Abstract-The lead concentrations in muscles and carapace of white shrimp (Litopenaeus vannamei) fromPaliyan village, Temon district, Kulon Progo county, Yogyakarta Special Province in Indonesia and those of tiger shrimp (Penaeus monodon) bought in a grocery store in Yogyakarta were determined and compared to assses bioaccumulation and food safety.Ten samples of 40-day-old white shrimp composites (n=8), ten samples of 60-day-old White shrimp composites (n =5), ten samples of 80 day-old white shrimp composites (n=5), and ten samples of tiger shrimp composites (n=2) were collected and analyzed for Pb concentrations using Atomic Absorption Spectrophotometer. The mean concentration of Pb in 40-day-old white shrimps were below the detection limit of 0.05 µg/g d.w. No significant differences was found between the mean concentrations of Pb in muscles of 60-day-old (1.71 ± 0.74) and those of 80-day-old (1.84 ± 0.30 µg/g d.w.) white shrimps. However, significant differences (p < 0.05) were found between the mean concentrations of Pb in carapace of 60-day-old (8.22 ± 3.35) and those of 80-day-old (4.55 ± 1.03 µg/g d.w.) white shrimps. The mean of lead concentrations in shrimps in this study (0.25 -0.41 µg/g w.w.) were lower than the recommended limit (0.50 µg/g w.w.). Similarly, the average daily intake of Pb through shrimp consumption was 0.39-13.39 µg/person/day and was relatively lower than the recommended value of 12,86 µg/person/day. Based on the results, it can be concluded that the shrimps analyzed in this study were safe for human consumption.