2013
DOI: 10.4103/0970-1591.109982
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Asp299Gly and Thr399Ile polymorphism of TLR-4 gene in patients with prostate cancer from North India

Abstract: Background:The etiological factors associated with prostate cancer (CaP) have not been completely understood as yet. Genetic predisposition and inflammation is fast emerging as risk factors for CaP is a key player in the innate immune response and plays role in immune- surveillance and inflammation. The present study was conducted to evaluate TLR-4 gene polymorphism in patients with CaP.Material and Methods:DNA was isolated from blood samples of 198 patients with CaP, 200 cases of Benign Prostatic Hyperplasia … Show more

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Cited by 18 publications
(14 citation statements)
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“…Controversial results have been shown by Davoodi and Seow, suggesting that both TLR4 Asp299Gly and Thr399Ile alleles are not associated with CRC risk [ 34 ]. Other studies showed that the detection TLR4 Asp299Gly polymorphism had a 4-fold higher risk for development of prostate cancer, among a North Indian population [ 35 ]. However, the results from a meta-analysis suggest that the TLR4 Asp299Gly polymorphism had a protective effect in prostate cancer; whereas, both TLR4 Asp299Gly and Thr399Ile polymorphisms were associated with an elevated gastrointestinal cancer risk [ 36 37 ].…”
Section: Discussionmentioning
confidence: 99%
“…Controversial results have been shown by Davoodi and Seow, suggesting that both TLR4 Asp299Gly and Thr399Ile alleles are not associated with CRC risk [ 34 ]. Other studies showed that the detection TLR4 Asp299Gly polymorphism had a 4-fold higher risk for development of prostate cancer, among a North Indian population [ 35 ]. However, the results from a meta-analysis suggest that the TLR4 Asp299Gly polymorphism had a protective effect in prostate cancer; whereas, both TLR4 Asp299Gly and Thr399Ile polymorphisms were associated with an elevated gastrointestinal cancer risk [ 36 37 ].…”
Section: Discussionmentioning
confidence: 99%
“…Polymorphisms of rs4986790 and rs4986791 in exon 3, leading respectively to the substitution of Asp299Gly and Thr399Ile amino acid and downregulating the expression of several genes in the TLR4 TRAM/TRIF signaling pathway [ 34 ], was associated with endotoxin hyporesponsiveness [ 35 ], gram-negative septic shock [ 36 ] and atherogenesis [ 37 ]. However, analyses focusing on them did not reach a consensus on cancer risk and some proved they had a nonnegligible impact on breast cancer [ 11 , 13 ] and digestive cancer [ 23 , 26 ], while the others believed that no evident could support significant association with gastric cancer [ 38 , 39 ], bladder cancer [ 40 ], prostate cancer [ 20 ], leukemia [ 41 ]. To minimized the effects of sample size, a large amount of publications on variant cancers were collected in this study and the consequence reflected there was a significant association between rs4986791 polymorphism and the decrease of cancer risk while polymorphism of rs4986790 was found irrelevant to cancer risk.…”
Section: Discussionmentioning
confidence: 99%
“…Other studies have also presented the correlation between TLR-2 polymorphism and papillary thyroid cancer in the Korean population 30. Recently, several studies have demonstrated that the presence of the TLR-4 Asp299Gly polymorphism is associated with a higher frequency of prostate cancer in the North Indian population 31. It has also been shown that TLRs are implicated in the progression of polyps to tumors and that increased metastatic potential of colorectal cancers was correlated with reduced TLR expression 31,32.…”
Section: Introductionmentioning
confidence: 99%
“…Recently, several studies have demonstrated that the presence of the TLR-4 Asp299Gly polymorphism is associated with a higher frequency of prostate cancer in the North Indian population 31. It has also been shown that TLRs are implicated in the progression of polyps to tumors and that increased metastatic potential of colorectal cancers was correlated with reduced TLR expression 31,32. TLR-4 polymorphism rs11536898 has also been shown to be connected with colon cancer 26.…”
Section: Introductionmentioning
confidence: 99%