Aseptic surgical preparation for upper eyelid blepharoplasty via full‐face octenidine antiseptic without antibiotic medication shows effective prophylaxis against post‐surgical wound infection

Matiasek, Johannes; Kienzl, Philip; Otti, Gerlinde R.; Turk, Bela R.; Djedovic, Gabriel; Rieger, Ulrich M.

doi:10.1111/iwj.12837

Cited by 12 publications

(7 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Octenidine dihydrochloride (OCT) is a widely used medical antimicrobial agent for preoperative antisepsis of skin and mucosa (Matiasek et al . 2018), as well as wounds and burns (Assadian 2016). The OCT [ N,N '‐(1,10 decanediyldi‐1[4 H ]‐pyridinyl‐4‐ylidene)bis(1‐octanamine)dihydrochloride] molecule belongs to the bipyridines and carries two active cationic centres per molecule.…”

Section: Introductionmentioning

confidence: 99%

Effects of octenidine applied alone or mixed with sodium hypochlorite on eukaryotic cells

et al. 2020

View full text Add to dashboard Cite

AimTo assess the effects of octenidine dihydrochloride (OCT) on eukaryotic cells and the cytotoxicity of OCT associated with sodium hypochlorite – NaOCl (NaOCl/OCT).MethodologyL929 fibroblasts and human osteoblast‐like cells (Saos‐2) were exposed to 0.1% OCT, 2% CHX, 2.5% NaOCl, 5.25% NaOCl and mixtures of 5.25% NaOCl and 0.1% OCT (NaOCl/OCT) at 90 : 10, 80 : 20 and 50 : 50 ratios. Cell viability was assessed by methyl‐thiazol‐tetrazolium (MTT) and neutral red (NR) assays; type of cell death, by flow cytometry; cytoskeleton, by actin and α‐tubulin fluorescence; and alkaline phosphatase (ALP) activity, by thymolphthalein release. The data were analysed by two‐way ANOVA and Bonferroni tests (α = 0.05).ResultsMTT and NR assays revealed that 0.1% OCT had the lowest cytotoxicity (P < 0.05), followed by 2% CHX (P < 0.05). The 2.5% NaOCl, NaOCl/OCT 80 : 20 and NaOCl/OCT 50 : 50 solutions had intermediate cytotoxicity. NaOCl 5.25% and NaOCl/OCT 90 : 10 had the highest cytotoxicity (P < 0.05). The OCT group had a higher percentage of viable cells than the NaOCl and CHX groups (P < 0.05), and induced apoptosis at higher doses. The cytoskeleton alterations were observed at 0.12%, 0.6% and 2.02% for the NaOCl, CHX and OCT groups, respectively. The solutions did not induce ALP activity.ConclusionOctenidine dihydrochloride was less cytotoxic, induced apoptosis at higher doses, caused few changes in the cytoskeleton and did not induce alkaline phosphatase activity. In addition, octenidine dihydrochloride reduced the cytotoxicity of 5.25% NaOCl when combined at 20 and 50%.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of octenidine applied alone or mixed with sodium hypochlorite on eukaryotic cells

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Patients may experience greater comfort in posing inquiries to AI that they may be reluctant to ask a surgeon directly, potentially due to feelings of anxiety or the perceived limitations of time during face-toface consultations. [19,33] However, the AI model's constraints are apparent in its capacity to uphold prejudices and preconceived notions, as demonstrated in numerous prior investigations. [34,35] This poses a substantial issue in healthcare environments where objectivity and precision are vital.…”

Section: Discussionmentioning

confidence: 99%

Artificial Intelligence in Patient Care: A Study of Artificial Intelligence’s Responses to Blepharoplasty Concerns

Yassa,

Ayad,

Patel

et al. 2024

Preprint

View full text Add to dashboard Cite

Purpose Artificial Intelligence (AI) is rapidly advancing and profoundly influencing healthcare, offering the potential to revolutionize access to medical information. As medical misinformation proliferates and online searches for health-related advice increase, there is an escalating need for dependable patient information. This study evaluates the effectiveness of an AI chatbot in delivering information for blepharoplasty candidates. Materials and Methods Numerous frequently asked questions on blepharoplasty sourced from the ASPS website were asked to ChatGPT. The responses were then rigorously cross-referenced with relevant scholarly literature and meticulously reviewed by the research team to determine their accuracy. Additionally, the questions were classified into three categories, and the responses were evaluated using Flesch-Kincaid readability metrics, along with ANOVA and trend analysis tests. Results Despite minor variations, ChatGPT's responses to blepharoplasty FAQs largely aligned with current literature. Overall readability analysis showed a Flesch Reading Ease score of 31.48, indicating high school complexity with a Flesch-Kincaid Grade Level at 10.92, and 20.97% use of passive voice. The ANOVA results showed that there were no significant differences in readability between the categories (p-values: Flesch Reading Ease = 0.816, Flesch-Kincaid = 0.616, Passive Sentences = 0.115). Trend analysis also showed that the level of response complexity stayed the same across the questions. Conclusion ChatGPT is an evolving tool that holds potential for patients in accessing and comprehending medical information. While it can offer accurate insights, it's important to recognize that its answers might not consistently reach complete accuracy or be suitable for patients with varying educational levels.

show abstract

“…It is useful for both skin and mucous membrane disinfection and is well tolerated. 47 It has a rapid effect and a broad antiseptic spectrum, for MRSA, chlamydia trachomatis, pseudomonas aeruginosa, neisseria gonorrhoeae, gardnerella vaginalis, candida albicans, and trichomonas.…”

Section: Discussionmentioning

confidence: 99%

An Algorithm for Prevention of Unsightly Facial Scars Considering the Newest Research Insights

Feinendegen

Grubnik

Feinendegen³

2022

Plastic and Reconstructive Surgery - Global Open

View full text Add to dashboard Cite

Background: Unsightly scars after facial surgery might be a worry for patients and surgeons alike. To prevent unfavorable scars after facial operations, it is inevitable for the surgeon to adhere to different principles and to follow an algorithm: patient assessment, incision planning, surgical technique, suture material, and postoperative scar management. A defined knowledge about the pathophysiology of wound healing is required. The aim of this report is to serve as a teaching purpose and to verify the well-known empirical practices in scar prevention with the corresponding explanatory research. Based on these findings, the suggestion of an appropriate algorithm for the best scar management will be elaborated. Methods: This article elucidates the basics of unsightly scar prevention and the concomitant scientific proofs in detail by reviewing the literature and newest research published in PubMed. Results: The preoperative, intraoperative, and postoperative guidelines for the achievement of acceptable facial scars will be distinguished regarding the valid state of knowledge. Special attention is drawn to the “flat incision technique” as the first surgical step. Based on the newest research, an algorithm of the important preoperative, intraoperative, and postoperative features to achieve scar improvement is presented. Conclusions: To prevent unsightly facial scars, a well-defined algorithm must be followed. In summary, three well-established, empirically proven measures are documented now by the equivalent physiological scientific proof: (1) the flat incision technique, (2) the wound closure with maximal tension reduction, and (3) the postoperative scar management with further tension reduction and more moisturizing of the scar.

show abstract

Aseptic surgical preparation for upper eyelid blepharoplasty via full‐face octenidine antiseptic without antibiotic medication shows effective prophylaxis against post‐surgical wound infection

Cited by 12 publications

References 21 publications

Effects of octenidine applied alone or mixed with sodium hypochlorite on eukaryotic cells

Effects of octenidine applied alone or mixed with sodium hypochlorite on eukaryotic cells

Artificial Intelligence in Patient Care: A Study of Artificial Intelligence’s Responses to Blepharoplasty Concerns

An Algorithm for Prevention of Unsightly Facial Scars Considering the Newest Research Insights

Contact Info

Product

Resources

About