Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice

Soffritti, Morando; Belpoggi, Fiorella; Manservigi, Marco; Tibaldi, Eva; Lauriola, Michelina; Falcioni, Laura; Bua, Luciano

doi:10.1002/ajim.20896

Cited by 106 publications

(118 citation statements)

References 21 publications

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“…There is, however, a growing body of literature that suggests adverse health effects of ASB (54,55) , and an association between daily intake of artificially sweetened soft drinks and increased risk of preterm delivery has recently been reported in two large population-based prospective studies (22,27) . Some researchers recommend that vulnerable subgroups, such as pregnant women, not to drink ASB (56) .…”

Section: Artificially Sweetened Beveragesmentioning

confidence: 99%

Changes in beverage consumption from pre-pregnancy to early pregnancy in the Norwegian Fit for Delivery study

Skreden

Bere

Sagedal

et al. 2014

Public Health Nutr.

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Objective: To describe changes in consumption of different types of beverages from pre-pregnancy to early pregnancy, and to examine associations with maternal age, educational level and BMI. Design: Cross-sectional design. Participants answered an FFQ at inclusion into a randomized controlled trial, the Fit for Delivery (FFD) trial, in median gestational week 15 (range: 9-20), reporting current consumption and in retrospect how often they drank the different beverages pre-pregnancy. Setting: Eight local antenatal clinics in southern Norway from September 2009 to February 2013. Subjects: Five hundred and seventy-five healthy pregnant nulliparous women. Results: Pre-pregnancy, 27 % reported drinking alcohol at least once weekly, compared with none in early pregnancy (P < 0·001). The percentage of women drinking coffee (38 % v. 10 %, P < 0·001), sugar-sweetened beverages (10 % v. 6 %, P = 0·011) and artificially sweetened beverages (12 % v. 9 %, P = 0·001) at least daily decreased significantly from pre-pregnancy to early pregnancy, while the percentage of women who reported to drink water (85 % v. 92 %, P < 0·001), fruit juice (14 % v. 20 %, P = 0·001) and milk (37 % v. 42 %, P = 0·001) at least daily increased significantly. From pre-pregnancy to early pregnancy higher educated women reduced their consumption frequency of coffee significantly more than women with lower education. Older women reduced their consumption frequency of coffee and artificially sweetened beverages and increased their consumption frequency of fruit juice and milk significantly more than younger women. Conclusions: There is a significant change in beverage consumption from pre-pregnancy to early pregnancy among Norwegian nulliparous women.

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Section: Artificially Sweetened Beveragesmentioning

confidence: 99%

Changes in beverage consumption from pre-pregnancy to early pregnancy in the Norwegian Fit for Delivery study

Skreden

Bere

Sagedal

et al. 2014

Public Health Nutr.

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“…For the Soffritti et al (2010) publication, EFSA noted that the descriptions of the statistical analyses and of the study design (e.g., outcome variable, covariates and assumptions, power calculation, blinding) are not sufficiently detailed, and thus, the relevance of the statistical analyses presented by the authors cannot be assessed at present.…”

Section: Resultsmentioning

confidence: 99%

“…Following a request from the European Commission, the European Food Safety Authority was asked to deliver a scientific statement on a carcinogenicity study in mice with transplacental exposure to aspartame, as reported by Soffritti et al (2010), and on a prospective cohort study on the association between intakes of sugar-sweetened and artificially sweetened soft drinks and preterm delivery in pregnant women, as reported by Halldorsson et al (2010).…”

Section: Resultsmentioning

confidence: 99%

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Statement of EFSA on the scientific evaluation of two studies related to the safety of artificial sweeteners

2011

EFS2

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The European Food Safety Authority was asked to provide scientific advice on two studies, namely a carcinogenicity study in mice (Soffritti et al., 2010) and a prospective cohort study on the association between intakes of artificially sweetened soft drinks and preterm delivery (Halldorsson et al., 2010) and to conclude on the need to revise previous evaluations of aspartame or of the other sweeteners authorised in the European Union. The study by Soffritti et al. (2010) is a long‐term carcinogenicity study in mice with transplacental exposure to the artificial sweetener aspartame. The authors concluded that, based on their results, aspartame induces cancer in the livers and lungs of male Swiss mice. EFSA has evaluated this carcinogenicity study and has concluded that, on the basis of the information available in the publication, the validity of the study and its statistical approach cannot be assessed and that its results cannot be interpreted. Furthermore, in view of the generally recognised lack of relevance for human risk assessment of the type of tumours observed in Swiss mice when they are induced by non‐genotoxic compounds, EFSA concluded that the results presented in Soffritti et al. (2010) do not provide a sufficient basis to reconsider the previous evaluations by EFSA on aspartame. Halldorsson et al. (2010) investigated preterm delivery in a cohort of 59 334 pregnant women. The authors concluded that their results show an association between intake of artificially sweetened soft drinks and preterm delivery in the cohort. EFSA assessed this study and concluded that there is no evidence available to support a causal relationship between the consumption of artificially sweetened soft drinks and preterm delivery and that additional studies are required to reject or confirm an association. Overall, EFSA concluded that the information available from the Soffritti et al. (2010) and Halldorsson et al. (2010) publications do not give reason to reconsider the previous evaluations of aspartame or of other food additive sweeteners authorised in the European Union.

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“…10 Even though case control studies have been reassuring, the general public do have concerns about the carcinogenic potential of artificial sweeteners observed in animal studies. 11 The hypothetical risks of artificial sweeteners such as obesity and carcinogenocity are no less of a concern than the hypothetical risk of tooth decay due to the relatively small amount of sugar in medicines.…”

Section: N B R I E F Opinionmentioning

confidence: 99%

Sugar-free medicines are counterproductive

Sundar

2012

Br Dent J

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Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice

Cited by 106 publications

References 21 publications

Changes in beverage consumption from pre-pregnancy to early pregnancy in the Norwegian Fit for Delivery study

Changes in beverage consumption from pre-pregnancy to early pregnancy in the Norwegian Fit for Delivery study

Statement of EFSA on the scientific evaluation of two studies related to the safety of artificial sweeteners

Sugar-free medicines are counterproductive

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