Aspects of medical history and exocrine carcinoma of the pancreas: A population‐based case‐control study in The Netherlands

Abstract

During 1984-88 a population-based case-control study was carried out in The Netherlands, in collaboration with the International Agency for Research on Cancer, to examine the possible relationship between aspects of medical history and exocrine pancreatic carcinoma in 176 cases and 487 controls. About 58% of patients were interviewed directly. We observed an inverse relationship between medical treatment for allergy-related conditions and the development of pancreatic cancer (30 cases vs. 130 controls, OR 0.57, 95% CI 0.36 to 0.90). A history of gallbladder problems, gallstones, cholecystectomy, stomach or duodenal ulcer, pancreatitis, appendicitis, diabetes or tonsillectomy was not related to risk. In direct responses, compared with once daily, a positive relationship was seen for stool frequency, 10 years ago, of less than once daily (18 cases vs. 40 controls, OR 2.10, 95% CI 1.09 to 4.04). In men, diabetes treated with insulin and diagnosed more than 1 year previously was significantly and positively related to risk (5 cases vs. 1 control, OR 11.66, 95% 1.28 to 105.95). In brief, the results of the present study suggest that a history of allergy-related conditions may protect, whereas a past stool frequency of less than once daily may enhance the risk of cancer of the pancreas. Other elements of the medical history were not consistently related to risk.

Early Detection of Pancreatic Cancer following the Diagnosis of Chronic Pancreatitis

“…In addition, a diagnosis of non-insulin-dependent diabetes mellitus at the time of (mis)diagnosis of CP was more frequent in the CP group without PCr. This finding is consistent with results of recent reports [22, 23]. …”

Pancreatic cancer and medical history in a population-based case–control study in the San Francisco Bay Area, California

“…Prior epidemiologic studies that have examined history of peptic ulcer disease and pancreatic cancer have found no association between the two [10,25,26,36,[54][55][56]. Epidemiologic data are mixed regarding the association between peptic ulcer surgery and pancreatic cancer.…”

“…Specifically, the increased risk was seen only among participants in whom cholelithiasis was diagnosed within a year of the time of diagnosis or interview for the controls. Epidemiologic studies that have investigated the potential association between cholelithiasis/cholecystectomy and risk of pancreatic cancer have produced inconsistent results [8,[25][26][27][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52]. Several early case-control studies showed no association between gallbladder disease and pancreatic cancer [25,26,49].…”

“…Pre-existing diabetes mellitus has been studied extensively as a potential risk factor for pancreatic cancer with inconsistent results [6,8,12,[24][25][26][27]. One literature review and metaanalysis suggested that individuals with longstanding diabetes (i.e.…”

Cholecystectomy and risk of pancreatic cancer: a meta-analysis of observational studies

“…A total of 8 cohort studies [9,10,13,[16][17][18]27, 33] and 10 case-control studies [11,12,14,15,26,[34][35][36][37][38] were included in the meta-analysis (Tables 1 and 2). These 18 studies, reporting a total of 12,129 incident cases of PaC, were conducted between 1950 and 2004.…”