Aseptic meningitis following therapy with immune globulins: a combination of product features and patient characteristics?

Abstract

In contrast to previously published data, AM was observed in both low-dose and high-dose regimens without favoring high IG doses, and females were affected nearly four times more often than males. Immunoglobulin G dimers may play a role in the etiology of AM, and subcutaneous administration may be associated with a lower rate of AM compared with intravenous administration.

Immunoglobulin-Induced Aseptic Meningitis in Juvenile Dermatomyositis: A Case Report

“…It had been suggested that history of migraines, female sex and underlying connective tissue disease such as systemic lupus erythromatosus could be potential risk factors for developing aseptic meningitis after IVIG. 13,14,15 Further evidences are needed to evaluate whether juvenile dermatomyositis could be a risk factor.…”

“…In regard to IVIG-related risk factors, particularly the dosage and the infusion rate, evidence remains disputable. 8, 13 We do not know why some IVIG brands seem to be more likely to cause aseptic meningitis. It was thought that it could possibly be related to the IgA concentration given that the administration of IVIG containing IgA may cause dramatic clinical reactions in patients with serum anti-IgA.…”

“…Corticosteroids do not seem to be effective in treating IVIG-induced aseptic meningitis. 7,12,13 Re-infusions are not contraindicated. 6,16 In case our patient requires IVIG in the future, Privigen TM will be avoided.…”

“…19 Subcutaneous immunoglobulin (SCIG) was associated with lower rates of aseptic meningitis. 20 There are increasing number of studies show that subcutaneous immunoglobulin (SCIG) can be used in treating various diseases including immunode ciency diseases, myasthenia gravis, chronic in ammatory demyelinating polyneuropathy etc. Further research is needed to determine its e ciency as an immunomodulatory therapy.…”

Síndrome de Guillain Barré e hidrocefalia en un lactante con Síndrome de Wiskott Aldrich

“…A pesar de tratarse de una inmunodeficiencia, los trastornos autoinmunes son frecuentes en el SWA, en-El aumento de la proteinorraquia se ha reportado en casos aislados con el uso de inmunoglobulina, siendo secundario a una meningitis aséptica 20 . Pensamos que la hiperpoteinorraquia en este paciente, se explica principalmente por la inflamación radicular propia del SGB.…”