Aspalathin and Nothofagin from Rooibos (Aspalathus linearis) Inhibits High Glucose-Induced Inflammation In Vitro and In Vivo

Ku, Sae‐Kwang; Kwak, Soyoung; Kim, Yaesol; Bae, Jong‐Sup

doi:10.1007/s10753-014-0049-1

Cited by 66 publications

(28 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Demonstration of antidiabetic properties for aspalathin (Kawano et al, 2009;Muller et al, 2012;Son et al, 2013;Mazibuko et al, 2015), the major flavonoid and novel dihydrochalcone of green rooibos extracts with anti-diabetic activity (Kamakura et al, 2015;Muller et al, 2012), indicates its relevance as a critical quality parameter. Other compounds of importance in the same context are nothofagin, the 3-deoxy analogue of aspalathin, and the flavone derivatives of aspalathin, iso-orientin and orientin, by virtue of their relevant prominence in these extracts and their bioactivity (Sezik et al, 2005;Alonso-Castro et al, 2012;Annapurna et al, 2013;Mazibuko, 2014;Ku et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Production of dihydrochalcone-rich green rooibos (Aspalathus linearis) extract taking into account seasonal and batch-to-batch variation in phenolic composition of plant material

Beer

Miller

2017

South African Journal of Botany

View full text Add to dashboard Cite

a b s t r a c t a r t i c l e i n f o Available online xxxx Edited by: J. van StadenRandomly selected rooibos plants from three plantations were harvested (a few branches per plant) at intervals from early summer to late spring. The aspalathin and nothofagin content of the plant material was highest at the first harvest date (3.76% and 0.54%, respectively) in summer whereafter their content decreased gradually to the lowest levels in winter and increased to 3.31% and 0.36%, respectively in mid-spring. Commercial green rooibos production batches (n = 47), produced over a period of 49 days (end of January until mid-March) from plant material harvested from one plantation were analysed to provide further insight into expected batch-to-batch variation in aspalathin, nothofagin, orientin and iso-orientin content. The aspalathin content of green rooibos varied between 2.50% and 4.49%, even though the plant material was harvested from the same plantation. The other compounds were present in the plant material in much lower quantities (b0.5%). The iso-orientin and orientin contents of the green rooibos samples did not vary substantially. The variation observed in the plant material was subsequently also observed in the freeze-dried hot water extracts prepared from the commercial green rooibos production batches, with the theoretical dried extract yield varying between 15.07% and 22.89%. The aspalathin content and total polyphenol content of the dried extract varied between 8.11% and 12.33% and between 29.7 and 43.5 g gallic acid equivalents/100 g, respectively. The mean content values for the other compounds were less than 1.2%. Combined these major dihydrochalcones and flavones comprised between 10.22% and 14.88% of the freeze-dried extract. Aspalathin contributed between 13.1% and 22.8% of the total antioxidant capacity (2873-4286 μmol Trolox equivalents/g) of the dried extract as determined by the DPPH radical scavenging assay.

show abstract

Section: Introductionmentioning

confidence: 99%

Production of dihydrochalcone-rich green rooibos (Aspalathus linearis) extract taking into account seasonal and batch-to-batch variation in phenolic composition of plant material

Beer

Miller

2017

South African Journal of Botany

View full text Add to dashboard Cite

show abstract

“…Plants derived polyphenols such as quercetagetin, fisetin, and quercetin, which belong to the flavonoid family, have been shown to be effective inhibitors of mammalian alpha-amylase with IC50s in the order of µM [1]. Aspalathin (Asp) is the major active dihydrochalcones found in green rooibos, which have been reported many interesting biological properties [12]. These include its antiinflammatory, antioxidant, antidiabetic, antihyperuricemic [13,14].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Aspalathin on Levels of Sugar and Lipids in Streptozotocin-Induced Diabetic and Normal Rats

Najafian

2016

Zahedan J Res Med Sci

View full text Add to dashboard Cite

show abstract

“…This effect was important since experimental and clinical studies support the notion that drug compounds that enhance intracellular antioxidant properties can further exhibit a wide range of beneficial effects against the development of metabolic syndrome [29]. In addition to its robust antioxidant activity [28,[30][31][32][33][34], aspalathin can ameliorate inflammation [35][36][37][38][39], protect cardiac cells exposed to high glucose concentrations [40][41][42][43][44], and also display glucose lowering properties [45][46][47][48][49][50]. In addition to work by our group [46,48], studies conducted by Kawano et al [51] and Son et al [50] have reported on the effect of pure aspalathin or an aspalathin rich green rooibos extract on the signaling mechanisms that regulate glucose and lipid metabolism in skeletal muscle.…”

Section: Aspalathinmentioning

confidence: 99%

Skeletal Muscle as a Therapeutic Target for Natural Products to Reverse Metabolic Syndrome

Mazibuko-Mbeje¹,

Dludla²,

Nkambule³

et al. 2018

Muscle Cell and Tissue - Current Status of Research Field

View full text Add to dashboard Cite

Natural compounds, especially polyphenols have become a popular area of research mainly due to their apparent health benefits. Increasing the phenolic content of a diet, apart from its antioxidant benefit, has a beneficial effect on signaling molecules involved in carbohydrate and lipid metabolism. These effects could potentially protect against metabolic syndrome, a cluster of metabolic complications such as obesity, insulin resistance and type 2 diabetes that is characterized by a dysregulated carbohydrate, and lipid metabolism. Research continues to investigate various natural compounds for their amelioration of impaired signaling mechanisms that may lead to dysregulated metabolism to find means to improve the life expectancy of patients with metabolic syndrome. In this chapter, a systematic search through major databases such as MEDLINE/PubMed, EMBASE, and Google Scholar of literature reporting on the ameliorative potential of commonly investigated natural products that target skeletal muscle to ameliorate metabolic syndrome associated complications was conducted. The selected natural products that are discussed include apigenin, aspalathin, berberine, curcumin, epigallocatechin gallate, hesperidin, luteolin, naringenin, quercetin, resveratrol, rutin, and sulforaphane.compounds of plant origin have long been shown to possess strong ameliorative properties against various communicable and noncommunicable diseases [1,2]. For example, since its traditional use during the 1950s, artemisinin, an antimalarial qinghao derived lactone, has been the leading therapy for the treatment of Plasmodium falciparum malaria worldwide [3]. Similarly, the traditional use of galegine, an alkaloid isolated from Galega officinalis, led to the discovery of biguanide class of antidiabetic medications such as metformin [4]. Agents such as metformin are effective at lowering blood glucose levels and combating complications associated with insulin resistance (IR), the major characteristic of the metabolic syndrome [5]. However, the continued rise in the mortality of diabetic patients warrants an investigation into alternative therapies to reduce the burden of noncommunicable diseases. Naturally derived compounds such as polyphenols are increasingly explored for their therapeutic potential to reverse IR and thus decrease the risk of developing the metabolic syndrome. This may eventually lead to an increased life expectancy of diabetic individuals [6]. Thus, due to its modulatory effect of glucose and lipid metabolism, skeletal muscle has been a target to a growing number of therapeutic interventions in an effort to reverse IR and improve the management of metabolic syndrome [7,8]. Here, we systematically assessed the available literature on the ameliorative potential of some of the prominent natural products against IR associated complications. A systematic search was conducted on all major databases such as MEDLINE/ PubMed, EMBASE, and Google Scholar, for available literature reporting on the ameliorative properties of some of the promi...

show abstract

Aspalathin and Nothofagin from Rooibos (Aspalathus linearis) Inhibits High Glucose-Induced Inflammation In Vitro and In Vivo

Cited by 66 publications

References 49 publications

Production of dihydrochalcone-rich green rooibos (Aspalathus linearis) extract taking into account seasonal and batch-to-batch variation in phenolic composition of plant material

Production of dihydrochalcone-rich green rooibos (Aspalathus linearis) extract taking into account seasonal and batch-to-batch variation in phenolic composition of plant material

The Effect of Aspalathin on Levels of Sugar and Lipids in Streptozotocin-Induced Diabetic and Normal Rats

Skeletal Muscle as a Therapeutic Target for Natural Products to Reverse Metabolic Syndrome

Contact Info

Product

Resources

About