Asherman syndrome—one century later

Yu, Dan; Wong, Yat May; Cheong, Ying; Xia, Enlan; Li, Tin‐Chiu

doi:10.1016/j.fertnstert.2008.02.096

Cited by 687 publications

(631 citation statements)

References 109 publications

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“…Menstrual disorders, chronic pelvic pain, recurrent pregnancy loses and infertility are some of these clinical problems frequently associated with AS. Menstrual disorders are often expressed as amenorrhea, hypomenorrhea, or dysmenorrhea depending on the extent of disease and amount of adhesions in the uterine cavity [3].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of stem cell application on Asherman Syndrome, an experimental rat model

Kılıç

Yüksel

Pınarlı³

et al. 2013

Fertility and Sterility

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Section: Introductionmentioning

confidence: 99%

“…The aim of the surgery is to restore the shape of the uterine cavity [5]. In some instances, such as dense scar tissue and difficult entry to the cervix, a simultaneous laparoscopic guidance may be required to provide safety and reduce the risk of uterine perforation [3].…”

Section: Introductionmentioning

confidence: 99%

Effect of stem cell application on Asherman Syndrome, an experimental rat model

Kılıç

Yüksel

Pınarlı³

et al. 2013

Fertility and Sterility

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“…It is linked on the one hand, to the presence of mechanical obstacle: the occlusion of the tubal ostia, and / or the complete stenosis of the uterine cavity, or of the cervical canal, can impede the migration of the spermatozoa and the implantation of the egg. 19 On the other hand, the alteration of the adjacent endometrium by lack of hormonal receptivity as well as its vascular degradation prevents the proper course of implantation and placentation. In uterine synechiae, menstrual disorders dominated by amenorrhea, oligomenorrhea, and hypomenorrhea are common, and usually after infertility, constitute the second circumstance of discovery of synechia.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic, therapeutic and prognostic aspects of uterine synechiae managed by hysteroscopy in the gyanecological endoscopic surgery and human reproductive teaching hospital

Belinga

Tompeen

Ndoua

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: Uterine synechiae refers to a total or partial union of the inner walls of the uterus resulting from endometrial trauma. It is a cause of reproductive failure. Until now, synechia was not optimally treated and has remained understudied in Cameroon. Objective of present study was to Evaluate the diagnostic, therapeutic and prognostic aspects of uterine synechiae treated by hysteroscopy.Methods: We conducted a descriptive cross-sectional study with an analytical component from January 1st 2015 to July 31st 2017 at Yaounde. All patients diagnosed with uterine synechiae and treated with hysteroscopy were our sample. Sampling was consecutive. The chi-square test was used for the comparison of qualitative variables and Fisher's test for ANOVA variance analysis. The comparison of the averages was made by the Student's test. P-value less than 0.05 was considered as statistically significant.Results: Hysteroscopies were indicated for uterine synechiae in 14.50%. Nulliparous were 56.67%. A history of curettage/aspiration was present in 66.66%. All of the patients had a form of infertility and 83.33% had menstrual disorders. Hysterosalpingography showed a better sensitivity (88%). After hysteroscopic treatment, 63.30% had a complete anatomical restitution. There is a significant correlation between the stage of severity of synechia and anatomical restitution (p=0.008; Spearman correlation coefficient=-0.477).Conclusions: Uterine synechiae represent one-sixth of all indications for hysteroscopy and present clinically as menstrual disorder associated with infertility. A past history of uterine curettage is common. Hysterosalpingography has a better preoperative diagnostic sensitivity. Hysteroscopy allows optimal treatment.

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“…The functional layer sloughs and renews in a cyclic manner with menstrual period, whereas the regeneration occurs exclusively in the basal layer 1. Any damage related to the basal layer of endometrium severely causes epithelial regenerative disorders, scar formation, fibrosis, intrauterine adhesion (IUA) and consequently engenders amenorrhoea and infertility 2. The mainstream clinical remedies include adhesiolysis under hysteroscope with adjuvant oestrogen therapy and post‐surgery placement of intrauterine device or balloon‐expandable stents, which manifests certain curative effect for the mild and moderate cases 3.…”

Section: Introductionmentioning

confidence: 99%

Transplant of insulin‐like growth factor‐1 expressing bone marrow stem cells improves functional regeneration of injured rat uterus by NF‐κB pathway

Wang

Yang

Jin

et al. 2018

J Cellular Molecular Medi

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To investigate the potential beneficial effect of insulin‐like growth factor‐1 (IGF‐1) in BMSC transplantation therapy of uterus injury and the underlying molecular mechanisms, rat BMSCs were isolated and cultured. The relative expressions of IGF‐1 and IL‐10 were determined by RT‐PCR and immunoblotting. The secretory IL‐10 and released E2 were measured using ELISA kits. The relative vWF and α‐SMA expressions were determined by immunohistochemistry. The direct binding of NF‐κB subunit p50 with IL‐10 promoter was analysed by chromatin immunoprecipitation assay. The regulation of IL‐10 expression by p50 was interrogated by luciferase reporter assay. Our data demonstrated that IGF‐1 expression in BMSCs induced IL‐10 expression and secretion, which was further enhanced by E2‐PLGA. IGF‐1 overexpression improved BMSCs transplantation therapy in rat uterus injury. We further demonstrated that both inhibition and knockdown of p50 abolished IGF‐1‐induced expression and secretion of IL‐10 in BMSCs, which consequently compromised the IGF‐1 conferred therapeutic benefits against uterus injury. Furthermore, we elucidated that p50 regulated IL‐10 expression via direct association with its promoter. Our data suggested that transplantation of IGF‐1 overexpressing BMSCs improved functional regeneration of injured uterus by inducing IL‐10 expression and secretion via activation of NF‐κB signalling.

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Asherman syndrome—one century later

Cited by 687 publications

References 109 publications

Effect of stem cell application on Asherman Syndrome, an experimental rat model

Effect of stem cell application on Asherman Syndrome, an experimental rat model

Diagnostic, therapeutic and prognostic aspects of uterine synechiae managed by hysteroscopy in the gyanecological endoscopic surgery and human reproductive teaching hospital

Transplant of insulin‐like growth factor‐1 expressing bone marrow stem cells improves functional regeneration of injured rat uterus by NF‐κB pathway

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