Aspectos da assistência em pacientes com Doença Falciforme no contexto da pandemia da COVID-19

Santos, Olivia Franco dos; Espósito, Thais Sette; Almeida, Rodrigo De Martin; Santos, Augusto Cézar Apolinário dos; Lopes, Jordana Alícia Silveira; Gusmão, Amanda do Carmo; Magalhaes, Neide; Rodrigues, Dow

doi:10.5935/2238-3182.2022e32204

Cited by 2 publications

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“…These manifestations have been reported since the beginning of the pandemic with significant frequency, although the cause-effect correlation cannot always be clearly determined. There are points of disagreement about the biological impact of COVID-19 in individuals with sickle cell disease, but most authors seem to agree that SARS-CoV-2 can act as a trigger for vaso-occlusive crises and acute chest syndrome ( 14 , 29 , 30 , 32 , 34 , 37 , 39 , 42 , 43 , 45 , 46 , 67 , 71 , 72 , 74 , 75 , 77 , 79 , 82 , 84 , 86 , 90 , 92 , 98 , 104 , 106 , 109 , 112 , 118 ). Explanations for this are grounded in empirical data and well-established knowledge about the mechanisms by which infections trigger complications of sickle cell disease.…”

Section: Discussionmentioning

confidence: 99%

“…Blood transfusions, especially exchange transfusions, may benefit individuals with sickle cell disease and COVID-19, especially in the presence of significant anemia and acute chest syndrome ( 56 , 57 , 65 , 74 , 78 , 81 , 84 , 90 , 92 , 106 ). However, there are disagreements regarding the early or prophylactic use of this measure.…”

Section: Discussionmentioning

confidence: 99%

“…Vaccination, an essential tool for reducing mortality from infectious causes in this population, should also be encouraged in all age groups, as it has been for the general population ( 2 , 47 , 106 ). Studies show that there may be some hesitation among people with sickle cell disease regarding the safety profile of immunizers against SARS-CoV-2 and the occurrence of adverse effects ( 121 ).…”

Section: Discussionmentioning

confidence: 99%

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Impact of the SARS-CoV-2 infection in individuals with sickle cell disease: an integrative review

et al. 2023

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Sickle cell disease is the most common hemoglobinopathy among humans. As the condition promotes susceptibility to infections, chronic inflammation, and hypercoagulability disorders, several international agencies have included individuals with this disease in the COVID-19 risk group for severe outcomes. However, available information about the subject is not properly systematized yet. This review aimed to understand and summarize the scientific knowledge about the impact of SARS-CoV-2 infection in patients with sickle cell disease. Searches were performed in the Medline, PubMed, and Virtual Health Library databases based on descriptors chosen according to the Medical Subject Headings. We analyzed studies published between 2020 and October 2022, developed with qualitative, quantitative, or mixed methodology, and written in English, Spanish, or Portuguese. The search resulted in 90 articles organized into six categories. There is disagreement in the literature about how different aspects related to sickle cell disease, such as chronic inflammation status, hypercoagulability, hemolytic anemia, use of hydroxyurea, and access to medical care interference with the clinical course of COVID-19. These topics deserve further investigation. It is evident, however, that the infection may manifest in an atypical way and act as a trigger for the development of sickle cell-specific complications, such as acute chest syndrome and vaso-occlusive crises, conditions that are associated with great morbidity and mortality. Therefore, healthcare professionals must be aware of the different forms of presentation of COVID-19 among these individuals. Specific guidelines and therapeutic protocols, as well as public policies for sickle cell individuals, must be considered.Systematic review registrationThis review (https://doi.org/10.17605/OSF.IO/NH4AS) and the review protocol (https://osf.io/3y649/) are registered in the Open Science Framework platform.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Impact of the SARS-CoV-2 infection in individuals with sickle cell disease: an integrative review

et al. 2023

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“…A DF é uma doença de herança monogênica autossômica recessiva, devido a uma mutação no gene da β globina no cromossomo 11. A mutação é "de ponto" e de sentido trocado, na qual há a substituição de um ácido glutâmico (GAG) por uma valina (GTG) na sexta posição da cadeia β da hemoglobina, produzindo a hemoglobina S com características estruturais e bioquímicas alteradas (SANTOS et al, 2022).…”

Section: Introductionunclassified

Análise Do Perfil Hemoglobínico Das Hemoglobinopatias Em Recém-Nascidos Em Uma Cidade Da Amazônia

Santos,

SANTOS,

VAZ

2024

Anais Do II Congresso Nacional De Pesquisas E Estudos Genéticos

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Aspectos da assistência em pacientes com Doença Falciforme no contexto da pandemia da COVID-19

Cited by 2 publications

References 0 publications

Impact of the SARS-CoV-2 infection in individuals with sickle cell disease: an integrative review

Impact of the SARS-CoV-2 infection in individuals with sickle cell disease: an integrative review

Análise Do Perfil Hemoglobínico Das Hemoglobinopatias Em Recém-Nascidos Em Uma Cidade Da Amazônia

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