Aspartate Aminotransferase-to-Platelet Ratio index (APRi) in infants with biliary atresia: Prognostic value at presentation

Planimetry of the porta hepatis in biliary atresia

“…However, the continuous variable APRi should have detected something if there was indeed a degree of association. We have reported using the APRi previously in 260 infants with BA and showed a correlation with age . We were also able to show differences in APRi according to the aetiological variant, with higher values in those with CMV IgM + associated BA, for instance.…”

“…Anteriorly, the limit was the margin of segment IV and posteriorly the margin of the caudate lobe (segment I). Biological variables included age at time of surgery and biochemical variables included bilirubin, γ‐glutamyl transpeptidase (GGT) and the aspartate amino transaminase‐to‐platelet‐ratio index (APRi), used here as a surrogate of liver fibrosis and disease stage …”

Th-17 cells infiltrate the liver in human biliary atresia and are related to surgical outcome

“…There was a modest correlation between the aspartate aminotransferease platelet ratio index (APRi) (28) and Th-1 (rS = 0.32, P = 0.05).…”

APRi predicts native liver survival by reflecting portal fibrogenesis and hepatic neovascularization at the time of portoenterostomy in biliary atresia

“…Several factors are known to affect outcomes of PE, including patient age and the degree of liver fibrosis at the time of PE [3,4]. Aspartate aminotransferase-to-platelet ratio index (APRi) has been introduced as a useful noninvasive tool to evaluate liver fibrosis and prognosis in BA [5,6]. Less is known about pathophysiological basis for prognostic power of APRi measured at the time of PE.…”