Asociación entre obesidad y cáncer de ovario

Valladares, Macarena; Corsini, Gino; Romero, Carmen

doi:10.4067/s0034-98872014000500007

Cited by 9 publications

(4 citation statements)

References 42 publications

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“…Overweight and obese patients had higher ascites levels compared with healthy BMI cancer patients. Therefore, high leptin levels, and perhaps high levels of other cytokines (e.g., IL-6), in obese patients could contribute to the maintenance and survival of the dormant cancer cells that remain after debulking surgery (e.g., floating cells in the ascites or abdominal cavity), facilitating their settlement in new secondary locations (e.g., adipose tissues or mesothelium at the peritoneum) and the reappearance of recurrent disease [ 8 , 39 , 40 ]. In this sense, and despite the fact that we did not utilize serum or/and ascites samples from our entire cohort to measure the leptin levels, we were able to analyze five matched serum/ascites cases with adverse outcomes.…”

Section: Discussionmentioning

confidence: 99%

Leptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells: an explanation for poor outcomes in obese women

et al. 2015

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The evidence linking obesity with ovarian cancer remains controversial. Leptin is expressed at higher levels in obese women and stimulates cell migration in other epithelial cancers. Here, we explored the clinical impact of overweight/obesity on patient prognosis and leptin's effects on the metastatic potential of ovarian cancer cells. We assessed clinical outcomes in 70 ovarian cancer patients (33 healthy weight and 37 overweight) that were validated with an external cohort from The Cancer Genome Atlas (TCGA) database. Progression-free and overall survival rates were significantly decreased in overweight patients. Similarly, a worse overall survival rate was found in TCGA patients expressing higher leptin/OB-Rb levels. We explored serum and ascites leptin levels and OB-Rb expression in our cohort. Serum and ascites leptin levels were higher in overweight patients experiencing worse survival. OB-Rb was more highly expressed in ascites and metastases than in primary tumors. Leptin exposure increased cancer cell migration/invasion through leptin-mediated activation of JAK/STAT3, PI3/AKT and RhoA/ROCK and promoted new lamellipodial, stress-fiber and focal adhesion formation. Leptin also contributed to the maintenance of stemness and the mesenchymal phenotype in ovarian cancer cells. Our findings demonstrate that leptin stimulated ovarian cancer cell migration and invasion, offering a potential explanation for the poor prognosis among obese women.

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Section: Discussionmentioning

confidence: 99%

Leptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells: an explanation for poor outcomes in obese women

et al. 2015

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“…4 After years of study, researchers have discovered several risk factors that might increase a woman's chance of developing ovarian cancer, among them, obesity is the most important risk factor. 5 Obese women have a higher risk of developing ovarian cancer, and obesity also affects the overall survival of a woman with ovarian cancer. 6,7 With the introduction of high-fructose corn syrup into the food processing industry in the 1970s, the per capita consumption of fructose increased year by year.…”

Section: Introductionmentioning

confidence: 99%

<p>GLUT5 increases fructose utilization in ovarian cancer</p>

Jin¹,

Gong²,

Shang³

2019

OTT

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Background: Fructose is one of the most common dietary carbohydrates in the whole world, and recent studies have found that fructose consumption is closely related to the oncogenesis and development of tumors, however, very few studies have focused on the fructose in ovarian cancer. GLUT5 (Glucose transporter type 5), as a specific fructose transporter in mammalian cells, has also been found highly expressed in many cancers. Methods: In this study, we investigated the abilities of proliferation, colony formation, and migration of ovarian cancer cells in fructose medium, and then silenced GLUT5 in ovarian cancer cells to explore the role GLUT5 in fructose metabolism in ovarian cancer. Results: The results showed that the ovarian cancer cells had similar abilities of proliferation and migration in fructose medium and glucose medium, but silencing GLUT5 could significantly inhibit these abilities in fructose medium. Meanwhile, we found that GLUT5 was higher expressed in ovarian cancer tissues, and its expression correlated significantly with tumor malignancy and poor survival of ovarian cancer patients. Furthermore, the results of animal experiments also demonstrated that intake too much fructose could prominently increase tumor volume, and silencing GLUT5 could significantly inhibit tumor proliferation. Conclusion: In conclusion, we demonstrate that ovarian cancer cells could utilize fructose for their growth, and restricting the fructose intake or targeting GLUT5 may be efficacious strategies for ovarian cancer therapy.

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“…Uma causa considerada importante é a "ovulação incessante", com o epitélio do ovário sofrendo alterações, e assim, há uma constante renovação do tecido epitelial, estimulação do ovário, altas concentrações de gonadotrofinas e estrogênio que condicionaria as células para a malignidade. O câncer de ovário é a enfermidade ginecológica de maior letalidade, sendo a quarta causa das mortes por câncer na população ocidental (VALLADARES; CORSINI; ROMERO, 2014).…”

Section: Câncer De Ováriounclassified

Usos não contraceptivos dos fármacos anticoncepcionais hormonais

Oliveira

2022

cmbio

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Introdução: Os anticoncepcionais hormonais são fármacos constituídos por hormônios, geralmente combinados, estrogênio e progestogênio, ou apenas progestogênio. Devido às propriedades características desses hormônios, são também responsáveis por diversos efeitos colaterais, o que tem levado a uma evolução contínua das formulações e tem-se observado vários benefícios não contraceptivos à saúde da mulher. Objetivo: O objetivo dessa revisão foi analisar os usos não contraceptivos dos anticoncepcionais hormonais, evidenciando sua eficácia e segurança. Metodologia: A pesquisa foi realizada em bases de dados eletrônicos e portais de busca, priorizando materiais publicados na faixa anual de 2008 a 2018, sendo encontrados 332 e utilizados 148 materiais de estudo. Resultados: Esses fármacos tem sido uma alternativa eficaz de tratamento da síndrome do ovário policístico, uma vez que reduzem os androgênios circulantes e induzem a melhora dos sintomas como acne, irregularidade menstrual e dismenorreia. Estão associados ao tratamento da endometriose e à menor incidência de câncer de ovário, exercendo um efeito protetor durante anos, até mesmo após a interrupção. Conclusão: Assim, os anticoncepcionais hormonais têm representado uma nova proposta terapêutica simples, segura e eficaz, e seus benefícios ultrapassam os riscos associados, proporcionando uma terapia adequada e individualizada para cada mulher. Non-contraceptive uses of hormonal contraceptive drugs: a review

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Asociación entre obesidad y cáncer de ovario

Cited by 9 publications

References 42 publications

Leptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells: an explanation for poor outcomes in obese women

Leptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells: an explanation for poor outcomes in obese women

<p>GLUT5 increases fructose utilization in ovarian cancer</p>

Usos não contraceptivos dos fármacos anticoncepcionais hormonais

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