Aspects épidémiologiques du diabète de type 1 à la banque d’insuline de Cotonou (Bénin)

Fagbemi, Kaossarath A.; Azonbakin, Simon; Adjagba, Marius; Baba-Moussa, Lamine; Laleye, Anatóle

doi:10.4314/ijbcs.v11i3.13

Cited by 3 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our data corroborate with those found in the literature. [13,14] This can be explained by the fact that T1D is an autoimmune disease caused by the breakdown of tolerance, leading to activated CD4, CD8, and CD28 T lymphocytes, which then change their differentiation pathway to an effector phenotype, thus participating in the destruction of pancreatic β-cells. [15,16] It is also important to consider the role of CMV; multivariate analysis showed that the odds ratio was relatively higher, indicating that (T1D+CMV+) subjects have a 3 times higher chance of having elevated plasma concentrations of CD4, CD8, and CD28 T lymphocytes.…”

Section: Resultsmentioning

confidence: 99%

Type 1 Diabetes and Cytomegalovirus Infection: Cytokine and T Lymphocytes Profile in Pointe Noire, Congo

ATANDI BATCHY,

Charley Elenga-Bongo,

Luc Magloire Anicet Boumba

et al. 2023

JETROMI

View full text Add to dashboard Cite

Background: Type 1 Diabetes (T1D) is an autoimmune disease characterized by the destruction of beta cells in the pancreatic islets of Langerhans. This study aimed to investigate the T lymphocyte pathway involved in cytomegalovirus (CMV) infection in T1D patients in the context of. in Pointe Noire Method: We conducted an analytical case-control study over 6 months between June and November 2022. A total of 234 subjects were enrolled, including 68 (T1D +CMV+) cases, 62 (T1D +CMV-) cases, and 104 healthy subjects as the control group (healthy controls). The plasma concentrations of CD4, CD8, CD28, IL2, IL4, and IL10 were measured using ELISA. Linear regression analysis was performed to explore the correlation between T lymphocyte types (CD4, CD8, and CD28) and interleukins. Results: In the case group, the average age was 20.85±0.63 years for (T1D+CMV+) cases, 21.88±4.07 years for (DT1+CMV-) and 31.95±2.13 years for healthy controls. Men were the majority in the study, representing 55.38%, with a male-to-female ratio of 1:2. Plasma concentrations of different types of lymphocytes were higher in the case group compared to the controls CD4 (7,21±0,23 vs 5,71±3,27 vs 2,07±0,14; p<0,0001); CD8 (13,73±0,91 vs 10,01±1,88 vs 1,27±0,14 p <0,0001); CD28 (45.95±2.18 vs 14.39±1.99 vs 7.97±1.96; p<0,0001); IL2 (1048.0±43.47 vs 252.0±10.91 vs 52.91±23.95; p<0,0001); IL4 (474.3±18.45 vs 279.3±169.2 vs 194.9±136.2); IL10 (275.0±134.0 vs 206.0±84.77 vs 44.62±7.22; p <0,0001), and (CD4, CD8, CD28, IL2, IL4, and IL10) showed significant elevation in the case group compared to the controls. The study also revealed a direct correlation between CD4 and CD28. Conclusion: These findings suggest that CMV infection worsens T1D by promoting the increase in CD4, CD8, and CD28 lymphocytes as well as plasma concentrations of interleukins (IL2, IL4, and IL10), and no correlation was observed with CD8.

show abstract

Section: Resultsmentioning

confidence: 99%

Type 1 Diabetes and Cytomegalovirus Infection: Cytokine and T Lymphocytes Profile in Pointe Noire, Congo

ATANDI BATCHY,

Charley Elenga-Bongo,

Luc Magloire Anicet Boumba

et al. 2023

JETROMI

View full text Add to dashboard Cite

show abstract

“…Avec une proportion plus importante de diabète du type 2. Au Benin ils étaient à 98,8% contre 0,9% du diabète de type 1 (Fagbemi et al, 2017 ;Suvi et al, 2017). Le pré-diabète se caractérise par des anomalies de la glycorégulation avec une glycémie à jeun supérieure ou égale à 6,1 mmol/l (110 mg/dl), mais inférieure à 7,0 mmol/l (126 mg/dl) selon l'Organisation Mondiale de la Santé (OMS).…”

Section: Introductionunclassified

Prévalence du pré-diabète et du diabète avec profil lipidique évalué, en milieu hospitalier urbain: étude rétrospective sur 3538 patients reçus au CHU Campus de Lomé

Kouassi¹,

Feteke²,

Etassoli³

et al. 2020

Int. J. Bio. Chem. Sci

View full text Add to dashboard Cite

Les sujets en état de pré-diabète sont exposés à un risque élevé de diabète et de dyslipidémies. La présente étude avait eu pour but de mesurer la prévalence du pré-diabète et du diabète chez des sujets reçus à l’hôpital, puis de déterminer le profil lipidique des pré-diabétiques. Il s’est agi d’une étude rétrospective à visée descriptive, portant sur 3538 patients âgés de 3 à 120 ans, reçus en 2013 au Centre Hospitalier Universitaire nommé Campus. La glycémie, la cholestérolémie totale, la HDL-Cholestérolémie, et la triglycéridémie ont été dosées sur l’automate SELECTRA PRO M. La non-HDL- Cholestérolémie a été calculée. La prévalence du pré-diabète a été déterminée suivant les critères de l’Organisation Mondiale de la Santé (OMS) et du « American Diabetes Association » (ADA). La prévalence du pré-diabète suivant les critères de l’OMS était de 8,1% contre 21,5% selon les critères de l’ADA. La prévalence du diabète était de 12,9%. Elle était de 15,3% chez les sujets âgés de 45 à 59 ans. Au sein de la population pré-diabétique 42,3 à 45,6% avaient des dyslipidémies. La prévalence du pré-diabète à l’hôpital était importante. Une prise en charge de ce dernier permettrait de prévenir le diabète de type 2 et réduire les risques de dyslipidémies. Mots clés : Glycémie, dyslipidémies, pré-diabétiques, Togo. English Title: Prevalence of pre-diabetes and diabetes with evaluated lipid profile, in urban hospital: retrospective study on 3538 patients seen at the Lomé campus university hospital. People with pre-diabetes are at high risk for diabetes and dyslipidemia. The aim of the present study was to measure the prevalence of pre-diabetes and diabetes in hospital patients, and then to determine the lipid profile of pre-diabetics. It was a retrospective descriptive study, involving 3538 patients aged 3 to 120 years, received in 2013 at the University Hospital Center called Campus. Blood glucose, total cholesterol, HDL-Cholesterolemia, and triglyceridemia were measured on the SELECTRA PRO M automatic analyzer. Non-HDL-Cholesterolemia was calculated. The prevalence of pre-diabetes was determined according to the criteria of the World Health Organization (WHO) and the "American Diabetes Association" (ADA). The prevalence of pre-diabetes according to WHO criteria was 8.1% compared to 21.5% according to ADA criteria. The prevalence of diabetes was 12.9%. It was 15.3% in subjects aged 45 to 59 years. In the pre-diabetic population 42.3 to 45.6% had dyslipidemia. The prevalence of pre-diabetes in hospital was high. Management of the latter would prevent type 2 diabetes and reduce the risk of dyslipidemia. Keywords: Glycemia, dyslipidemia, pre-diabetics, Togo.

show abstract

Barriers and strategies in care delivery for type 1 diabetes in Sub-Saharan Africa: a scoping review

Kentsop,

Zarowsky,

Von Oettingen

2024

Preprint

View full text Add to dashboard Cite

Background: Type 1 diabetes is one of the most common chronic diseases in children. More than 1.2 million young people under the age of 20 are affected, the majority of whom live in low-income countries. The delivery of care for type 1 diabetes at both clinical and health system levels in Sub-Saharan Africa is an important element of protecting child health, preventing complications of type 1 diabetes, and supporting families among vulnerable populations. The successful implementation of effective care delivery requires considering a variety of obstacles and using effective and contextually appropriate strategies to overcome them. This scoping review describes and categorizes the most important barriers to type 1 diabetes care delivery in Sub-Saharan Africa and provides an overview of the types of strategies that are used to overcome these barriers. Methods: We identified 524 articles including peer reviewed publications, gray literature, and documents from agency sites in 5 different databases published from 1990 until the end of 2020. A total of 38 articles were included in the data synthesis. The content was analyzed using a qualitative synthesis approach. Results: Barriers to the care delivery of type 1 diabetes in Sub-Saharan Africa are related to contextual factors at several levels: health system, policy, structure and performance, patient factors, and socio-cultural factors. The core elements of successful strategies for care delivery of type 1 diabetes in Sub-Saharan Africa are education (glycemic management), staff training, and social support (social interaction). Conclusions:Available evidence indicates that structured care delivery can improve the health of people living with type 1 diabetes in Sub-Saharan Africa. Obstacles in the case and population care delivery of type 1 diabetes and the health of people living with type 1 diabetes need to be analyzed before strategies adapted to the context and specific target groups can be developed.

show abstract

Aspects épidémiologiques du diabète de type 1 à la banque d’insuline de Cotonou (Bénin)

Cited by 3 publications

References 13 publications

Type 1 Diabetes and Cytomegalovirus Infection: Cytokine and T Lymphocytes Profile in Pointe Noire, Congo

Type 1 Diabetes and Cytomegalovirus Infection: Cytokine and T Lymphocytes Profile in Pointe Noire, Congo

Prévalence du pré-diabète et du diabète avec profil lipidique évalué, en milieu hospitalier urbain: étude rétrospective sur 3538 patients reçus au CHU Campus de Lomé

Barriers and strategies in care delivery for type 1 diabetes in Sub-Saharan Africa: a scoping review

Contact Info

Product

Resources

About