Asociación entre neuroimagen y secuelas neurológicas en pacientes con infección congénita por citomegalovirus

Castellanos, María Escobar; Navazo, Sara de la Mata; Bermejo, Marta; Morin, M; Ruiz, Yolanda; Lozano, J. Saavedra; Herrero, M.C. Miranda; Valderrama, Estíbaliz Barredo; Castro, P. Castro de; Vázquez-López, M

doi:10.1016/j.nrl.2018.11.003

Cited by 2 publications

(1 citation statement)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While an ultrasound (US) is the method of choice for fetal and neonatal imaging, magnetic resonance imaging (MRI) has an established added value in the detection of fetal and neonatal brain anomalies, including white matter signal abnormalities, cortical defects (e.g., polymicrogyria), and cerebellar hypoplasia/dysplasia [3,7]. Abnormal neuroimaging results may predict an increased risk of adverse neurodevelopmental sequalae with a high negative predictive value for fetal MRI findings [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Single Nucleotide Polymorphisms of Interleukins and Toll-like Receptors and Neuroimaging Results in Newborns with Congenital HCMV Infection

Czech‐Kowalska

Jedlińska-Pijanowska

Pleskaczyńska

et al. 2021

Viruses

View full text Add to dashboard Cite

Congenital cytomegalovirus infection (cCMV) is the most common intrauterine infection with central nervous system (CNS) involvement. There is limited data on the associations between Single Nucleotide Polymorphisms (SNPs) in genes involving the first-line defense mechanism and the risk of CNS damage during cCMV. We investigated the associations between neuroimaging findings and SNPs in genes encoding the following cytokines and cytokine receptors in 92 infants with cCMV: interleukins (IL1B rs16944, IL12B rs3212227, IL28B rs12979860), C-C motif chemokine ligand 2 (CCL2 rs1024611), dendritic cell-specific intercellular adhesion grabbing non-integrin (DC-SIGN rs735240), Toll-like receptors (TLR2 rs5743708, TLR4 rs4986791, TLR9 rs352140). The SNP of IL1B rs16944 (G/A) was associated with a reduced risk of ventriculomegaly on MRI (OR = 0.46, 95% CI, 0.22–0.95; p = 0.03) and cUS (OR = 0.38, 95% CI, 0.0–0.93; p = 0.034). Infants carrying heterozygous (T/C) genotype at IL28B rs12979860 had an increased risk of cystic lesions on cUS (OR = 3.31, 95% CI, 1.37–8.01; p = 0.0064) and MRI (OR = 4.97, 95% CI, 1.84–13.43; p = 0.001), and an increased risk of ventriculomegaly on MRI (OR = 2.46, 95% CI, 1.03–5.90; p = 0.04). No other associations between genotyped SNPs and neuroimaging results were found. This is the first study demonstrating new associations between SNPs of IL1B and IL28B and abnormal neuroimaging in infants with cCMV.

show abstract