Aspartate aminotransferase to platelet ratio index (APRI) can predict liver fibrosis in chronic hepatitis B

Shin, Woon Geon; Park, S.H.; Jang, Myoung Kuk; Hahn, Taeho; Kim, J.B.; Lee, M.S.; Kim, D.J.; Jun, Sun-Young; Park, C.K.

doi:10.1016/j.dld.2007.10.011

Cited by 134 publications

(97 citation statements)

References 34 publications

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“…Similar values of AUROC (0.69-0.88) were reported in patients with hepatitis C [11][12][13] whereas they exceed 0.8 in patients with hepatitis B [14].…”

Section: Discussionsupporting

confidence: 64%

APRI as an indicator of advanced liver fibrosis in children with α 1 -antitrypsin deficiency

Bakuła¹,

Dądalski²,

Socha³

et al. 2012

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“…Similar values of AUROC (0.69-0.88) were reported in patients with hepatitis C [11][12][13] whereas they exceed 0.8 in patients with hepatitis B [14].…”

Section: Discussionsupporting

confidence: 64%

APRI as an indicator of advanced liver fibrosis in children with α 1 -antitrypsin deficiency

Bakuła¹,

Dądalski²,

Socha³

et al. 2012

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“…However, most of those studies were carried out in patients with chronic hepatitis C. There are only a few studies evaluating noninvasive models predicting liver fi brosis in CHB, and the results have been controversial or inconsistent (20)(21)(22). The present study evaluated the validity of ten noninvasive methods to distinguish between Ishak stages F ≤ 2 and F ≥ 3 in 158 patients with CHB.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Liver Fibrosis by Ten Noninvasive Methods in Patients with Chronic Hepatitis B: A Comparative Study

Sahin¹,

Süleymanlar²

2018

Akd Med J

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Objective: This study aims to evaluate the predictive value of noninvasive serum markers of hepatic fi brosis in patients with chronic hepatitis B. Material and Methods:This study involved 158 patients with chronic hepatitis B. Noninvasive markers used were as follows; aspartate transaminase (AST) to alanine transaminase (ALT) ratio (AAR), fi brosis-4 (FIB-4) index, age-platelet index (AP), Forns index, cirrhosis discriminant score (CDS), Kings score, Fibro-Q index, PAPAS score, Lok index and red cell distribution width to platelet ratio (RPR). Concurrent liver biopsy specimens were evaluated with the Ishak scoring system. Patients were divided into two groups, those with signifi cant fi brosis (Ishak fi brosis score F ≥ 3) and those without (Ishak fi brosis score F ≤ 2). Receiver operating characteristic (ROC) curve analyses were carried out to compare the results of the noninvasive markers in the two groups.

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“…In univariate analysis, we consistently found that ultrasonographic liver fibrosis (PLD and cirrhosis) was a significant risk factor of erosive esophagitis [N vs. PLD/LC, 158 (16.2%) vs. 8 (32%), P = 0.036]. To examine the effect of liver fibrosis stage on the incidence of GERD in HBV infection, the 75 percentile of APRI (a non-invasive predictor of liver fibrosis and cirrhosis [13][14][15]) was used as a cutoff point. Multivariate analysis showed that HBV carriers with higher APRI levels had an increased risk of erosive esophagitis than those with lower APRI levels (adjusted OR 3.94, 1.73-8.96, P = 0.001) ( Table 5).…”

Section: Factors Affecting the Associations Between Chronic Hbv Infecmentioning

confidence: 99%

Increased incidence of gastroesophageal reflux disease in patients with chronic hepatitis B virus infection

et al. 2010

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Background Although chronic liver disease is associated with gastroesophageal reflux disease (GERD), the impact of chronic hepatitis B virus (HBV) infection on this association remains unclear. We thus aimed to evaluate the relationship between chronic HBV infection and GERD.Methods In this prospective population-based study, 1,001 adult subjects who underwent an upper gastrointestinal endoscopic examination in a health check-up and completed a gastroesophageal reflux questionnaire were consecutively enrolled. Endoscopic findings were classified according to the Los Angeles classification. Hepatitis B surface antigen was used as a marker of HBV infection. Univariate and multivariate approaches were used to evaluate the effects of chronic HBV infection on GERD.Results Chronic HBV infection was associated with heartburn sensation [odds ratio (OR) 1.27, 95% confidence interval 1.01-1.61, P = 0.037], and erosive esophagitis (adjusted OR 1.75, 1.03-2.97, P = 0.037). Although male gender is a risk factor of erosive esophagitis, further analyses stratified by gender and aspartate aminotransferase to platelet ratio index (APRI) showed that chronic HBV infection was associated with erosive esophagitis in female subjects (adjusted OR 2.70, 1.14-6.39, P = 0.024) and those with APRI of more than 0.3 (adjusted OR 3.94, 1.73-8.96, P = 0.001). Moreover, higher serum aspartate aminotransferase (AST) and triglyceride (TG) levels were risk factors of erosive esophagitis in patients with chronic HBV infection. Conclusions Our findings indicate a close association between chronic HBV infection and GERD, especially in female subjects and those with higher APRI levels. Moreover, HBV carriers with higher AST or TG levels have higher incidence of erosive esophagitis. The interactions between chronic HBV infection and GERD need further studies.

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Aspartate aminotransferase to platelet ratio index (APRI) can predict liver fibrosis in chronic hepatitis B

Cited by 134 publications

References 34 publications

APRI as an indicator of advanced liver fibrosis in children with α 1 -antitrypsin deficiency

APRI as an indicator of advanced liver fibrosis in children with α 1 -antitrypsin deficiency

Evaluation of Liver Fibrosis by Ten Noninvasive Methods in Patients with Chronic Hepatitis B: A Comparative Study

Increased incidence of gastroesophageal reflux disease in patients with chronic hepatitis B virus infection

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