Aspects of sleep in centenarians

Spadafora, F.L.; A, Curti; Teti, R.; Belmonte, M.; Castagna, Alberto; Mercurio, Marco; Infusino, P.; Tavernese, G.; Iannazzo, P.S.; Iorio, Cesare Di; Mattace, R

doi:10.1016/0167-4943(96)86975-5

Cited by 3 publications

(3 citation statements)

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“…Other clinical studies on sleep quality among centenarians have reported various results, ranging from reports of overall good sleep ( 42 ) to reports of sleeping problems among the majority of the participants ( 43 ). The majority of centenarians in our study reported sleeping problems at enrollment, but had a similar prevalence of sleep problems at age 70 compared with offspring and controls.…”

Section: Discussionmentioning

confidence: 99%

Association between Sleep Patterns and Health in Families with Exceptional Longevity

et al. 2017

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BackgroundSleep patterns such as longer sleep duration or napping are associated with poor health outcomes. Although centenarians and their offspring demonstrate a delayed onset of age-related diseases, it is not known whether they have healthier sleep patterns or are protected against the negative effects of sleep disturbances.MethodsData on sleep patterns and health history were collected from Ashkenazi Jewish subjects of the Longevity Genes Project using standardized questionnaires. Participants included individuals with exceptional longevity (centenarians) with preserved cognition (n = 348, median age 97 years), their offspring (n = 513, median age 69 years), and controls (n = 199) age-matched to the offspring. Centenarians reported on their sleep patterns at age 70, while the offspring and controls on their current sleep patterns. Biochemical parameters were measured at baseline. Models were adjusted for age, sex, BMI, and use of sleep medication.ResultsThe offspring and controls reported similar sleep patterns, with 33% sleeping ≥8 h and 17% napping in each group. At age 70, centenarians were more likely to have slept ≥8 h (55%) and to have napped (28%) compared with offspring and controls, p < 0.01. Among centenarians, no association was noted between sleep patterns and health outcomes. Sleeping for ≥8 h was associated with lower high-density lipoprotein cholesterol levels in the offspring and controls, and with insulin resistance in the offspring, but not with diabetes. Napping was associated with insulin resistance among the controls (p < 0.01), but not the offspring. Controls, but not offspring, who napped were 2.79 times more likely to have one or more of the following diseases: hypertension, myocardial infarction, stroke, or diabetes (OR 2.79, 95% CI 1.08–7.21, p = 0.04).ConclusionDespite being more likely to exhibit risky sleep patterns at age 70 compared with the offspring and controls, the centenarians were protected from age-related morbidities. The offspring of centenarians did exhibit metabolic disturbances in association with less healthy sleep patterns; however, unlike the controls, they were much less likely to manifest age-related diseases. This suggests that offspring may have inherited resilience genotypes from their centenarian parents that protect them against the harmful effects of sleep disturbances.

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Section: Discussionmentioning

confidence: 99%

Association between Sleep Patterns and Health in Families with Exceptional Longevity

et al. 2017

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“…Middle-aged (20 month) BRASTO mice also exhibit improved healthspan parameters when compared to their aged matched controls; they are more physically active, have higher core body temperature, consume more oxygen, and have more non-REM sleep. Similar traits are often correlated with increased quality of life in elderly humans ( Rea et al, 2015 ; Spadafora et al, 1996 ; Simonsick et al, 2016 ). While the causative mechanisms behind the improved health and longevity of BRASTO mice are not fully characterized, they show an increase in skeletal muscle mitochondria and mitochondrial functional gene expression in addition to higher mRNA expression of markers of neuronal activity in hypothalamic neurons.…”

Section: Mammalsmentioning

confidence: 97%

Cell non-autonomous regulation of health and longevity

Dean

Pletcher

et al. 2020

eLife

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As the demographics of the modern world skew older, understanding and mitigating the effects of aging is increasingly important within biomedical research. Recent studies in model organisms demonstrate that the aging process is frequently modified by an organism’s ability to perceive and respond to changes in its environment. Many well-studied pathways that influence aging involve sensory cells, frequently neurons, that signal to peripheral tissues and promote survival during the presence of stress. Importantly, this activation of stress response pathways is often sufficient to improve health and longevity even in the absence of stress. Here, we review the current landscape of research highlighting the importance of cell non-autonomous signaling in modulating aging from C. elegans to mammals. We also discuss emerging concepts including retrograde signaling, approaches to mapping these networks, and development of potential therapeutics.

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“…In centenarians the quality and the quantity of a major circadian clock such as sleep, appear to be well preserved. It has been reported that 48 Italian (Calabrian) centenarians go to sleep early in the evening, have no problems in falling asleep, wake up early in the morning, take a nap in the afternoon and do not take pills before going to bed (119). Another study on a relatively large group of 180 centenarians from Rome demonstrated the existence of a positive correlation between sleep quality, survival and successful aging (123).…”

Section: Do Nutritional Habits Impinge Upon the Maintenance Of Circadian Rhythms In Centenarians?mentioning

confidence: 99%

Nutrition and Inflammation: Are Centenarians Similar to Individuals on Calorie-Restricted Diets?

2018

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Individuals capable of reaching the extreme limit of human life such as centenarians are characterized by an exceptionally healthy phenotype-that is, a low number of diseases, low blood pressure, optimal metabolic and endocrine parameters, and increased diversity in the gut microbiota-and they are epigenetically younger than their chronological age. We present data suggesting that such a remarkable phenotype is largely similar to that found in adults following a calorie-restricted diet. Interviews with centenarians and historical data on the nutritional and lifestyle habits of Italians during the twentieth century suggest that as children and into adulthood, centenarians lived in an environment that was nonobesogenic, but at the same time the environment did not produce malnutrition. Centenarians appear to be creatures of habit, and we argue that their habit of eating meals at the same time each day favored the maintenance of circadian rhythms, including their sleep cycle. Finally, we argue that centenarians' chronic inflammatory status, which we dubbed inflammaging, is peculiar, likely adaptive, and less detrimental than in younger people.

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Aspects of sleep in centenarians

Cited by 3 publications

References 1 publication

Association between Sleep Patterns and Health in Families with Exceptional Longevity

Association between Sleep Patterns and Health in Families with Exceptional Longevity

Cell non-autonomous regulation of health and longevity

Nutrition and Inflammation: Are Centenarians Similar to Individuals on Calorie-Restricted Diets?

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