ASIC1 promotes differentiation of neuroblastoma by negatively regulating Notch signaling pathway

Liu, Mingli; Inoue, Kōichi; Leng, Tiandong; Zhou, An; Guo, Shanchun; Xiong, Zhi‐Gang

doi:10.18632/oncotarget.14164

Cited by 9 publications

(12 citation statements)

References 62 publications

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“…The formation of TMs shares many features with axon and neurite outgrowth, which is underlined by the phenotype observed after NOTCH1 knockdown. During neurodevelopment, NOTCH1 activation inhibits neurite sprouting 28 , 51 , whereas NOTCH1 inhibition has been shown to promote neurite extension 52 . NOTCH1 deficiency is only the third known molecular driver of TMs.…”

Section: Discussionmentioning

confidence: 99%

Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma

et al. 2021

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Both the perivascular niche (PVN) and the integration into multicellular networks by tumor microtubes (TMs) have been associated with progression and resistance to therapies in glioblastoma, but their specific contribution remained unknown. By long-term tracking of tumor cell fate and dynamics in the live mouse brain, differential therapeutic responses in both niches are determined. Both the PVN, a preferential location of long-term quiescent glioma cells, and network integration facilitate resistance against cytotoxic effects of radiotherapy and chemotherapy—independently of each other, but with additive effects. Perivascular glioblastoma cells are particularly able to actively repair damage to tumor regions. Population of the PVN and resistance in it depend on proficient NOTCH1 expression. In turn, NOTCH1 downregulation induces resistant multicellular networks by TM extension. Our findings identify NOTCH1 as a central switch between the PVN and network niche in glioma, and demonstrate robust cross-compensation when only one niche is targeted.

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Section: Discussionmentioning

confidence: 99%

Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma

et al. 2021

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“…Another finding from our dataset is the differential regulation of the acid-sensing ion channel subtype-1 (ASIC1), which we identified to have higher expression in TG versus DRG neurons. In addition to having been implicated in neurite outgrowth, neuronal differentiation, synaptic plasticity, learning, memory as well as neuronal injury ( Huang et al, 2013 ; Deval and Lingueglia, 2015 ; Liu et al, 2017 ), ASIC1 has a well-documented link to mechanoreception, nociception, and pain ( Deval and Lingueglia, 2015 ; Omerbasic et al, 2015 ). Previous studies also indicated that ASIC1 could be an analgesic target during pain states ( Mazzuca et al, 2007 ; Diochot et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

The Molecular Fingerprint of Dorsal Root and Trigeminal Ganglion Neurons

Lopes

Denk

McMahon

2017

Front. Mol. Neurosci.

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The dorsal root ganglia (DRG) and trigeminal ganglia (TG) are clusters of cell bodies of highly specialized sensory neurons which are responsible for relaying information about our environment to the central nervous system. Despite previous efforts to characterize sensory neurons at the molecular level, it is still unknown whether those present in DRG and TG have distinct expression profiles and therefore a unique molecular fingerprint. To address this question, we isolated lumbar DRG and TG neurons using fluorescence-activated cell sorting from Advillin-GFP transgenic mice and performed RNA sequencing. Our transcriptome analyses showed that, despite being overwhelmingly similar, a number of genes are differentially expressed in DRG and TG neurons. Importantly, we identified 24 genes which were uniquely expressed in either ganglia, including an arginine vasopressin receptor and several homeobox genes, giving each population a distinct molecular fingerprint. We compared our findings with published studies to reveal that many genes previously reported to be present in neurons are in fact likely to originate from other cell types in the ganglia. Additionally, our neuron-specific results aligned well with a dataset examining whole human TG and DRG. We propose that the data can both improve our understanding of primary afferent biology and help contribute to the development of drug treatments and gene therapies which seek targets with unique or restricted expression patterns.

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“…A shift in expression from a full-length Tnnt1 protein (in TSCs) to a shorter isoform in TGCs may have a similar role in migration and actin dynamics in TGCs [ 80 , 81 ]. Other genes with differentially expressed exons are known to be involved in several biological processes including cell growth, invasion, migration, apoptosis, and differentiation [ 82 , 83 ]. Cell type-specific expression of the identified exons may be important in maintaining stemness or inducing differentiation of trophoblast stem cells.…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic analysis reveals differential gene expression, alternative splicing, and novel exons during mouse trophoblast stem cell differentiation

et al. 2020

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Background: Differentiation of mouse trophoblast stem cells (TSCs) to trophoblast giant cells (TGCs) has been widely used as a model system to study placental development and function. While several differentially expressed genes, including regulators of TSC differentiation, have been identified, a comprehensive analysis of the global expression of genes and splice variants in the two cell types has not been reported. Results: Here, we report~7800 differentially expressed genes in TGCs compared to TSCs which include regulators of the cell cycle, apoptosis, cytoskeleton, cell mobility, embryo implantation, metabolism, and various signaling pathways. We show that several mitotic proteins, including Aurora A kinase, were downregulated in TGCs and that the activity of Aurora A kinase is required for the maintenance of TSCs. We also identify hitherto undiscovered, celltype specific alternative splicing events in 31 genes in the two cell types. Finally, we also report 19 novel exons in 12 genes which are expressed in both TSCs and TGCs. Conclusions: Overall, our results uncover several potential regulators of TSC differentiation and TGC function, thereby providing a valuable resource for developmental and molecular biologists interested in the study of stem cell differentiation and embryonic development.

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ASIC1 promotes differentiation of neuroblastoma by negatively regulating Notch signaling pathway

Cited by 9 publications

References 62 publications

Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma

Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma

The Molecular Fingerprint of Dorsal Root and Trigeminal Ganglion Neurons

Transcriptomic analysis reveals differential gene expression, alternative splicing, and novel exons during mouse trophoblast stem cell differentiation

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