Aspects chimiques de l’endolymphe et de la périlymphe

Rauch, Sigurd; Köstlin, Annemarie

doi:10.1159/000274155

Cited by 9 publications

(6 citation statements)

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“…(a) Endolymph and Perilymph Several authors have measured the electrolytic (e.g., Smith et a!., 1954;Citron et a!., 1956;Rauch, 1958Rauch, , 1964Rauch and Kostlin, 1958;Murray and Potts, 1961;Fernandez, 1967;reviewed by Trincker, 1962, and Lowenstein, 1974 and physical (e.g., Kaieda, 1930;Rossi, 1914;von Bekesy, 1960;Money eta!., 1966Money eta!., , 1971Steer, 1967;Steer eta!., 1967;ten Kate, 1969;ten Kate et a!., 1970) properties of the endolymph and perilymph, summarized results having been shown in Table 2-1 of Chapter 2. For the present purpose, note that the two fluids appear to be of slightly different density and that they are physically separate from one another.…”

Section: The Real Semicircular Canalmentioning

confidence: 99%

Mammalian Vestibular Physiology

Wilson¹,

Jones²

1979

698

203

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Ali rights reservedNo part of this book may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, microfllming, recording, or otherwise, without written permission from the Publisher PrefaceIt is easy to underrate the importance of a sensory system whose receptor is buried deep within the skull and of whose performance we are usually not aware. It is only when it malfunctions that we know we have a vestibular system! Unraveling the mechanisms by which activation of the vestibular labyrinth exerts its varied effects presents a great challenge, which increasing numbers of investigators are rushing to meet. At this time a period of transition appears to have been reached. On the one hand, physiological and anatomical techniques have provided extensive information about the properties of the receptor and of some of the pathways that link it to the musculature. On the other hand, extensive behavioral and psychophysical studies provide different insights into the mechanisms involved in vestibular reflexes. Until recently there has been relatively 1ittle interaction between the practitioners of these two widely different approaches. It has been our goal to assess and describe the progress that has been made in both areas and, when possible, to make a synthesis of the results. As will be seen, numerous questions are raised in the process, and we hope that they will help in pointing the way to further investigations.

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Section: The Real Semicircular Canalmentioning

confidence: 99%

Mammalian Vestibular Physiology

Wilson¹,

Jones²

1979

698

203

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“…Endolymph, in particular, is striking in its similarity to intracellular fluid composition and large positive potential with reference to perilymph. 1,2 The high potassium and low sodium concentrations, along with the +80 mV potential of endolymph, are thought to be essential to normal signal transduction by the cochlea and vestibular apparatus. 3,4 The clinical significance of this inner ear homeostasis is readily apparent in instances where the regulatory processes fail (as suggested in some cases of Meniere's disease).…”

Section: Introductionmentioning

confidence: 99%

Developmental Expression of Aquaporin 2 in the Mouse Inner Ear

et al. 2000

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Objectives:The maintenance of endolymph homeostasis is critical for the inner ear to perform its functions of hearing and maintaining balance. The identification and cloning of aquaporins (a family of water channel proteins) has allowed the study of a novel cellular mechanism potentially involved in endolymph homeostasis. The objective of the present study was to define the developmental temporal and spatial expression pattern of aquaporin 2 (Aqp2) in the developing mouse inner ear. Study Design: A systematic immunohistochemical study of Aqp2 protein expression was performed on embryonic mouse inner ears ranging from embryonic day 10 (otocyst stage) to embryonic day 18 (just before birth). Methods: Serial cryosections of embryonic mouse inner ears were used for immunohistochemical experiments. A rabbit polyclonal antisera raised against a synthetic Aqp2 peptide was used with a standard nickel intensified 3,3-diaminobenzidine reaction protocol for immunolocalization of Aqp2 in tissue sections. Results: Aquaporin 2 is expressed diffusely in the early otocyst, then becomes progressively restricted as the inner ear matures. During early cochlear duct formation (embryonic days 12 and 13), expression of Aqp2 is homogeneous; later, it becomes restricted to specific regions of the endolymphatic compartment (embryonic days 15 and 18). Similar restriction of expression patterns could be noted for the vestibular structures. Endolymphatic duct and sac and stria vascularis expression of Aqp2 was noted to occur fairly late during development but demonstrated a distinct pattern of immunolabeling. Conclusions: Aquaporin 2 shows an early and specific pattern of expression in the developing mouse inner ear, suggesting a significant role for this water channel protein in the development of endolymph homeostasis and meriting further functional studies of Aqp2 in the inner ear.

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“…[22][23][24] The relationship between the electrolyte levels of the endolymph and the bio-electric potentials of the cochlear duct is not clear at this time. [22][23][24] The relationship between the electrolyte levels of the endolymph and the bio-electric potentials of the cochlear duct is not clear at this time.…”

Section: Osseous Spiral Laminamentioning

confidence: 97%

LII Experimental Observations on the Fluid Physiology of the Inner Ear

Schuknecht¹,

Seifi²

1963

Ann Otol Rhinol Laryngol

135

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A series of animal experiments have been performed in an attempt to clarify the origin and fate of endolymph and perilymph, to determine possible pathways of fluid flow, and to attempt to discover the function of the cochlear aqueduct and endolymphatic sac. A. THE COCHLEAR AQUEDUCTThe cochlear aqueduct is a bony channel extending from the scala tympani of the basal turn near the round window to the cranial cavity near the ganglion of the glossopharyngeal nerve." Within the aqueduct is a loose network of connective tissue continuous with the arachnoid and extending into the scala tympani onto the round window membrane. This membranous tube may be termed the periotic duct; however, for simplicity, we will refer to the combined bony and membranous channel as the cochlear aqueduct.

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Aspects chimiques de l’endolymphe et de la périlymphe

Cited by 9 publications

References 0 publications

Mammalian Vestibular Physiology

Mammalian Vestibular Physiology

Developmental Expression of Aquaporin 2 in the Mouse Inner Ear

LII Experimental Observations on the Fluid Physiology of the Inner Ear

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