Asociación de índices de composición corporal con resistencia a la insulina en adolescentes europeos: el estudio HELENA

Sesé, María A.; Moreno, Luís A.; Censi, Laura; Bresidenassel, Cristina; González‐Gross, Marcela; Sjöstróm, Michael; Μanios, Yannis; Molnár, Dénes; Dallongeville, Jean; Widhalm, Kurt; Gottrand, Frédéric; De-Henauw, Steffan; Marcos, Ascensión; Castillo, Manuel J.; Jiménez-Pavón, David

doi:10.20960/nh.257

Cited by 5 publications

(1 citation statement)

References 17 publications

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“…This will eventually lead to lower values of FFM/LBM in proportion to the total body weight. This effect on glucose homeostasis could be entirely or largely due to the association between adiposity and insulin resistance, previously described in children [ 143 ].…”

Section: Discussionmentioning

confidence: 89%

Fat-free/lean body mass in children with insulin resistance or metabolic syndrome: a systematic review and meta-analysis

et al. 2022

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Background Lean / Fat Free Body Mass (LBM) is metabolically involved in active processes such as resting energy expenditure, glucose uptake, and myokine secretion. Nonetheless, its association with insulin sensitivity / resistance / glucose tolerance and metabolic syndrome remains unclear in childhood. Methods The current investigation aimed to examine the differences in fat-free mass /lean body mass according to the presence of insulin sensitivity/insulin resistance/glucose tolerance/metabolic syndrome in children. A systematic search was carried out in Medline/PubMed, Embase, Scopus, Web of Science, and SciELO, covering the period from each database’s respective start to 21 June 2021. Two researchers evaluated 7111 studies according to the inclusion criteria: original human studies, written in English or Spanish, evaluating fat-free mass/lean body mass in children and adolescents including both with and without insulin sensitivity/insulin resistance /glucose tolerance and metabolic syndrome and reported the differences between them in terms of fat free mass/lean body mass. The results of the studies were combined with insulin sensitivity, insulin, resistance, glucose tolerance and metabolic syndrome. The standardized mean difference (SMD) in each study was calculated and combined using the random-effects model. Heterogeneity between studies was tested using the index of heterogeneity (I2), leave-one-out sensitivity analyses were performed, and publication bias was assessed using the Egger and Begg tests. Results Finally, 15 studies which compared groups defined according to different glucose homeostasis criteria or metabolic syndrome out of 103 eligible studies were included in this systematic review and 12 studies in the meta-analysis. Meta-analysis showed lower fat-free mass/lean body mass percentage in participants with insulin resistance/glucose tolerance/metabolic syndrome (SMD -0.47; 95% CI, − 0.62 to − 0.32) while in mass units (kg), higher values were found in the same group (SMD, 1.01; 95% CI, 0.43 to 1.60). Conclusions Our results identified lower values of fat-free mass/lean body mass (%) in children and adolescents with insulin resistance/glucose tolerance/metabolic syndrome and higher values of fat-free mass/lean body mass when these are expressed in kg. The evidence of the impact of lean mass on children’s glucose homeostasis or metabolic syndrome is limited, so future studies research should focus on explaining the effect of fat-free mass/lean body mass on different metabolic outcomes. Moreover, it may be interesting to evaluate the quality (muscle density) or functional (muscle strength) outcomes in addition to both absolute (kg) and relative (%) values in future studies. The systematic review was prospectively registered at PROSPERO (registration number CRD42019124734; available at: http://www.crd.york.ac.uk/prospero [accessed: 05 April 2019]).

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Section: Discussionmentioning

confidence: 89%

Fat-free/lean body mass in children with insulin resistance or metabolic syndrome: a systematic review and meta-analysis

et al. 2022

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Changes in the body composition of boys aged 11–18 years due to COVID-19 measures in the Czech Republic

et al. 2022

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Background The lockdown measures related to coronavirus disease 2019 (COVID) impacted the health of adolescents by reducing physical activity (PA). The physical changes in response to decreases in PA can be measured with full body composition analysis. The aim of this study was to evaluate the effects of long-term PA restrictions on body fat (BF), fat-free mass (FFM) and skeletal muscle mass (SMM) in adolescents. Methods A total of 1669 boys (before PA restriction (G1): 998; after PA restrictions ended (G2): 671; between the ages of 11 and 18 were included. The measured parameters were body mass (BM), visceral fat area (VFA), BF, FFM and SMM. The whole-body composition was evaluated using bioelectrical impedance analysis (BIA). Results Compared to G1, G2 exhibited an increase in BF between 1.2 and 5.1%. This difference was significant in boys aged 13 to 18 years (p < 0.05). VFA increased between 5.3 and 20.5 cm2; this increase was significant in boys aged 13 to 18 years (p < 0.05). SMM decreased between 2.6 and 3.8%, and this decrease was significant in all age groups (p < 0.05). Changes in body composition were not accompanied by any significant changes in BM. Conclusions COVID-19 restrictions reduced PA, resulting in a significant decrease in SMM. This decrease may impact boys’ ability to engage in sufficiently varied PA, which may lead to a further decline in PA and subsequent medical consequences in adulthood.

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Effect of excess adipose tissue in adolescent boys on the incidence of diabetes mellitus in adulthood: 31-year observation

Drapkina,

Rozanov,

Kontsevaya

et al. 2023

Profil. med.

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Asociación de índices de composición corporal con resistencia a la insulina en adolescentes europeos: el estudio HELENA

Cited by 5 publications

References 17 publications

Fat-free/lean body mass in children with insulin resistance or metabolic syndrome: a systematic review and meta-analysis

Fat-free/lean body mass in children with insulin resistance or metabolic syndrome: a systematic review and meta-analysis

Changes in the body composition of boys aged 11–18 years due to COVID-19 measures in the Czech Republic

Effect of excess adipose tissue in adolescent boys on the incidence of diabetes mellitus in adulthood: 31-year observation

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