2015
DOI: 10.1158/1078-0432.ccr-14-1714
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Asparagine Synthetase Polymorphisms and Toxicity and Efficacy of Asparaginases

Abstract: Asparaginases develop innovative “tumor starvation” conditions for all antileukemia treatments; however, administrations are limited by the toxicities of this drug. Patients exhibiting moderate toxicity have optimal treatment outcomes. Certain asparagine synthetase polymorphisms may contribute to severe host toxicities in divergent subsets of patients, whereas others do not. Clinical correlations should be evaluated. Clin Cancer Res; 21(2); 230–2. ©2014 AACR. See related article by Tanfous et al… Show more

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