The n-partite information (nI) is formulated as a measure of multi-partite entanglement. Field theory computation revealed that the sign of nI is indefinite for n ≥ 3, while holographic studies conjectured a sign property that holographic nI is non-negative/non-positive for even/odd n, with tripartite information (TI, n = 3) proved. We investigate the aspects of nI with holographic duality in hyperscaling violating geometry. We confirm the conjectured sign property for strips of equal length with equal separation distance, and disprove this conjecture for n > 3 with general configurations. Therefore, nI in field theories and holography exhibits compatibility except for n = 3. We also discuss other properties of holographic nI with analytic computation: the monotonicity, linearity, relation to hyperscaling violating parameters, temperature and UV cutoff effects, and the physical implications. It is doubtful that nI is an effective measure of entanglement considering the indefinite sign, non-monotonicity, and quasi-linearity of its holographic dual. In this respect, we propose constraints on the multi-partite entanglement measures.