Aspects épidémiologiques et cliniques des cancers oculaires primitifs du mélanoderme : notre expérience à propos de 111 cas

Seck, Sidy Mohamed; Agboton, G.; Guèye, N.N.; Diop, Jean Pascal Demba; Seck, C.M.; Lam, Alexander

doi:10.1016/j.jfo.2014.06.007

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…The average age of our patients was 44.3 years with extremes of 12 and 87 years. This malignant tumor of the conjunctiva would generally appear in elderly subjects as reported by Seck [7] and Chebbi [13] who had noted respective average ages of 50 years and 62 years. The resurgence in young adults in our study would be linked to the HIV pandemic; which is also the antecedent mainly observed in our patients (64.71%).…”

Section: • Agesupporting

confidence: 53%

“…The frequency of malignant ocular tumors was 0.23% in our series. Kasongo Open Journal of Ophthalmology [6] in the DRC noted 0.24%, while Seck [7] in Senegal found 0.05%. The low incidence of malignant ocular tumors in our Sahelian regions could be explained by the low attendance rate at health centers for financial reasons and the scarcity of specialized centers [8], leading to an underestimate of the incidence of these conditions.…”

Section: • Frequencymentioning

confidence: 99%

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Epidemio-Clinical-Histopathological Aspects and Therapeutics of Squamous Cell Carcinoma of the Conjunctival at the University Hospital Center of Bouake

Bile,

Djiguimde,

Diomandé

et al. 2024

OJOph

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Introduction: Squamous cell carcinoma of the conjunctiva is one of the most common malignancies in the elderly. Purpose: To describe the specific aspects of squamous cell carcinoma of the conjunctiva and to determine the therapeutic modalities. Materials and Methods: Descriptive cross-sectional retrospective study carried out at the University Hospital Center of Bouake over a period of 9 years (From January 2015 to December 2023). We identified all malignant oculo-adnexal and orbital tumors whose histopathological diagnosis was confirmed; monitoring the sorting of squamous cell carcinomas of the conjunctiva among these cancers and studying the different parameters linked to them. Results: The average age of patients is 44.3 years. Male predominance with a sex ratio of 1.12. HIV was the majority ATCD with 64.7%. The main reason for consultation was exophthalmos (36.11%). The average consultation time was 10 months 13 days. Invasive differentiated conjunctival squamous cell carcinoma was predominant at 55.56%. Enucleation was the most performed surgical method. Conclusion: Squamous cell carcinoma of the conjunctiva is a malignant ocular tumor of the elderly whose frequency increases in young adults infected with HIV-AIDS. Invasive differentiated forms are increasingly encountered, limiting treatment to mutilating surgery.

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Section: • Agesupporting

confidence: 53%

Section: • Frequencymentioning

confidence: 99%

Epidemio-Clinical-Histopathological Aspects and Therapeutics of Squamous Cell Carcinoma of the Conjunctival at the University Hospital Center of Bouake

Bile,

Djiguimde,

Diomandé

et al. 2024

OJOph

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Clinical characteristics, HIV status, and molecular biomarkers in squamous cell carcinoma of the conjunctiva in Ghana

Merz

Afriyie

Jiagge

et al. 2019

Health Science Reports

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Background and aims Conjunctival squamous cell carcinoma (CSCC) varies in incidence geographically from 0 to 1 case per 100 000 per year globally. Additionally, the incidence of CSCC is known to increase 49% for every 10° decrease in latitude. Since the onset of the AIDS epidemic, there has been a trend of increasing incidence of CSCC in Africa, and despite relatively stable levels of ultraviolet (UV) exposure, there is an observed 12 times greater risk of developing CSCC when individuals are infected with HIV. In this study, we aim to analyze the clinical characteristics and biomarkers of CSCC in Ghana. Methods In this study, a registry review of patients from January 2011 to May 2016 with CSCC at Komfo‐Anokye Teaching Hospital in Kumasi, Ghana, was performed (n = 64). Tumor blocks of the CSCC were analyzed for the expression of various biomarkers. Results In this study, the median age of onset of CSCC is 46.5 years old (range of 20–90 y old). Fifty one and a half percent (n = 33) of the cohort is female. There is a low rate of smoking and alcohol use in our CSCC cohort. Thirty‐nine percent (n = 12) of Ghanaian men with CSCC are HIV−, while only 12% (n = 4) of women are HIV−. Fifteen patients had metastasis to lymph nodes or other tissues, and we observed a statistically significant relationship between HIV infection and metastasis (P = 0.027, chi‐squared test). We observed no statistically significant relationship between known prognostic CSCC biomarkers and HIV status, age, or tumor stage. Conclusion Better characterization of CSCC could have a profound impact on the prevention, early identification, and treatment of CSCC in Africa. A retrospective chart analysis and collection of tumor samples can be challenging in this region due to methods of record keeping and stigma attached to clinical data such as HIV testing and smoking and alcohol use. As a result, in this study, data were often incomplete leading to inconclusive results and analysis that should be interpreted with caution. Future studies should consider a prospective study design that gathers clinical data in a standardized format and ensures fresh tissue from CSCC tumors.

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L’intérêt du lambeau de rotation temporo-jugal dans la chirurgie de l’épithélioma basocellulaire géant de la paupière inférieure

Seck

Loum

Agboton

et al. 2017

Journal Français d'Ophtalmologie

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Aspects épidémiologiques et cliniques des cancers oculaires primitifs du mélanoderme : notre expérience à propos de 111 cas

Cited by 5 publications

References 7 publications

Epidemio-Clinical-Histopathological Aspects and Therapeutics of Squamous Cell Carcinoma of the Conjunctival at the University Hospital Center of Bouake

Epidemio-Clinical-Histopathological Aspects and Therapeutics of Squamous Cell Carcinoma of the Conjunctival at the University Hospital Center of Bouake

Clinical characteristics, HIV status, and molecular biomarkers in squamous cell carcinoma of the conjunctiva in Ghana

L’intérêt du lambeau de rotation temporo-jugal dans la chirurgie de l’épithélioma basocellulaire géant de la paupière inférieure

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