Aseptic Meningitis Followed by Bilateral Optic Neuritis

Abstract

Myelin oligodendrocyte glycoprotein antibody-associated disorder (MOGAD) is a distinct primary demyelinating disorder with an evolving clinical and imaging spectrum. The term MOGAD has been recently coined to describe the neuroinflammatory condition associated with MOG-IgG antibodies. We report an unusual clinical phenotype of aseptic meningitis later followed by bilateral optic neuritis with a distinct gap of 13 months in an adult patient with MOGAD. CaseA 46-year-old man presented with a history of fever, headache, and vomiting of 2-week duration without alteration in sensorium or seizures. Examination revealed that he was conscious, oriented, and had signs of meningeal irritation with no lateralizing or localizing neurologic deficits. The initial fundus examination showed a normal optic disc.