Asociación de penfigoide y enfermedad neurológica: estudio de casos y controles

Casas-de-la-Asunción, E.; Ruano-Ruiz, Juan; Rodríguez-Martín, A.M.; García-Nieto, Antonio Vélez; Moreno‐Giménez, J.C.

doi:10.1016/j.ad.2014.04.013

Cited by 16 publications

(8 citation statements)

References 21 publications

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“…The association was also found in a population-based case–control study including 868 patients with BP and 3453 controls where PD was present in 26 cases (3%) and in 36 controls (1%),24 and similar findings were reported in a retrospective study from Olmsted County, MN 25. Along this line, a Spanish case–control study, including 56 patients with BP and 112 control subjects, reported a PD prevalence of 17.9% and 3.6% among BP patients and controls, respectively 27. Finally, a multi-center case–control study evaluating the risk factors for BP in elderly people found PD present in 14.3% of BP cases compared with only 5.8% control subjects 28.…”

Section: Skin Conditions In Pdsupporting

confidence: 75%

Skin disorders in Parkinson’s disease: potential biomarkers and risk factors

Ravn¹,

Thyssen²,

Egeberg³

2017

CCID

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Parkinson’s disease (PD) is one of the most common neurodegenerative disorders, characterized by a symptom triad comprising resting tremor, rigidity, and akinesia. In addition, non-motor symptoms of PD are well recognized and often precede the overt motor manifestations. Cutaneous manifestations as markers of PD have long been discussed, and cumulative evidence shows an increased prevalence of certain dermatological disorders in PD. Seborrheic dermatitis is considered to occur as a premotor feature of PD referable to dysregulation of the autonomic nervous system. Also, an increased risk of melanoma has been observed in PD. Light hair color is a known risk factor for melanoma, and interestingly the risk of PD is found to be significantly higher in individuals with light hair color and particularly with red hair. Furthermore, several studies have reported a high prevalence of PD in patients with bullous pemphigoid. Moreover, a 2-fold increase in risk of new-onset PD has been observed in patients with rosacea. Besides the association between PD and various dermatological disorders, the skin may be useful in the diagnosis of PD. Early PD pathology is found not only in the brain but also in extra-neuronal tissues. Thus, the protein α-synuclein, which is genetically associated with PD, is present not only in the CNS but also in the skin. Hence, higher values of α-synuclein have been observed in the skin of patients with PD. Furthermore, an increased risk of PD has been found in the Cys/Cys genotype, which is associated with red hair color. In this review, we summarize the current evidence of the association between PD and dermatological disorders, the cutaneous adverse effects of neurological medications, and describe the potential of skin protein expression and biomarkers in identification of risk and diagnosis of PD.

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Section: Skin Conditions In Pdsupporting

confidence: 75%

Skin disorders in Parkinson’s disease: potential biomarkers and risk factors

Ravn¹,

Thyssen²,

Egeberg³

2017

CCID

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“…Alzheimer's disease, frontotemporal lobar dementia and Parkinson's disease are the most common neurodegenerative disorders; all exhibit some sort of immunological association . Several studies have established an association between BP and dementia, but in most, dementia subtypes are not specified . In these studies, BP in patients with dementia had an adjusted risk ratio of between 2.2 and 10.1.…”

Section: Bp and Neurological Diseasesmentioning

confidence: 99%

“…BP also has a significant association with Parkinson's disease, and the risk ratio of BP in patients with Parkinson's disease has been reported as between 2.2 and 9.0 …”

Section: Bp and Neurological Diseasesmentioning

confidence: 99%

“…As expected, elderly BP patients suffer from cerebrovascular disorders. Several studies have demonstrated an association between BP and stroke, the adjusted risk varying between 1.8 and 6.0 . Previous studies have examined the association between BP and stroke, but with “stroke” being an unspecific term covering an array of cerebrovascular disorders.…”

Section: Bp and Neurological Diseasesmentioning

confidence: 99%

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Neurological and psychiatric associations in bullous pemphigoid—more than skin deep?

Försti

Huilaja

Schmidt

et al. 2017

Experimental Dermatology

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In elderly patients, bullous pemphigoid (BP) is associated with several comorbidities; the strongest association occurs between BP and neurological diseases. Different types of dementia, Parkinson's disease, cerebrovascular disorders and epilepsy all have a significant association with BP, but patients with multiple sclerosis have the highest risk of BP. An existing neurological disorder appears to increase the risk for subsequent BP, but an increased risk for developing some neurological diseases has also been reported following BP diagnosis. BP seems to be associated with several psychiatric diseases such as schizophrenia, uni-and bipolar disorder, schizotypal and delusional disorders, and personality disorders, but the risk ratios are usually lower than with neurological diseases. In addition to the skin, the BP autoantigens BP180 and BP230 are expressed in the central nervous system. This finding together with the strong epidemiological association between neurological disorders and BP has led to an assumption that neurodegeneration or neuroinflammation could lead to a crossreactive immunoresponse between neural and cutaneous antigens and the failure of self-tolerance. A subpopulation of patients with Alzheimer's disease or Parkinson's disease have circulating IgG autoantibodies against BP180, but currently their significance for the development of BP is unclear, because these antineural BP180 antibodies neither bind to the cutaneous basement membrane nor cause BP-like symptoms.Further studies analysing large and well-characterized populations of neurological and psychiatric patients are required to understand better the role of autoimmunization against neural BP autoantigens in the pathogenesis of BP. K E Y W O R D Sautoimmune disease, BP180, collagen XVII, dementia, multiple sclerosis

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“…This is usually explained by the cross-reaction of BPAG1/BPAG2 and the autoantibodies that are generated from the compromised brain-blood barrier (BBB) in neurologic disease [7]. Risk factors for the development of BP include the treatment of neuroleptics, diuretics, bipolar disorder [8,9], dementia, PD [10], and bed ridden [11]. …”

Section: Introductionmentioning

confidence: 99%

Increased Risk of Bullous Pemphigoid after First-Ever Stroke: A Population-Based Study

Shen

Lin

et al. 2017

Neurodegener Dis

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Background: We hypothesize that autoantibodies are induced after the blood-brain barrier is damaged by stroke and the risk of bullous pemphigoid (BP) is increased after stroke. We assess the risk of BP after first-ever stroke in a nationwide population-based cohort of first-ever stroke patients. Methods: We extracted data from the Longitudinal Health Insurance Database 2005 and identified patients with first-ever stroke as well as control patients matched for age, gender, and year of enrollment. The risk of BP in first-ever stroke patients in comparison with that in control patients was analyzed using Cox regression. Results: Of 12,607 patients with first-ever stroke, 38 (0.3%) patients developed BP in a median of 3.5 years. In the control patients, 8 persons (0.06%) had BP in a median of 3.7 years. The crude hazard ratio (HR) of BP in first-ever stroke patients was 4.83 (95% CI 2.25-10.34, p < 0.001) compared to the control group. The adjusted HR was 4.20 (95% CI 1.94-9.08, p < 0.001) after adjustments for age, gender, hypertension, diabetes, dementia, epilepsy, Parkinson disease, furosemide, and neuroleptics for stroke patients. Conclusions: The risk of BP is increased in first-ever stroke patients in a nationwide population-based cohort and this association is independent of well-known confounders of BP.

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Asociación de penfigoide y enfermedad neurológica: estudio de casos y controles

Cited by 16 publications

References 21 publications

Skin disorders in Parkinson’s disease: potential biomarkers and risk factors

Skin disorders in Parkinson’s disease: potential biomarkers and risk factors

Neurological and psychiatric associations in bullous pemphigoid—more than skin deep?

Increased Risk of Bullous Pemphigoid after First-Ever Stroke: A Population-Based Study

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Asociación de penfigoide y enfermedad neurológica: estudio de casos y controles

Cited by 16 publications

References 21 publications

Skin disorders in Parkinson&rsquo;s disease: potential biomarkers and risk factors

Skin disorders in Parkinson&rsquo;s disease: potential biomarkers and risk factors

Neurological and psychiatric associations in bullous pemphigoid—more than skin deep?

Increased Risk of Bullous Pemphigoid after First-Ever Stroke: A Population-Based Study

Contact Info

Product

Resources

About

Skin disorders in Parkinson’s disease: potential biomarkers and risk factors

Skin disorders in Parkinson’s disease: potential biomarkers and risk factors