Aspects of Cardiac Venous Flow Measured by the Continuous Infusion Thermodilution Technique

Simonsen, Svein

doi:10.1159/000169839

Cited by 18 publications

(9 citation statements)

References 13 publications

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“…For this purpose a 0 9 per cent saline solution at room temperature was infused into the great cardiac vein with a Harvard infusion pump at a constant rate of 36 ml/min for 20 to 30 seconds. This method has been found to be reliable for determination of great cardiac venous blood flow in our laboratory with a mean difference between duplicate measurements performed within 1 minute of 3-6 per cent of mean flow (Simonsen, 1977). Pressures were measured by Elema-Sch0nander EMT 35 transducers and recorded on a Mingograph 800 ink-jet recorder.…”

Section: Measurementsmentioning

confidence: 99%

Effect of atenolol (ICI 66 082) on coronary haemodynamics in man.

Simonsen¹

1977

Heart

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The coronary haemodynamic effect of atenolol, a new cardioselective beta-adrenergic blocker, was studied in 15 patients with angina pectoris.Myocardial blood flow from the anterolateral part of the left ventricle was measured by the continuous infusion thermodilution method by means of a two-thermistor catheter with pacing electrodes placed in the great cardiac vein. Catheters were also positioned in the pulmonary artery and the thoracic aorta for blood sampling, pressure measurements, and cardiac output determination. Investigations were performed at rest, at slow, and at submaximal atrial pacing rates before and 10 minutes after injection of 5 mg atenolol intravenously. Coronary angiography was performed in all patients.Atenolol reduced resting myocardial blood flow by 16 per cent (P<0-001) and oxygen consumption by 17 per cent (P<0-001). Flow was reduced whether or not the part of myocardium in question was supplied by a stenotic artery. Coronary arteriolar resistance increased by 23 per cent (P<0 001). Myocardial arteriovenous oxygen difference was not affected. Heart rate and rate-pressure index were reduced in all patients (P<0-001). When the heart rate was kept constant by atrial pacing there was no change in the rate-pressure index and no change in any of the coronary haemodynamic values. A small but highly significant increase of 2 mmHg± 0*4 (SEM) in left ventricularfilling pressure was observed at rest (P<0-001), and 4 mmHg± 07 (P=0-001) during submaximal pacing. In all three situations theflow per unit left ventricular pressure work was identical before and after atenolol.It is concluded that the decrement in myocardial bloodflow and oxygen consumption effected by the drug could be attributed solely to the reduction in left ventricular work. No direct effect on coronary resistance could be identified. By reducing left ventricular work atenolol will be effective in the treatment of ischaemic heart disease. Since it increases left ventricular filling pressure it must be used with care in patients with latent heart failure.

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Section: Measurementsmentioning

confidence: 99%

Effect of atenolol (ICI 66 082) on coronary haemodynamics in man.

Simonsen¹

1977

Heart

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“…In one group (7 patients), a 7F double thermistor catheter with pacing electrodes (Wilton Webster laboratory) was passed through the left basilic vein and placed in a stable position in the coronary sinus. Earlier investigations (17) have demonstrated that changes in cardiac venous flow from different regions are proportional to one another. Because relative effects were studied, with the patient serving as his own control, the catheter position along the coronary sinus was of minor importance as long as the catheter position remained constant.…”

Section: Methodsmentioning

confidence: 96%

Effect of carbocromen induced coronary vasodilatation on myocardial metabolism in coronary artery disease

Kjekshus

Simonsen

Bøhmer

1978

Clinical Cardiology

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Myocardial metabolism was studied during coronary vasodilatation by carbocromen during atrial pacing in patients with coronary arteriosclerotic disease. Coronary sinus flow was measured by the continuous infusion thermodilution technique. Carbocromen increased myocardial flow by the same amount at rest and during pacing-induced tachycardia. The administration of carbocromen did not interfere with myocardial oxygen consumption, free fatty acid (FFA) uptake, pulmonary or systemic hemodynamics. Atrial pacing above the anginal threshold increased lactate and hypoxanthine excretion to the coronary sinus, but to a greater extent during carbocromen treatment. Thus, carbocromen is a specific coronary vasodilator acting independently of pacing induced vasodilatation. Metabolic data indicate a small but unfavourable effect on ischemic metabolism which might be due to a "coronary steal".

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“…The catheters were flushed with saline solu tion without heparin. Cardiac venous flow (CVF) was measured by the constant infusion thermodilution method [8] which has been found to be a reproducible and reliable method [9], Aortic pressure was measured by a Siemens Elenia transducer 746 and recorded on a Siemens Elema Mingograph 82. An average of 10 con secutive beats was used.…”

Section: Methodsmentioning

confidence: 99%

Reproducibility of Ischaemic Lactate Metabolism during Atrial Pacing in Man

Ihlen¹,

Simonsen²,

Vatne³

1983

Cardiology

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The reproducibility of myocardial ischaemia provoked by atrial pacing was studied in two groups of patients. The heart rate was slowly increased (10 beats per fourth min) until angina in group A, and quickly increased (10 beats per 20 s) in group B. Cardiac venous flow was measured by thermodilution and blood was sampled for metabolic studies at rest and during the maximum obtained heart rate and repeated after 20 min of rest. Ischaemia was defined as a reduction in myocardial lactate extraction ratio by 50% and to a ratio lower than 0.15. Lactate metabolism changed from production (-0.06 ± 0.05) during the first pacing to extraction (0.05 ± 0.05) during the second in group A (p < 0.02). Lactate metabolism was quite reproducible in group B. All the other metabolic and haemodynamic parameters were unchanged in both groups. We conclude that the duration of atrial pacing is important for the reproducibility of pacing-induced myocardial ischaemia.

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Aspects of Cardiac Venous Flow Measured by the Continuous Infusion Thermodilution Technique

Cited by 18 publications

References 13 publications

Effect of atenolol (ICI 66 082) on coronary haemodynamics in man.

Effect of atenolol (ICI 66 082) on coronary haemodynamics in man.

Effect of carbocromen induced coronary vasodilatation on myocardial metabolism in coronary artery disease

Reproducibility of Ischaemic Lactate Metabolism during Atrial Pacing in Man

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