Aspalathin: a rare dietary dihydrochalcone from Aspalathus linearis (rooibos tea)

Chaudhary, Sushil Kumar; Sandasi, Maxleene; Makolo, Felix L.; Heerden, Fanie R. van; Viljoen, Alvaro

doi:10.1007/s11101-021-09741-9

Cited by 7 publications

(3 citation statements)

References 102 publications

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“…The antimutagenic assay revealed that unfermented rooibos and honey bush tea extracts had a strong antimutagenic effect against both metabolically activated carcinogens, antimutagenic activity against 2-acetylaminofluorene (2-AAF) and (aflatoxin) AFB1 (Marnewick et al, 2000;Chaudhary et al, 2021). Carabajal et al (2017), also discovered that antimutagenic activity of the freeze-dried plant infusions tested against a direct-acting mutagen (4-NPD), with at least three herbal mixtures resulting to a positive response.…”

Section: Anti-mutagenic/anti-carcinogenic Activitiesmentioning

confidence: 99%

Eco-physiological response of secondary metabolites of teas: Review of quality attributes of herbal tea

Ramphinwa

Mchau²,

Mashau³

et al. 2023

Front. Sustain. Food Syst.

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Herbal tea is a rich source of secondary metabolites which are reputed to have medicinal and nutritional efficacy. These secondary metabolites are influenced by the abiotic and biotic stresses that improve the production of herbal teas in terms of biomass production, accumulation and partitioning of assimilates of compounds. In this study, various examples of herbal teas have been shown to respond differently to secondary metabolites affected by environmental factors. Thus, the meta-analysis of this study confirms that different herbal teas' response to environmental factors depends on the type of species, cultivar, and the degree of shade that the plant is exposed. It is also evident that the metabolic processes are also known to optimize the production of secondary metabolites which can thus be achieved by manipulating agronomic practices on herbal teas. The different phenolic compound in herbal teas possesses the antioxidant, antimicrobial, antiatherosclerosis, anti-inflammatory, antimutagenic, antitumor, antidiabetic and antiviral activities that are important in managing chronic diseases associated with lifestyle. It can be precluded that more studies should be conducted to establish interactive responses of biotic and abiotic environmental factors on quality attributes of herbal teas.

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Section: Anti-mutagenic/anti-carcinogenic Activitiesmentioning

confidence: 99%

Eco-physiological response of secondary metabolites of teas: Review of quality attributes of herbal tea

Ramphinwa

Mchau²,

Mashau³

et al. 2023

Front. Sustain. Food Syst.

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“…In recent years, research on medicinal plants as potential chemotherapeutic agents has increased globally because of their actions that prevent cancer initiation and proliferation with limited toxicity, as well as their anti-multidrug reversal ability [86,87]. There are very few scientific studies on Merremia species as anticancer agents, but their traditional use in treating breast cancer may have prompted investigations on their potential anticancer and antiproliferative properties as discussed below.…”

Section: Cancer Cell Cytotoxicitymentioning

confidence: 99%

Research Progression of the Genus Merremia: A Comprehensive Review on the Nutritional Value, Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicity

Olatunji

Adetunji

Olisah

et al. 2021

Plants

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The genus Merremia Dennst. ex Endl. (Convolvulaceae) is a rich source of structurally diverse phytochemicals with therapeutic relevance. This review presents the first comprehensive, up-to-date information and research progression on the nutritional value, ethnomedicinal uses, phytochemistry, pharmacological activities, and toxicity of the genus Merremia. Using the key search term “Merremia”, relevant documents and information were retrieved from electronic databases. Relevant documents were uploaded in RStudio with installed bibliometric software packages and used for data retrieval, tabulation, and network visualization. Bibliometric analysis revealed that ca. 55% of the studies related to Merremia were published in the last decade, which can be grouped into four thematic areas: (i) drug formulation, (ii) taxonomy, (iii) chemical analysis, and (iv) treatment of diseases. Ethnomedicinal uses, phytochemistry, and biological activities studies showed that species in the genus are promising medicinal plants with various pharmaceutical potentials. However, clinical studies to validate the efficacy of the reported bioactivities and the mechanisms underlying the various activities are lacking and should constitute a future research focus. Additionally, reports on the nutritional and antinutritional constituents of Merremia species revealed that the species meet high nutritional quality criteria for animals and are therefore suitable for inclusion in livestock diets. The few available investigations on toxicity indicated that most Merremia species are safe for human and animal use but not with prolonged chronic administration.

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“…ASP derivatives are known to have a dihydrochalcone skeleton and are connected with a C -glycosidic linkage [ 11 , 24 ]. Several studies have demonstrated the potent antioxidant properties of ASP [ 24 , 25 , 26 ] with percutaneous permeation studies revealing some degree of absorption through the skin [ 27 ] which supports its use in cosmeceutical preparations. However, evidence on the role of ASP in UVB-induced skin damage is still lacking.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Linearthin and Other Chalcone Derivatives from Aspalathus linearis (Rooibos) against UVB Induced Oxidative Stress and Toxicity in Human Skin Cells

Akinfenwa

Abdul

Marnewick

et al. 2021

Plants

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Skin cells suffer continuous damage from chronic exposure to ultraviolet light (UV) that may result in UV-induced oxidative stress and skin thinning. This has necessitated the formulation of cosmeceutical products rich in natural antioxidants and free radical scavengers. Aspalathus linearis (rooibos) is an endemic South African fynbos plant growing naturally in the Western Cape region. The plant is rich in phenolics and other bioactives with a wide spectrum of health benefits. The chemical study of an acetonic extract of green A. linearis afforded a novel compound named linearthin (1) and two known dihydrochalcones, aspalathin (2) and nothofagin (3). The chemical structure of the novel compound was elucidated based on spectroscopic data analysis. The bio-evaluation of the isolated chalcones in vitro for protection against UVB-induced oxidative stress were systematically assessed by examining cell viability, metabolic activity, apoptosis, and cytotoxicity using HaCaT and SK-MEL-1 skin cells models. It was observed that pre-treatment with tested samples for 4- and 24 h at low concentrations were sufficient to protect skin cells from UVB-induced damage in vitro as evidenced by higher cell viability and improved metabolic activity in both keratinocytes (HaCaT) and melanocytes (SK-MEL-1). The results further show that the pre-treatment regimen employed by this study involved some degree of cellular adaptation as evidenced by higher levels of reduced glutathione with a concomitant decrease in lipid peroxidation and lowered caspase 3 activity. Furthermore, compound 1 was most cytoprotective against UVB irradiation of HaCaT cell line (over 24 h) with an IC50 of 282 µg/mL and SK-MEL-1 cell line with IC50 values of 248.3 and 142.6 µg/mL over 4 and 24 h, respectively. On the other hand, HaCaT cells exposed to 2 over 4 h before UVB irradiation showed the highest degree of cytoprotection with an IC50 of 398.9 µg/mL among the four studied samples. These results show that linearthin (1) and the two glycoside dihydrochalcone of A. linearis have the potential to be further developed as antioxidant cosmeceutical ingredients that may protect skin against UVB-induced damage.

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Aspalathin: a rare dietary dihydrochalcone from Aspalathus linearis (rooibos tea)

Cited by 7 publications

References 102 publications

Eco-physiological response of secondary metabolites of teas: Review of quality attributes of herbal tea

Eco-physiological response of secondary metabolites of teas: Review of quality attributes of herbal tea

Research Progression of the Genus Merremia: A Comprehensive Review on the Nutritional Value, Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicity

Protective Effects of Linearthin and Other Chalcone Derivatives from Aspalathus linearis (Rooibos) against UVB Induced Oxidative Stress and Toxicity in Human Skin Cells

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