ASPECTOS QUÍMICOS E ATIVIDADE ANTIBACTERIANA DE &lt;I&gt;PIPTADENIAGONOACANTHA&lt;/I&gt; (FABACEAE)

Carvalho, Camilo Amaro de; Santana, Gabriela Silva; Amaro, Marilene de Oliveira Fani; Lima, Luciana Moreira; Pires, Fernanda Brum; Prá, Valéria Dal; Cardoso, Sílvia Almeida; Rosa, Marcelo Barcellos da; Oliveira, Leandro Licursi de

doi:10.5902/2179460x13456

Cited by 4 publications

(18 citation statements)

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“…Thus, the phytochemical analysis revealed the presence of flavonoids, phenolics, tannins, anthraquinone, saponins, coumarins, and cardiotonic glycosides. Carvalho et al (2014) evaluated hydroalcoholic compounds at 80% (v/v) extracted from P. gonoacantha leaves and found the same compounds, corroborating results presented here. According to Leão (2007), such compounds are called secondary metabolites and are related to the chemical plant defense, guaranteeing their survival in their natural habitat.…”

Section: Resultssupporting

confidence: 86%

“…On the other hand, the decrease of these cells in the group treated with the highest dose of the extract can be explained, according to Melo et al (2008), due to the greater amount of tannins ingested by the animals, since this compound is responsible for the decrease in the total number of lymphocytes. In addition, the anti-inflammatory activity of hydroalcoholic extracts produced from the plant leaves was previously demonstrated in studies carried out by Carvalho et al (2014), justifying the decrease of these cells. Significant histopathological alterations (p<0.05) were found only in animals treated with ivermectin 1%.…”

Section: Resultsmentioning

confidence: 79%

“…On the other hand, it can be inferred that the presence of other secondary metabolites is related to the lysis verified under light microscopy. According to Oliveira et al (2011), the active compounds of plants have been widely studied for the control of intestinal parasites, emphasizing the tannins, which are the secondary metabolites most found in plants. In their condensed form, tannins have the ability to bind and alter physicochemical properties of proteins (Hoste et al, 2006).…”

Section: Resultsmentioning

confidence: 99%

“…EAM was obtained after 1 h at room temperature, and the EAU, obtained under the same conditions, however, subjected to ultrasound (Unique ® -MaxiClean 1400), following methodology used by Carvalho et al (2011). Extracts were filtered separately under vacuum to remove completely dry matter, obtaining maximum solution volume.…”

Section: Extracts Preparationmentioning

confidence: 99%

“…According to the World Health Organization (WHO), 85% of the population of developing countries uses medicinal plants in nature or herbal formulations. However, in order to be used for this purpose, it is important to identify which pharmacological principles are present in the vegetal species and whether they have toxic components that could create risks to animal and human health (Simões et al, 2004;Carvalho et al, 2014). Therefore in vivo and in vitro tests must be performed to evaluate their effects (Mellor, 2000).…”

Section: Introductionmentioning

confidence: 99%

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Anthelmintic potential and in vivo acute toxicity study of Piptadenia gonoachanta leaf aqueous extract

2017

J App Pharm Sci

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Piptadenia gonoacantha (Leguminosae) is an arboreal species found in southern and southeastern Brazil. Several compounds have been identified in their leaves, such as anthraquinones, phenolics, tannins, saponins, coumarins and flavonoids. The presence of these metabolites is associated with antioxidant, anti-inflammatory, antibiotic and anthelmintic properties. This study evaluated the phytochemical profile of in vitro anthelmintic activity and in vivo toxicity of the aqueous extract of P. gonoacantha leaves. The extracts were distinctly evaluated by extraction method: maceration (EAM), ultrasonication (EAU) and lyophilization (EAL). Anthelmintic activity analysis was carried out for all preparations at 25, 50 and 100 mg.mL -1 against Panagrellus sp. in an in vitro assay. In vivo toxicity was assessed by biochemical, hematological and histological evaluation of Balb/C mice treated orally with EAU (100, 200 and 400 mg.Kg -1 ) for 10 consecutive days. Phytochemical analysis showed the presence of tannins, flavonoids, coumarins, saponins, glycosides, phenolic compounds and anthraquinone. Anthelmintic potential showed significant results, with inhibition potential ranging from 93.93% and 99.88% among the different concentrations and preparations tested. In absolute values, the EAPG at 50 mg / mL showed a higher percentage of inhibition, reaching the following concentrations: 25, 50 and 100 mg / mL of preparation I (EAM), 25 and 100 mg / mL of preparation II (EAU) and 25 , 50 and 100 mg / mL of preparation III (EAL), had percentage of inhibition of 99.39%, 96.15%, 96.57%, 96.45%, 95.01%, 99.74% and 99% 44% respectively. EAU has proved to be safe for in vivo use because it showed low toxicity, enabling it to future pre-clinical and clinical studies.

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Section: Resultssupporting

confidence: 86%

Section: Resultsmentioning

confidence: 79%

Section: Resultsmentioning

confidence: 99%

Section: Extracts Preparationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anthelmintic potential and in vivo acute toxicity study of Piptadenia gonoachanta leaf aqueous extract

2017

J App Pharm Sci

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INTERFERÊNCIA DO EXTRATO DE Hymenaea courbaril L. (JATOBÁ) NA ATIVIDADE ANTIBACTERIANA DE AMINOGLICOSÍDEOS

Camilo¹,

Nonato²,

Silva³

et al. 2020

Rev. Interfaces

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Hymenaea courbaril L. (Jatobá) pertencente à família Fabaceae apresenta larga utilização no setor florestal, sendo seu caule o produto mais comercializado por apresentar madeira de alta densidade e resistência ao ataque de organismos decompositores no Brasil, essa espécie ocorre naturalmente deste o estado do Piauí até o Norte do Paraná. O Jatobá é muito utilizado na medicina para o tratamento de diferentes infermidades. Esse trabalho teve como objetivo avaliar a atividade antibacteriana e moduladora de aminoglicosídeos pelo extrato das cascas dos frutos do jatobá, e ainda realizar screening fitoquímico para averiguar as principais classes de metabólitos secundários presentes. Os ensaios frente às bactérias seguiram o método de microdiluição em caldo BHI. Os testes químicos foram realizados qualitativamente pela adição de ácidos e bases. Como resultado a análise antibacteriana do extrato mostrou-se eficiente para todas as linhagens, principalmente frente a espécie Staphylococcus aureus. A modulação dos antibióticos pelo extrato mostrou sinergismo contra todas as espécies bacterianas testadas, reduzindo significativamente os valores de CIM. A prospecção química revelou que o extrato do Jatobá, em estudo, contém compostos pertencentes á classes de flavonóides. Conclui-se que a espécie em estudo mostrou-se promissora como antimicrobiano natural, sendo importante a investigação quanto aos seus mecanismos de ação.

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Técnicas De Prospecção Fitoquímica E Sua Importância Para O Estudo De Biomoléculas Derivadas De Plantas

Soares¹,

Santos²,

Vieira³

et al. 2016

Enci Bio

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RESUMOAs plantas medicinais são utilizadas desde a antiguidade e esse conhecimento tradicional é passado pelas gerações e podem orientar o estudo de moléculas bioativas, na pesquisa de princípios ativos ou na produção de medicamentos. Os metabólitos secundários são compostos químicos produzidos pelas plantas derivados do metabolismo primário da glicose e atuam na ecologia dos vegetais por meio de funções como atração de polinizadores e dispersores, defesa contra herbivoria e radiação entre outras. A fitoquímica atua no estudo dos metabólitos secundários e a prospecção fitoquímica irá detectar a presença desses e, com isso, orientar as demais etapas do estudo dos vegetais para produção de medicamentos e fitoterápicos. A prospecção pode ser realizada por testes de reações químicas ou por métodos cromatográficos. Os primeiros possuem baixo custo e são mais simples, os segundos necessitam de equipamentos dispendiosos e treinamento adequado para utilização, porém, são mais eficazes no estudo e podem ser utilizados nas demais etapas da investigação fitoquímica. Atualmente, os métodos mais utilizados são por reações químicas e investigações adicionais são realizadas juntamente com a prospecção fitoquímica. Tais estudos são importantes para a pesquisa farmacêutica, para a filogenética e principalmente na preservação dos recursos vegetais dos diferentes biomas brasileiros. PALAVRAS-CHAVE: Farmacognosia, metabolismo vegetal, Plantas medicinais; Química experimental. PHITOCHEMICAL PROSPECTING TECHNIQUES AND THEIR IMPORTANCE TO THE STUDY OF BIOMOLECULAS DERIVED FROM PLANTSABSTRACT Medicinal plants have been used since ancient times and that traditional knowledge is passed through generations and can guide the study of bioactive molecules in the active ingredients research or the production of medicines. Secondary metabolites are chemical compounds produced by plants derived from primary metabolism of glucose and act on the plant ecology through functions such as attracting pollinators

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ASPECTOS QUÍMICOS E ATIVIDADE ANTIBACTERIANA DE <I>PIPTADENIAGONOACANTHA</I> (FABACEAE)

Abstract: Resumo Este trabalho teve o objetivo de avaliar os aspectos fitoquímicos e antibacteriano de 40°C using 80% ethanol (v/v)

Cited by 4 publications

References 2 publications

Anthelmintic potential and in vivo acute toxicity study of Piptadenia gonoachanta leaf aqueous extract

Anthelmintic potential and in vivo acute toxicity study of Piptadenia gonoachanta leaf aqueous extract

INTERFERÊNCIA DO EXTRATO DE Hymenaea courbaril L. (JATOBÁ) NA ATIVIDADE ANTIBACTERIANA DE AMINOGLICOSÍDEOS

Técnicas De Prospecção Fitoquímica E Sua Importância Para O Estudo De Biomoléculas Derivadas De Plantas

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