Aspects of cognitive assessments and spectroscopic magnetic resonance imaging in people with chronic hepatitis C: a systematic review

Carvalho, Tatiana Lins; Lima, Alessandra Cintia Mertens Brainer de Queiroz; Araújo, Noemi Salazar de; Fernandes, Matheus Santos de Sousa; Lira, Gabriela Barza; Melo, Marcela Maria Medeiros de; Vasconcelos, Luydson Richardson Silva; Moura, Patrícia; Correia, Carolina da Cunha

doi:10.1080/13548506.2022.2029915

Cited by 1 publication

(1 citation statement)

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“…In HCV, changes in neurometabolite levels contrast with ndings in cirrhosis and demonstrate higher than control levels of Cho/tCr and mI/tCr in basal ganglia and white matter regions (Thames et al 2015;Forton et al 2001;Forton et al 2002;McAndrews et al 2005;Forton et al 2008;Bokemeyer et al 2010;Grover et al 2012;Bladowska et al 2013). Indeed, recent reviews conclude that in addition to high Cho and mI, tCr levels are also higher in those with than those without HCV infection (Oriolo et al 2018;Carvalho et al 2022).…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Serum biomarkers of liver fibrosis identify changes in striatal metabolite levels

Zahr

Sullivan

Pfefferbaum

2023

Preprint

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1H-magnetic resonance spectroscopy (MRS) conducted in cirrhosis shows consistent CNS changes such as high levels of the combined resonances (Glx) of glutamate (Glu) + glutamine (Gln) and low levels of choline-containing compounds (Cho) and myo-Inositol (mI) relative to total creatine (tCr). Studies of hepatitis C virus (HCV) infection, however, note higher than control levels of tCr, Cho, and mI. Here, serum markers of liver fibrosis were evaluated to determine whether they would discriminate neurometabolites in striatum, cerebellum, and pons. An aspartate aminotransferase to platelet ratio index (APRI)>0.7 identified liver fibrosis in 9.0% (n=13) of the cohort; a fibrosis score (FIB4)>1.5 identified liver fibrosis in 32.4% (n=34) of the population. Those with APRI>0.7 had higher levels of striatal tCr (p=.001) and Cho (p=.0003). Similarly, those with FIB>1.5 had higher levels of striatal Cho (p=.01). A multiple regression including the variables APRI>0.7 and HCV explained 16.5% of the variance in striatal Cho and was driven by the APRI. Likewise, the FIB4 relative to HCV explained more of the variance in striatal Cho. Higher striatal Cho levels showed a positive relationship with pallidal signal intensities (r=.18, p=.04). Further, higher pallidal T1-signals were associated with greater standing balance instability with eyes closed (r=-.22, p=.008). Together, these results suggest that elevations in striatal Cho and basal ganglia T1-signal intensities are related to presence of liver fibrosis with functional consequences.

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