ASCUS and AGUS Criteria

Solomon, Diane; Frable, William J.; Vooijs, G. P.; Wilbur, D. C.; Amma, N. Sreedevi; Collins, Robert J.; Davey, Diane D.; Knight, Bryan; Luff, Ronald D.; Meisels, A; Navin, James J.; Rosenthal, Dorothy L.; Sauer, Torill; Stoler, Mark H.; Suprun, H; Yamauchi, Kazuhiro

doi:10.1159/000331531

Cited by 90 publications

(10 citation statements)

References 15 publications

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“…ASCUS is the term used by patholo-gists to denote cellular changes that are more marked than that attributable to reactive changes but that are quantitatively or qualitatively insufficient for a definitive diagnosis of SIL. [10131415] Ten (9.8%) of the Pap smears showed features of ASCUS, with enlargement of the nucleus (to 2.5–3 times the normal intermediate cell nucleus) and a slight increase in the nuclear/cytoplasmic ratio. There was marked variation in nuclear size and shape.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological importance of Papanicolaou smears for the diagnosis of premalignant and malignant lesions of the cervix

Bukhari

Saba

Qamar

et al. 2012

J Cytol

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Background:Premalignant and malignant lesions are not uncommon in Pakistani women, especially in the older age-groupsAim:This study was conducted to determine the clinicopathological importance of conventional Papanicolaou (Pap) smears for the diagnosis of premalignant and malignant lesions of the cervix.Materials and Methods:Pap smears of 1000 women were examined from January 2007 to June 2009. Only cases with neoplastic cytology were included.Results:The overall frequency of normal, inadequate, neoplastic, and infective smears was 50%, 1.8%, 10.2%, and 38.3%, respectively. Most of the patients (67%) were in the postmenopausal age-group, with the mean age being 44.7±15.63 years. The commonest clinical signs/symptoms seen among the 102 patients with neoplastic gynecological lesions were vaginal discharge and abnormal bleeding (93/102;(91.2% and 62/102;60.7%). Of the 102 cases with neoplastic lesions 46 patients (45%) had low-grade squamous cell intraepithelial lesions (LSILs), 22 (21.5%) had high-grade squamous cell intraepithelial lesions (HSILs), 14 (13.7%) had squamous cell carcinoma, and 6 (5.8%) showed features of adenocarcinoma. Ten (9.8%) cases showed cytology of atypical squamous cells of undetermined significance (ASCUS) and four (3.9%) cases had atypical glandular cells of undetermined significance (AGUS).Conclusion:We conclude that cervical smear examination is well suited for diagnosing neoplastic disease. It is clear that cervical neoplastic lesions are becoming a problem in Pakistan.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological importance of Papanicolaou smears for the diagnosis of premalignant and malignant lesions of the cervix

Bukhari

Saba

Qamar

et al. 2012

J Cytol

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“…Secondly, the differential diagnosis of AGC is diverse, as it encompasses a wide spectrum of cellular changes ranging from a variety of benign or reactive processes (75%) to preneoplastic or neoplastic pathology (25%), involving various cell types [2]. Thus, the literature reports AGC as an uncommon interpretation in most laboratories, ranging from 0.18 to 0.74% [3,4]. …”

Section: Introductionmentioning

confidence: 99%

Identification of Atypical Glandular Cells in Pap Smears: Is It a Hit and Miss Scenario?

Ajit¹,

Gavas²,

Joseph³

et al. 2012

Acta Cytologica

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Objective: Glandular cell abnormality (GCA) in Pap smears is uncommon. Detection is important as the possibility of underlying high-grade lesions is greater in this entity than in atypical squamous cells of undetermined significance. This study was undertaken with an aim to correlate GCA cases with histology, scrutinize its mimics and identify cytologic features to segregate significant lesions from benign. Study Design: A total of 22,618 conventional Pap smears were retrospectively analyzed. In all, 74 GCA cases were identified, correlated with histology and reevaluated using parameters based on architectural pattern, cellular features and background. Results: This study revealed 15 false positives. On review, 11 cases [1 adenocarcinoma, 5 atypical glandular cells (AGC), not otherwise specified, 5 AGC, favor neoplasia (FN)] were recategorized as reactive. Of 9 cases reported as cervical intraepithelial neoplasia on histology, cytodiagnosis in 5 was revised from AGC-FN to high-grade squamous intraepithelial lesion involving glands. Initial overall cytohistology concordance was 79.7%. Reevaluation of the smears, based on stringent cytomorphological criteria, enhanced overall agreement to 94.59%. Conclusions: A diagnosis of AGC has considerable clinical implications. Dissociated atypical cells, nuclear membrane, architecture and chromatin pattern are the key distinguishing features between neoplastic and benign lesions.

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“…1 Several different methods of ASCUS risk stratification have been put forth in the recent past, including such designations as ASCUS (favor reactive), ASCUS (favor dysplastic) 2 and, more recently, as part of the International Academy of Cytology consensus conference held in Hawaii in 1997, ASCUS (cannot rule out high grade SIL or low grade SIL [LSIL]). 3 As one might imagine, using the various stratification schemes allows some risk assessment; however, the percentages of follow-up SIL and HSIL cases differs widely between the studies performed. [4][5][6] Therefore, we would make the recommendation that cytologists stratify ASCUS patients into groups where follow-up SIL rates are expected to be different, as Dr. Frankel suggests, but we would not feel comfortable placing specific percentages on SIL association/progression.…”

Section: Drs Sheils and Wilbur Replymentioning

confidence: 99%

Letter to the Editors

1998

Acta Cytologica

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ASCUS and AGUS Criteria

Cited by 90 publications

References 15 publications

Clinicopathological importance of Papanicolaou smears for the diagnosis of premalignant and malignant lesions of the cervix

Clinicopathological importance of Papanicolaou smears for the diagnosis of premalignant and malignant lesions of the cervix

Identification of Atypical Glandular Cells in Pap Smears: Is It a Hit and Miss Scenario?

Letter to the Editors

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