Aspects of neonatal metabolism of trace metals

Pj, Aggett

doi:10.1111/j.1651-2227.1994.tb13366.x

Cited by 19 publications

(12 citation statements)

References 55 publications

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“…The mobilisation of Cu in mothers during pregnancy leads to 2-fold higher maternal serum Cu concentrations compared to healthy adults. Umbilical cord sera values amount only 20% of that of the mothers, providing 51 mg Cuakg body weight daily to be accumulated by the human foetus (Aggett, 1994). The high correlation coef®-cients for concentrations of the alkaline elements Li and Cs in umbilical cord and maternal sera, which have Na and K as neighbors in the periodic table of the elements, suggest that Li and Cs follow concentration gradients, so does Sr.…”

Section: Discussionmentioning

confidence: 99%

Trace element transfer from the mother to the newborn — investigations on triplets of colostrum, maternal and umbilical cord sera

1999

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Objective: To investigate the trace element transfer from the mother to the newborn. Design: The concentrations of the eight essential elements calcium (Ca), cobalt (Co), copper (Cu), magnesium (Mg), manganese (Mn), molybdenum (Mo), tin (Sn), and zinc (Zn), and of the non-essential and toxic elements barium (Ba), beryllium (Be), bismuth (Bi), cadmium (Cd), cesium (Cs), lanthanum (La), lithium (Li), lead (Pb), rubidium (Rb), antimony (Sb), strontium (Sr), and thallium (Tl) were determined in umbilical cord (n 29) and corresponding maternal sera (n 29) as well as in colostrum (n 27). Results: Umbilical cord serum concentrations of Ca, Mn, and Zn were 120%, 150%, and 148% of the maternal value, respectively. Maternal sera had twice the Cu concentrations found in healthy adults and ®ve-times higher Cu than umbilical cord sera. Concentration ratios colostrumamaternal serum and colostrumaumbilical cord serum were approximately one for Co, 1.4 for Mg, two for Ca, Mn, and Sn, ®ve for Cu (maternal serum), eight for Mo, and ten for Zn. Concentrations of the toxic elements Cd and Pb decreased in the order colostrum (Pb 2.6 mgaL; Cd 0.6 mgaL), maternal sera (0.8 mgaL; 0.3 mgaL), umbilical cord sera (0.4 mgaL; 0.2 mgaL). Maternal serum Ba and Rb was 182% and 66% of the umbilical cord value. For Sr and Li, an almost perfect correlation between umbilical cord and maternal sera was found. For Ba, Co, Cu, Mn, Zn none, and for Ca, Cs, Mn, Mo, Rb only weak positive correlations between these two compartments could be established. Conclusions:The results of this study indicate that an active transport mechanism for the transport of Ca, Mn, Rb, and Zn from the mother to the newborn exists, whereas Cs, Li, and Sr follow concentration gradients. As regards Cu, the placenta showed to have a blocking effect on the transfer from the mother to the baby.

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Section: Discussionmentioning

confidence: 99%

Trace element transfer from the mother to the newborn — investigations on triplets of colostrum, maternal and umbilical cord sera

1999

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“…About 75 mg of elemental Cu is needed daily to meet the requirements of pregnancy and the calculated daily Cu accumulation by a fetus is 51 mg/kg body weight/24 h and at term (Gathwala and Vadav, 2002). So, the relatively low serum Cu concentrations, which were evaluated in the Albanian mothers, in whom Cu intake was very poor, as indicated from their dietetic diaries, could be responsible for the low Cu concentrations of their infants (Vuori et al, 1980;Agget, 1994;Thomas, 2001). Albanian immigrant mothers live under difficult low socioeconomic conditions.…”

Section: Discussionmentioning

confidence: 99%

“…The essential nature of micronutrients has been recognized through the identification of clinical conditions associated with severe deficiencies of particular vitamins or minerals, and through subsequent animal experiments (Agget, 1994;King, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…During this time, inadequate stores or intake of vitamins or minerals, referred to collectively as micronutrients, can have adverse effects on the mother, such as anemia, hypertension, complications of labor or even death. Furthermore, the fetus can be affected, resulting in a stillbirth, preterm delivery, intrauterine growth retardation, congenital malformations, reduced immunocompetence and abnormal organ developments (Agget, 1994;King, 2000).…”

Section: Introductionmentioning

confidence: 99%

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Maternal – neonatal serum selenium and copper levels in Greeks and Albanians

Schulpis

Karakonstantakis

Gavrili³

et al. 2004

Eur J Clin Nutr

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Aim: To evaluate selenium (Se) and copper (Cu) concentrations in Greek and Albanian immigrant mothers and in the cord blood of their newborns. Subjects and methods: From 1118 Greek and 820 Albanian mothers and from the cord blood of their neonates blood was obtained for Se and Cu measurement. Se and Cu concentrations were determined in sera with graphite furnace atomic absorption spectroscopy (GFAAAS) and atomic absorption spectrometry, respectively. In all, 30 days' nutrient intakes were evaluated in both groups. Results: Animal protein, Se and Cu intakes were poor in the Albanians vs the Greeks (Po0.001). Se concentrations in the Greek mothers (68.378.5 mg/l) and in their newborns (37.0278.9 mg/l) were found higher as compared with those in Albanian mothers (37.479.9 mg/l) and in their newborns (34.379.1 mg/l) (Po0.001). Cu levels were also found higher (Po0.001) in the Greek mothers (16877353 mg/l) and in their neonates (449787 mg/l) compared with those in the Albanian mothers (9597318 mg/l) and in their newborns (229767 mg/l). Additionally, 31.5% of neonates born to Albanian women with Se concentrations less than 28 mg/l had higher Se levels (Po0.01) than their mothers. Conclusions: The low Se and Cu levels evaluated in the Albanian mothers and their newborns could be related to their poor animal protein intake which could be the consequence of their low socioeconomic status. As an effective preventive measure, accurate dietetic strategies to assess the requirements of pregnant immigrant women for trace elements may be planned in Greece.

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“…Cases of Zn deficiency were reported in neonates born at T and PT (Aggett, 1994), mainly in PT. It is known that the accumulation of Zn in the colostrum of mothers of PT new-borns were lower when compared with mothers whose infants were born were at T, taking into consideration the same lactation period: this could suggest a risk of Zn deficiency for PT.…”

Section: Discussionmentioning

confidence: 99%

Characterization of iron, copper and zinc levels in the colostrum of mothers of term and pre-term infants before and after pasteurization

Costa

Carmo²,

Saunders³

et al. 2003

International Journal of Food Sciences and Nutrition

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Pasteurization is a thermal treatment applied to the milk used in human milk banks so as to provoke the thermic inactivation of pathogenic micro-organisms, with the aim of avoiding contamination of milk that will be offered to new-born infants in clinical conditions very often demanding special care. The literature has very little data available relating to the effect of pasteurization on the concentration of oligo-elements in human milk. The objective of this study was to evaluate the effect of pasteurization on the concentrations of iron (Fe), copper (Cu) and zinc (Zn) in the colostrum of mothers of pre-term (PT) and term (T) infants. Samples were collected from the day of birth to the seventh day after birth. The oligo-elements were analyzed using the total reflection Xray fluorescence technique with synchrotron radiation. The following results of Fe, Cu and Zn (means9/SD) were obtained for the PT and T colostrum samples, non-pasteurized and pasteurized, respectively:

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Aspects of neonatal metabolism of trace metals

Cited by 19 publications

References 55 publications

Trace element transfer from the mother to the newborn — investigations on triplets of colostrum, maternal and umbilical cord sera

Trace element transfer from the mother to the newborn — investigations on triplets of colostrum, maternal and umbilical cord sera

Maternal – neonatal serum selenium and copper levels in Greeks and Albanians

Characterization of iron, copper and zinc levels in the colostrum of mothers of term and pre-term infants before and after pasteurization

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