ASO Author Reflections: Fertility-Sparing Treatment for Early-Stage Cervical Cancer 2 cm or Larger in Size: A Problem Still Open

Ronsini, Carlo; Solazzo, Maria Cristina; Bizzarri, Nicolò; Ambrosio, Domenico; Verde, Marco La; Torella, Marco; Carotenuto, Raffaela; Cobellis, Luigi; Colacurci, Nicola; Franciscis, Pasquale De

doi:10.1245/s10434-022-12556-3

Cited by 5 publications

(3 citation statements)

References 5 publications

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“…Cervical cancer (CCa) is one of the most common malignancies in women . As solid malignancies, the internal hypoxic environment makes them more prone to recurrence and metastasis and hinders the implementation of preoperative/postoperative radiotherapy and chemotherapy strategies. , Surgical resection is the main treatment for CCa, but it cannot preserve female fertility in most cases . In recent years, various advanced adjuvant therapies have emerged to ameliorate the problem of tumor hypoxia. − Among them, noninvasive sonodynamic therapy (SDT) achieves more powerful tissue penetration than photodynamic therapy (PDT) through photoacoustic action. − SDT utilizes mechanical waves with frequencies greater than 20 kHz that can safely penetrate tissue without significant attenuation .…”

Section: Introductionmentioning

confidence: 99%

“…2,3 Surgical resection is the main treatment for CCa, but it cannot preserve female fertility in most cases. 4 In recent years, various advanced adjuvant therapies have emerged to ameliorate the problem of tumor hypoxia. 5−7 Among them, noninvasive sonodynamic therapy (SDT) achieves more powerful tissue penetration than photodynamic therapy (PDT) through photoacoustic action.…”

Section: ■ Introductionmentioning

confidence: 99%

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ROS-Triggered Self-Assembled Nanoparticles Based on a Chemo-Sonodynamic Combinational Therapy Strategy for the Noninvasive Elimination of Hypoxic Tumors

Xie

et al. 2023

ACS Appl. Mater. Interfaces

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The hypopermeability and hypoxia in the tumor milieu are important factors that limit multiple treatments. Herein, the reactive oxygen species (ROS)-triggered self-assembled nanoparticles (RP-NPs) was constructed. The natural small molecule Rhein (Rh) was encapsulated into RP-NPs as a sonosensitizer highly accumulated at the tumor site. Then highly tissue-permeable ultrasound (US) irradiation induced apoptosis of tumor cells through the excitation of Rh and acoustic cavitation, which prompted the rapid production of large amounts of ROS in the hypoxic tumor microenvironment. In addition, the thioketal bond structures in the innovatively designed prodrug LA-GEM were triggered and broken by ROS to achieve rapid targeted release of the gemcitabine (GEM). Sonodynamic therapy (SDT) increased the tissue permeability of solid tumors and actively disrupted redox homeostasis via mitochondrial pathways to kill hypoxic tumor cells, and the triggered response mechanism to GEM synergistically amplified the effect of chemotherapy. The chemo-sonodynamic combinational treatment approach is highly effective and noninvasive, with promising applications for hypoxic tumor elimination, such as in cervical cancer (CCa) patients who want to maintain their reproductive function.

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Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

ROS-Triggered Self-Assembled Nanoparticles Based on a Chemo-Sonodynamic Combinational Therapy Strategy for the Noninvasive Elimination of Hypoxic Tumors

Xie

et al. 2023

ACS Appl. Mater. Interfaces

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“…Moreover, according to the Sedlis criteria, early cervical cancer patients with no lymph node (LN) metastasis but with LVSI require further LN dissection and postoperative radiotherapy to improve survival by eradicating micro-metastases ( 5 , 6 ). In addition, LVSI is an essential factor in the decision-making process for fertility-sparing treatments ( 7 , 8 ). For patients with LVSI who require fertility, a wide resection margin should be performed ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Whole-tumor histogram analysis of apparent diffusion coefficients for predicting lymphovascular space invasion in stage IB-IIA cervical cancer

et al. 2023

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ObjectivesTo investigate the value of apparent diffusion coefficient (ADC) histogram analysis based on whole tumor volume for the preoperative prediction of lymphovascular space invasion (LVSI) in patients with stage IB-IIA cervical cancer.MethodsFifty consecutive patients with stage IB-IIA cervical cancer were stratified into LVSI-positive (n = 24) and LVSI-negative (n = 26) groups according to the postoperative pathology. All patients underwent pelvic 3.0T diffusion-weighted imaging with b-values of 50 and 800 s/mm2 preoperatively. Whole-tumor ADC histogram analysis was performed. Differences in the clinical characteristics, conventional magnetic resonance imaging (MRI) features, and ADC histogram parameters between the two groups were analyzed. Receiver operating characteristic (ROC) analysis was used to evaluate the diagnostic performance of ADC histogram parameters in predicting LVSI.ResultsADCmax, ADCrange, ADC90, ADC95, and ADC99 were significantly lower in the LVSI-positive group than in the LVSI-negative group (all P-values < 0.05), whereas no significant differences were reported for the remaining ADC parameters, clinical characteristics, and conventional MRI features between the groups (all P-values > 0.05). For predicting LVSI in stage IB-IIA cervical cancer, a cutoff ADCmax of 1.75×10−3 mm2/s achieved the largest area under ROC curve (Az) of 0.750, followed by a cutoff ADCrange of 1.36×10−3 mm2/s and ADC99 of 1.75×10−3 mm2/s (Az = 0.748 and 0.729, respectively), and the cutoff ADC90 and ADC95 achieved an Az of <0.70.ConclusionWhole-tumor ADC histogram analysis has potential value for preoperative prediction of LVSI in patients with stage IB-IIA cervical cancer. ADCmax, ADCrange, and ADC99 are promising prediction parameters.

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Recent Advances in RNA Interference-Based Therapy for Hepatocellular Carcinoma: Emphasis on siRNA

Alzahrani,

Almutairy,

Althobaiti

et al. 2024

Cell Biochem Biophys

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ASO Author Reflections: Fertility-Sparing Treatment for Early-Stage Cervical Cancer 2 cm or Larger in Size: A Problem Still Open

Cited by 5 publications

References 5 publications

ROS-Triggered Self-Assembled Nanoparticles Based on a Chemo-Sonodynamic Combinational Therapy Strategy for the Noninvasive Elimination of Hypoxic Tumors

ROS-Triggered Self-Assembled Nanoparticles Based on a Chemo-Sonodynamic Combinational Therapy Strategy for the Noninvasive Elimination of Hypoxic Tumors

Whole-tumor histogram analysis of apparent diffusion coefficients for predicting lymphovascular space invasion in stage IB-IIA cervical cancer

Recent Advances in RNA Interference-Based Therapy for Hepatocellular Carcinoma: Emphasis on siRNA

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