Aspects of Collagen Mineralization in Hard Tissue Formation

Wiesmann, Hans‐Peter; Meyer, Ulrich; Plate, Ulrich; Höhling, H. J.

doi:10.1016/s0074-7696(04)42003-8

Cited by 110 publications

(95 citation statements)

References 110 publications

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“…Recently, Wiesmann et al (2005) have reviewed the process of collagen mineralization more in detail in different mineralized tissues, with special emphasis on the structural relationship between developing crystallites and collagen.…”

Section: The Mineralization Of Acellular Cementummentioning

confidence: 99%

Mineralization process during acellular cementogenesis in rat molars: a histochemical and immunohistochemical study using fresh-frozen sections

Yamamoto

Domon

Takahashi

et al. 2006

Histochem Cell Biol

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This study was designed to detect tissue non-specific alkaline phosphatase (TNSALP) by Azo-dye staining, calcium by glyoxal bis(2-hydroxyanil) (GBHA) staining, bone sialoprotein (BSP) and osteopontin (OPN) by immunoperoxidase staining in developing rat molars, and also to discuss the mineralization process during acellular cementogenesis. To restrain a reduction in histochemical and immunohistochemical reactions, fresh-frozen undemineralized sections were prepared. Where the epithelial sheath was intact, TNSALP reaction was observed in the dental follicle, but not in the epithelial sheath. With the onset of dentin mineralization, the BSP-and OPN-immunoreactive, initial cementum layer appeared. At this point cementoblasts had shown intense TNSALP reaction and GBHA reactive particles (=calcium-GBHA complex) appeared on the root surface. With further development, the reaction of TNSALP and GBHA became weak on the root surface. Previous studies have shown that the initial cementum is fibril-poor and that matrix vesicles and calciferous spherules appear on the root surface only during the initial cementogenesis. The findings mentioned above suggest that: During the initial cementogenesis cementoblasts release matrix vesicles which result in calciferous spherules, corresponding to the GBHA reactive particles. The calciferous spherules trigger the mineralization of the initial cementum. After principal fiber attachment mineralization advances along collagen fibrils without matrix vesicles.

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Section: The Mineralization Of Acellular Cementummentioning

confidence: 99%

Mineralization process during acellular cementogenesis in rat molars: a histochemical and immunohistochemical study using fresh-frozen sections

Yamamoto

Domon

Takahashi

et al. 2006

Histochem Cell Biol

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“…They have the ability to fill a space continuously [36], with no breaks. The molecular mechanism for the triggering the biomineralization process is encoded and performed within an organism with the help of special proteins [37][38][39][40][41][42], enzymes [43], sulfated mucopolysaccharide [44], extracellular matrix vesicles [45] and energetic control [46]. It is possible to present the process of biomineralization by changing the organic matrix [47].…”

Section: Concerning Protein Chain Synthesis On Apatite and Carbonate-mentioning

confidence: 99%

The Possibility of the Formation of Protocells and Their Structural Components on the Basis of the Apatite Matrix and Cocrystallizing Minerals

Kostetsky

2005

J Biol Phys

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Abstract. This paper presents the author's theory on the possibility of simultaneous hard-phase synthesis of various organic molecules from gas-phase elements on the basis of the apatite matrix and cocrystallizing minerals (carbonate-apatite, calcite, mica). These molecules and their ensembles gave rise to living systems and protocells of the pro-and eukaryotic types. Synthesis might have occurred through gradual substitution of the mineral matrix by crystal organic matter. The structure and size of the molecules synthesized were determined by the structure, physical parameters, and arrangement of organizing centers in the crystal lattice. Apatite phosphates were embedded in a synthesized nucleic helix and their size and purine-pyrimidine complementarity were determined. Apatite and cocrystallizing minerals were seen to be involved in the synthesis of four basic classes of cell components: apatite-DNA and nucleoproteide complexes; carbonate-apatite-enzymes, other proteins involved in DNA replication, all RNA types and their complexes with the specific proteins and enzymes of transcription and translation; calcite-cytoskeletal proteins; and mica-membrane lipids and proteins. The evidence supporting this theory is presented. A possible mechanism to account for the transition from crystal through organo-mineral crystal to liquid crystal (protocell) and a model of the occurrence of the matrix mechanism of transcription and translation are proposed. Some principal problems in the biochemistry and molecular biology of the origin of life on the Earth are discussed.Key words: origin of life, protocells, minerals, organo-mineral crystal, liquid crystal, molecular evolution, matrix mechanism Abbreviations: NA, nucleic acid; NP, nucleoprotein; EC, elementary cell; Ap-DNA, apatite DNA (hypothetical model based on the apatite crystal structure)

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“…The bulk of the dentin comprises intertubular dentin (ITD), whose organic content is approximately three times higher than in PTD [14]. In ITD, collagen assembles a solid framework with fibrils arranged into incremental planes, oriented preferentially in layers perpendicular to DT and parallel to the long axis of the root [9,[19][20][21][22]. The major role of interwoven collagen fibrils is to control deposition and orientation of HA crystals [20].…”

Section: Introductionmentioning

confidence: 99%

Animal and human dentin microstructure and elemental composition

et al. 2014

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AbstractAnimal teeth are a common model in studies on dentin adhesive materials. The aim of this study was to compare microstructural parameters (density and diameter of dentinal tubules (DT), peritubular dentin (PTD) thickness, PTD and intertubular dentin (ITD) surface area) and chemical characteristics of canine, porcine, equine, and human root dentin. The middle layers of dentin were harvested just below a cemento-enamel junction from incisors and investigated by means of scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDXS). SEM evaluation of the specimens revealed, that porcine dentin shared most similarities with human dentin. When comparing the density of DTs, canine dentin was also found to be similar to human dentin. Elemental composition of the root dentin did not differ significantly in porcine, equine and human dentin, but in canine dentin higher magnesium value in PTD compared to ITD was found. It is known that microstructural and chemical characteristics affect the strength of the adhesive bonds created among restorative materials and dentin. According to the results of this study, porcine dentin seems to be the most appropriate model to study dental materials to be used in human restorative dentistry.

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Aspects of Collagen Mineralization in Hard Tissue Formation

Cited by 110 publications

References 110 publications

Mineralization process during acellular cementogenesis in rat molars: a histochemical and immunohistochemical study using fresh-frozen sections

Mineralization process during acellular cementogenesis in rat molars: a histochemical and immunohistochemical study using fresh-frozen sections

The Possibility of the Formation of Protocells and Their Structural Components on the Basis of the Apatite Matrix and Cocrystallizing Minerals

Animal and human dentin microstructure and elemental composition

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