Asiaticoside delays senescence and attenuate generation of ROS in UV‑exposure cells through regulates TGF‑β1/Smad pathway

Jiang, Honghao; Zhou, Xiaoyong

doi:10.3892/etm.2022.11603

Cited by 11 publications

(5 citation statements)

References 59 publications

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“…Its pharmacology may be related to the inhibition of hypertrophic scar formation by Suppressor of Mothers against Decapentaplegic (SMAD) protein family. Some scholars have shown that the main pharmacological effects of asiaticoside are anti-proliferation of tumor cells, induction of tumor cell apoptosis, anti-inflammation, anti-Alzheimer's disease, anti-depression and blood glucose control [12] . However, it has also been found to have a certain effect on skin repair in clinical practice.…”

Section: Resultsmentioning

confidence: 99%

Efficacy and Safety of Tranexamic Acid Combined with Hydroquinone Cream in the Treatment of Chloasma

Wu¹,

Wu²,

Ma³

et al. 2023

IJPS

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To study the efficacy and safety of tranexamic acid and hydroquinone cream with water light needle in the treatment of chloasma, and to provide clinical reference for the treatment of Chloasma is the main objective. A total of 230 patients with chloasma admitted to Fuyang Maternal and Child Health Hospital of Hangzhou from March 2019 to August 2022 were selected and divided into study group (n=115) and control group (n=115) according to the odd and even number of treatment. The study group received tranexamic acid injection with water-light needle and hydroquinone cream. In the control group, tranexamic acid was injected with water light needle and asiaticoside ointment was applied. After the treatment, the effective rate, melasma area and severity index, dermatology life quality index, recurrence rate and incidence of adverse drug reactions were compared between the two groups. After the treatment, the total effective rate of the study group was 94.78 %, which was significantly higher than 80.87 % of the control group (p<0.05). The melasma area and severity index and dermatology life quality index scores of the study group were lower than those of the control group (p<0.05), and the recurrence rate and adverse drug reaction rate of the study group were lower than those of the control group (p<0.05). Tranexamic acid and hydroquinone cream with water light needle in the treatment of melasma has obvious curative effect, high safety, low recurrence rate and high patient satisfaction, significantly enhance the quality of life and it is worthy of drug promotion.

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Section: Resultsmentioning

confidence: 99%

Efficacy and Safety of Tranexamic Acid Combined with Hydroquinone Cream in the Treatment of Chloasma

Wu¹,

Wu²,

Ma³

et al. 2023

IJPS

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“…The HaCaT human keratinocyte cell line was used to preliminarily evaluate by means of MTT assay the cytotoxicity of alcoholic extracts from L. austroapennina organs, using a broad range of dose levels (from 1 μg/mL to 100 μg/mL), at different exposure times (3, 6, 12 and 24 h). Human keratinocytes are a valid, in vitro, model for studying the toxicity profile of botanical products, as well as the inflammatory response, the healing properties and also for assuring dermoprotection against ROS-induced stress [57][58][59][60]. Data obtained, analyzed as the mean of three replicates, were organized into data matrix (5 organs × 5 concentrations × 4 treatment times) and processed by cluster analysis to explore the dissimilarity degree between plant organs, tested concentrations and treatment times.…”

Section: Cytotoxic Screening Of Alcoholic Extract From Lavandula Aust...mentioning

confidence: 99%

Lavandula austroapennina (Lamiaceae): Getting Insights into Bioactive Polyphenols of a Rare Italian Endemic Vascular Plant

Gravina

Formato

Piccolella

et al. 2023

IJMS

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Lavandula austroapennina N.G. Passal., Tundis and Upon has recently been described as a new species endemic to the southern Apennines (Italy). Locally, this species has a long ethnobotanical tradition of use for curative and decoration purposes and has been the protagonist of a flourishing essential oil production chain. Currently, while this tradition has long since ended, attention to the species is necessary, with a view to enhancing marginal and rural areas, as a recovery of a precious resource to (i) get insights into its (poly)phenolic fraction and (ii) address new and innovative uses of all its organs in various application fields (e.g., cosmeceutical sector). Therefore, after field sampling and dissection of its organs (i.e., corolla, calyx, leaf, stem and root), the latter, previously deterpenated and defatted, were subjected to accelerated ultrasound extraction and the related alcoholic extracts were obtained. Chemical composition, explored by UHPLC-QqTOF-MS/MS, and the following multivariate data analysis showed that the hydroxycinnamoyl derivatives are abundant in the leaf, stem and root, while flavonoids are more present in corolla and calyx. In particular, coumaroyl flavonoids with glyconic portion containing also hexuronyl moieties differentiated corolla organ, while yunnaneic acid D isomers and esculin distinguished root. When antiradical and reducing properties were evaluated (by means of ABTS, DPPH and PFRAP tests), a similar clustering of organs was achieved and the marked antioxidant efficacy of leaf, stem and root extracts was found. Thus, following cytotoxicity screening by MTT test on HaCaT keratinocytes, the protective effects of the organ extracts were assessed by wound closure observed after the scratch test. In addition, the extracts from corolla, leaf and stem were particularly active at low doses inducing rapid wound closure on HaCaT cells at a concentration of 1 μg/mL. The diversity in (poly)phenols of each organ and the promising bioactivity preliminarily assessed suggest further investigation to be carried out to fully recover and valorize this precious endemic vascular plant.

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“…Another in vivo study using a gel with C. asiatica standardized extract, containing madecassoside at 51% and asiaticoside at 38%, when applied after laser treatment, demonstrated facial acne scar improvement [172]. Asiaticoside also increased the activation of antioxidant levels at an early stage of the healing process through the regulation of the Smad pathway, via the transforming growth factor (TGF) β1 receptor, attenuating ROS generation and superoxide dismutase (SOD) reduction [173,174]. Through the modulation of the same via, asiaticoside reveals the ability to inhibit the growth of keloid hypertrophic scars [175].…”

Section: Asiatica and Pure Compoundsmentioning

confidence: 99%

How to Promote Skin Repair? In-Depth Look at Pharmaceutical and Cosmetic Strategies

et al. 2023

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Skin repair encompasses epidermal barrier repair and wound healing which involves multiple cellular and molecular stages. Therefore, many skin repair strategies have been proposed. In order to characterize the usage frequency of skin repair ingredients in cosmetics, medicines, and medical devices, commercialized in Portuguese pharmacies and parapharmacies, a comprehensive analysis of the products’ composition was performed. A total of 120 cosmetic products, collected from national pharmacies online platforms, 21 topical medicines, and 46 medical devices, collected from INFARMED database, were included in the study, revealing the top 10 most used skin repair ingredients in these categories. A critical review regarding the effectiveness of the top ingredients was performed and an in-depth analysis focused on the top three skin repair ingredients pursued. Results demonstrated that top three most used cosmetic ingredients were metal salts and oxides (78.3%), vitamin E and its derivatives (54.2%), and Centella asiatica (L.) Urb. extract and actives (35.8%). Regarding medicines, metal salts and oxides were also the most used (47.4%) followed by vitamin B5 and derivatives (23.8%), and vitamin A and derivatives (26.3%). Silicones and derivatives were the most common skin repair ingredients in medical devices (33%), followed by petrolatum and derivatives (22%) and alginate (15%). This work provides an overview of the most used skin repair ingredients, highlighting their different mechanisms of action, aiming to provide an up-to-date tool to support health professionals’ decisions.

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Asiaticoside delays senescence and attenuate generation of ROS in UV‑exposure cells through regulates TGF‑β1/Smad pathway

Cited by 11 publications

References 59 publications

Efficacy and Safety of Tranexamic Acid Combined with Hydroquinone Cream in the Treatment of Chloasma

Efficacy and Safety of Tranexamic Acid Combined with Hydroquinone Cream in the Treatment of Chloasma

Lavandula austroapennina (Lamiaceae): Getting Insights into Bioactive Polyphenols of a Rare Italian Endemic Vascular Plant

How to Promote Skin Repair? In-Depth Look at Pharmaceutical and Cosmetic Strategies

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