“…The endothelin system consists of endothelin-1 (EDN-1), endothelin-2 (EDN-2), endothelin-3 (EDN-3), the G-proteincoupled receptors, endothelin receptor type A (EDNRA) and endothelin receptor type B (EDNRB), endothelin converting enzyme 1 (ECE1), and endothelin converting enzyme 2 (ECE2) (Wang et al, 2013;Mahdi et al, 2014). Endothelin-1 has an enhancing effect on cancer cell proliferation, survival, invasion, and migration; it also has an effect on cancer stroma cells such as fibroblasts [proliferation, migration, contraction, extracellular matrix (ECM) remodeling], macrophages (chemo-attraction, ECM remodeling), and endothelial cells (proliferation, angiogenesis) (Bhalla et al, 2009).…”