Asociación entre los niveles de zinc intracelular y el estado nutricional de los niños infectados por el virus de la inmunodeficiencia humana (VIH) y los niños expuestos al virus no infectados

G, Erika María Gómez; C, María Elena Maldonado; L, Mauricio Rojas; J, Gladys Posada

doi:10.1016/j.rchipe.2015.04.021

Cited by 3 publications

(4 citation statements)

References 17 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The findings of this study also showed that HIV-infected children on ART had greater CD4 counts and were less likely of being underweight and wasted, which contributing to better health status and less hospitalization. Consistent with the previous studies, ART exerted a favorable effect on growth [ 2 , 6 , 32 ] and immune functions. [ 35 ]…”

Section: Discussionsupporting

confidence: 90%

“…[ 27 – 31 ] A previous study confirmed that growth retardation and the deterioration of nutritional status in children were associated with HIV infection. [ 32 ] The previous studies in South Africa and Tanzania demonstrated that HIV infection was associated with an increased burden of child underweight and wasting, [ 33 ] even among ART-treated children. [ 11 ] Infection with HIV causes immune impairment and further leads to malnutrition that could contribute to increased mortality in children.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Malnutrition is associated with HIV infection in children less than 5 years in Bobo-Dioulasso City, Burkina Faso

2017

View full text Add to dashboard Cite

Pediatric human immunodeficiency virus (HIV) infection and malnutrition are still 2 major health issues in sub-Saharan Africa including Burkina Faso where few studies have been conducted on child malnutrition and HIV infection. This study assessed the effects of antiretroviral therapy (ART) in HIV infection and also compared the prevalence of malnutrition in terms of an inadequate diet, underweight, stunting, and wasting among HIV-infected and uninfected children less than 5 years in Bobo-Dioulasso city, Burkina Faso.This was a case–control study matching for age and sex in 164 HIV-infected and 164 HIV-uninfected children. The sociodemographic characteristics of mothers and children, household food security, drinking water source, child feeding and care practices, and child anthropometric data such as body weight, height, and mid-upper arm circumference were collected.The prevalence of food insecurity and inadequate diet was 58% and 92% of children less than 5 years of age, respectively. The prevalence of underweight, stunting, and wasting was 77% versus 35%, 65% versus 61%, and 63% versus 26% in HIV-infected and uninfected children less than 5 years of age, respectively. Out of 164 HIV-infected children, 59% were on ART initiation during data collection and the median of CD4 cell counts was 1078 cells/μL. HIV-infected children on ART had greater CD4 cell counts (P = .04) and higher weight-for-age Z (P = .01) and weight-for-height Z scores (P = .03) than those without ART. HIV infection was a risk factor for those who had inadequate dietary intake [adjusted odds ratio (AOR) = 2.17, 95% confidence interval (CI) 1.17–3.62, P = .04]. In addition, HIV-infected children were more likely of being underweight (AOR = 10.24, 95% CI 4.34–24.17, P < 0.001) and wasting (AOR = 5.57, 95% CI 2.49–12.46, P < 0.001) than HIV-uninfected children less than 5 years of age.High prevalence of malnutrition was observed in HIV-infected children compared with HIV-uninfected children. Except for ART, nutritional assessment and support should be included in pediatric HIV management.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Malnutrition is associated with HIV infection in children less than 5 years in Bobo-Dioulasso City, Burkina Faso

2017

View full text Add to dashboard Cite

show abstract

“…This is like that reported age in Central and Western Africa (Chad, Cameroon, Mali, Ivory Coast, Togo, Benin) [ 17 ] but higher than that reported by studies in Nigeria and southern India [ 18 , 19 ]. A previous study confirmed that stunting and nutritional status deterioration in children were associated with HIV infection [ 20 ]. The late diagnosis of HIV infection, with resultant significant immunodeficiency, the duration of the disease, and inadequate nutrition are factors associated with chronic malnutrition [ 15 , 19 - 21 ].…”

Section: Discussionmentioning

confidence: 55%

Malnutrition among HIV infected children under 5 years of age at the Laquintinie hospital Douala, Cameroon

Penda¹,

Moukoko²,

Nolla³

et al. 2018

Pan Afr Med J

View full text Add to dashboard Cite

IntroductionThe aim of this study was to assess the prevalence of malnutrition among HIV infected children under five years of age followed up at the Laquintinie Hospital Douala (LHD).MethodsMedical records of children aged 13 days-59 months enrolled at initiation of antiretroviral treatment in the Day Care Unit/LHD, were reviewed for a period of 14 years (from 2002 to 2015). We used standard Z-scores, with cut-off point of <-2 SD to define low height-for-age (HAZ), low weight-for-height (WHZ) and low weight-for-age (WAZ). Factors associated with malnutrition were assessed according to World Health Organization (WHO) criteria.ResultsOverall, 217 medical records were included and 52.5% were records of boys. The median weight, height and age of the children was 9.5 kg (range: 2.5-20), 76 cm (range: 46- 117) and 22 months (range: 0.03-59), respectively. The overall prevalence of malnutrition among HIV-infected children was 68.7%; 63.6% were stunted (HAZ<-2), 37.8% were underweight (WAZ<-2) and 18.4 % were wasted (WHZ<-2). Severe and advanced immunological stages of HIV according to WHO were found in 42.4%, (39/92) and 17.4%, (16/92) of children respectively, and most of them (21.7%) were aged 12-36 months. The overall prevalence of anemia, oropharyngeal candidiasis and pulmonary tuberculosis were 34.6%, 12% and 8.8%, respectively. Oropharyngeal candidiasis was a risk factor independently associated with severe underweight and wasting (OR = 4.9, 95% CI: 1.8-13.5, p = 0.002) and (OR = 5.1, 95% CI: 1.5-17.1, p = 0.007).ConclusionHIV infection negatively affects the nutritional status of children under five years of age. Early detection of malnutrition is necessary and adequate nutrition should be integrated into the management of pediatric HIV.

show abstract

“…Asimismo, en países asiáticos la prevalencia de desnutrición global en población pediátrica con VIH oscila entre 17-63% (9,16) . Con respecto al diagnóstico de desnutrición crónica, similares resultados se reportaron para pacientes con VIH de 15 meses a 19 años (9,(17)(18)(19) . Otros estudios epidemiológicos documentaron mayor prevalencia de desnutrición crónica (2,16,20,21) observando el retraso del crecimiento lineal en niños mayores de 9, probablemente debido a la progresión de la enfermedad (16,21) .…”

Section: Discussionunclassified

Evolución del estado nutricional, parámetros inmunológicos y virológicos en niños con VIH de transmisión vertical bajo tratamiento antirretroviral

Oberto

Asis

Defagó

2021

Rev Fac Cien Med Univ Nac Cordoba

View full text Add to dashboard Cite

Introducción: la vigilancia del crecimiento de manera continua permite la identificación de alteraciones antropométricas y metabólicas como parte integral del tratamiento en VIH. Se propuso analizar la evolución del estado nutricional, con los parámetros inmunológicos y virológicos en niños infectados con VIH de transmisión vertical y su asociación con el tratamiento antirretroviral de gran actividad (TARGA). Material y Métodos: se incluyeron 56 niños de 0-12 años, asistentes al Hospital Materno Neonatal de Córdoba, Argentina entre 1998-2014. Se evaluó, por grupo etario (menor o mayor de 6 años) y TARGA administrado, el estado nutricional antropométrico y bioquímico, inmunológico, virológico y manifestaciones clínicas en tres controles médicos. Resultados: en el tercer control el análisis del estado nutricional antropométrico según el índice de masa corporal (IMC) diagnosticó 47 niños (83,93%) con un IMC normal y 6 (10,71%) sobrepeso/obesidad, sin diferencia estadísticamente significativa por grupo etario (p=0,10). Treinta y seis niños (64,29%) presentaron hipertrigliceridemia, siendo mayores las concentraciones al segundo (p=0,003) y tercer control (p=0,06) en los tratados con esquema II y III con inhibidores de proteasa (IP), a diferencia del esquema I sin IP. La normoglucemia prevaleció en 54 niños (96,43%) y la anemia en 29 (51,79%). Las manifestaciones clínicas disminuyeron en los sucesivos controles y en el último, 3 niños (5,36%) mayores de 6 años, tuvieron neumonía y uno (1,79%) inmunosupresión grave. Conclusiones: la hipertrigliceridemia fue el principal efecto adverso de la medicación que, sumados a la alta prevalencia de anemia, constituyen parámetros importantes para el tratamiento de manera interdisciplinaria.

show abstract

Asociación entre los niveles de zinc intracelular y el estado nutricional de los niños infectados por el virus de la inmunodeficiencia humana (VIH) y los niños expuestos al virus no infectados

Abstract: The deterioration of nutritional status and growth retardation in children were associated with HIV, but not with the levels of intracellular zinc. The dietary intake of this nutrient was not associated with levels of zinc in monocytes or CD4 + and CD4- lymphocytes.

Cited by 3 publications

References 17 publications

Malnutrition is associated with HIV infection in children less than 5 years in Bobo-Dioulasso City, Burkina Faso

Malnutrition is associated with HIV infection in children less than 5 years in Bobo-Dioulasso City, Burkina Faso

Malnutrition among HIV infected children under 5 years of age at the Laquintinie hospital Douala, Cameroon

Evolución del estado nutricional, parámetros inmunológicos y virológicos en niños con VIH de transmisión vertical bajo tratamiento antirretroviral

Contact Info

Product

Resources

About