patient?

Dyspneic athlete

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