Asiaticoside Antagonizes Proliferation and Chemotherapeutic Drug Resistance in Hepatocellular Carcinoma (HCC) Cells

Ma, Ying; Wen, Jun; Wang, Jing; Wang, Chunyan; Zhang, Yan; Zhao, Lili; Li, Jia; Xue, Feng

doi:10.12659/msm.924435

Cited by 19 publications

(10 citation statements)

References 39 publications

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“…In other words, AC restrained gastric cancer cell proliferation, migration, and EMT. These findings were in keeping with the reported studies [ 13 – 15 ]. Zhou et al proved that AC inhibited the cell proliferation ability of colorectal cancer cells [ 14 ].…”

Section: Discussionsupporting

confidence: 93%

“…Therefore, it is pressing to discover curative therapeutic strategies against gastric cancer. AC participates in the regulation of some cancers such as multiple myeloma, colorectal cancer, and colorectal cancer [ 13 – 15 ]. Thus, we conjectured that AC may modulate gastric cancer progression.…”

Section: Discussionmentioning

confidence: 99%

“…Zhou et al proved that AC inhibited the cell proliferation ability of colorectal cancer cells [ 14 ]. Ma et al found that AC restrained the proliferation capacity of hepatocellular carcinoma [ 15 ]. AC also inhibited multiple myeloma cell aggressive behaviors [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…Besides, AC alleviates bleomycin-induced pulmonary fibrosis through activation of the Cyclic Adenosine Monophosphate (cAMP) and Ras-proximate-1 (Rap1) signaling pathway [ 11 ]. Recently, the antitumor role of AC in some cancers has emerged [ 12 – 15 ]. Huang et al proved that AC promoted cancer cell apoptosis and strengthened the anticancer activity of vincristine [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…Zhou et al showed that AC inhibited cell proliferation via regulating the NF- κ B pathway in colorectal cancer [ 14 ]. Ma et al demonstrated that AC suppressed cell proliferation and chemotherapeutic drug resistance in hepatocellular carcinoma [ 15 ]. However, the effect of AC on gastric cancer progression remains elusive.…”

Section: Introductionmentioning

confidence: 99%

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Asiaticoside Suppresses Gastric Cancer Progression and Induces Endoplasmic Reticulum Stress through the miR-635/HMGA1 Axis

Zhang

Chen³

et al. 2022

Journal of Immunology Research

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Objective. Gastric cancer is a prevalent malignant tumor with high morbidity and poor prognosis. Asiaticoside (AC) has antitumor effects, while its role in gastric cancer is elusive. Thus, this study investigated the effect of AC on gastric cancer progression. Methods. Cell viability and migration were determined using the CCK-8 and Transwell migration assay. Endoplasmic reticulum stress was detected through measuring the expressions of GRP78, Chop, and hnRNPA1 by Western blot. The luciferase assay confirmed the relationship between miR-635 and High Mobility Group AT-Hook 1 (HMGA1). The effect of AC on tumor growth was evaluated by establishing a xenograft tumor. The survival rate of mice was analyzed by Kaplan-Meier analysis. Results. AC suppressed gastric cancer cell viability and restrained cell migration. AC inhibited the expressions of the cell proliferation marker PCNA and EMT-related marker N-cadherin and increased E-cadherin expression. AC elevated the levels of GRP78 and Chop and suppressed the level of hnRNPA1. In addition, AC restrained gastric cancer proliferation and migration ability and induced endoplasmic reticulum stress by upregulating miR-635 expression. Furthermore, HMGA1 was proven to be a target of miR-635. AC constrained gastric cancer cell proliferation and migration and promoted endoplasmic reticulum stress by regulating HMGA1. Moreover, AC suppressed in vivo tumor growth and improved the survival time of mice. Additionally, AC elevated the expressions of miR-635, E-cadherin, GRP78, and Chop and inhibited Ki-67, HMGA1, N-cadherin, and hnRNPA1 expressions in tumor tissues of mice. Conclusion. AC suppressed gastric cancer progression and induced endoplasmic reticulum stress via the miR-635/HMGA1 axis, providing a valuable drug against gastric cancer.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Asiaticoside Suppresses Gastric Cancer Progression and Induces Endoplasmic Reticulum Stress through the miR-635/HMGA1 Axis

Zhang

Chen³

et al. 2022

Journal of Immunology Research

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Asiaticoside enhances the effect of propofol on the invasion, ferroptosis and immune escape of bladder cancer

Jin,

He,

Zhen

et al. 2024

Drug Development Research

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Bladder cancer is a highly prevalent malignancy. Asiaticoside (AC), a triterpenoid derivative, exhibits antitumor effect on different tumors. This study aimed to explore the role and mechanism of AC on bladder cancer. J82 and T24 cells were treated with AC and/or propofol, and nude mice were subcutaneously administrated with T24 cells. The effect and mechanism of AC and/or propofol were explored by cell counting kit‐8, transwell, flow cytometry, enzyme‐linked immunosorbent assay, immunohistochemistry and western blot assays both in vitro and in vivo. Cell viability of J82 and T24 cells was inhibited by AC with a IC50 value of 2.43 μM and 2.16 μM, and by propofol with a IC50 value of 42.51 μM and 48.37 μM, respectively. AC or propofol alone decreased cell proliferation, invasion, and immune escape with the increased ferroptosis, as well as downregulating the level of the PI3K/AKT pathway in both animal and cell experiments. The effect of propofol on the above‐mentioned indicators was further enhanced with the co‐treatment of AC in vitro and in vivo. Taken together, AC promoted the ameliorative effect of propofol on bladder cancer involved in PI3K/AKT pathway.

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Asiaticoside hampers epithelial–mesenchymal transition by promoting PPARG expression and suppressing P2RX7‐mediated TGF‐β/Smad signaling in triple‐negative breast cancer

Huang

Jia

et al. 2022

Phytotherapy Research

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Triple-negative breast cancer (TNBC) accounts for 10-20% of all human ductal adenocarcinomas and has a poor prognosis relative to other subtypes because of its high propensity to develop metastases. Here, the anticancer effects of asiaticoside (AC) against TNBC and the possible underlying mechanism were examined. We found that AC inhibited the TGF-β1 expression and the SMAD2/3 phosphorylation in TNBC cells, thereby impairing the TGF-β/SMAD signaling. AC inhibited the migration, invasion, and epithelial-mesenchymal transition (EMT) of TNBC cells by suppressing the TGF-β/SMAD signaling. Meanwhile, AC inhibited the lung metastasis of TNBC cells in vivo and the expression of p-SMAD2/3 and vimentin, and increased the expression of E-cadherin and ZO-1 in the lung. Peroxisome proliferator activated receptor gamma (PPARG) was identified as a potential target of AC. AC increased PPARG expression, while PPARG knockdown attenuated the therapeutic effect of AC. AC-mediated PPARG overexpression suppressed the transcription of P2X purinoceptor 7 (P2RX7). The restoration of P2RX7 reversed the therapeutic effect of AC. These results suggested that AC blocked P2RX7-mediated TGF-β/SMAD signaling by increasing PPARG expression, thereby suppressing EMT in TNBC.

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Asiaticoside Antagonizes Proliferation and Chemotherapeutic Drug Resistance in Hepatocellular Carcinoma (HCC) Cells

Cited by 19 publications

References 39 publications

Asiaticoside Suppresses Gastric Cancer Progression and Induces Endoplasmic Reticulum Stress through the miR-635/HMGA1 Axis

Asiaticoside Suppresses Gastric Cancer Progression and Induces Endoplasmic Reticulum Stress through the miR-635/HMGA1 Axis

Asiaticoside enhances the effect of propofol on the invasion, ferroptosis and immune escape of bladder cancer

Asiaticoside hampers epithelial–mesenchymal transition by promoting PPARG expression and suppressing P2RX7‐mediated TGF‐β/Smad signaling in triple‐negative breast cancer

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