Aspects of the interactions between indomethacin and nicotinamide in solid dispersions

Improving the Chemical Stability of Amorphous Solid Dispersion with Cocrystal Technique by Hot Melt Extrusion

“…This may be attributed to the hydrogen bonding between CBZ and NIC which facilitates the formation of CBZ-NIC cocrystal. Similar spectral patterns were observed in indomethacin-NIC melt (28) and ibuprofen-NIC complex (29).…”

Comparison of pharmaceutical formulations: ATR-FTIR spectroscopic imaging to study drug-carrier interactions

“…A range of analytical techniques, including FTIR spectroscopy and UV spectroscopy, were used to assess the dissolution of indomethacin. Bogdanova et al (1998) reported that although there was an increase in the dissolution of drug for some indomethacin/nicotinamide formulations, for those with a molar ratio above 1:1 (M/M) there was no improvement in the amount of drugs dissolved compared to those measured for pure amorphous indomethacin samples.…”

“…The composition of the different tablets studied is shown in Table 2. Nicotinamide forms hydrogen bonded complexes with indomethacin, resulting in potential physicochemical interactions between the readily and poorly soluble materials (Bogdanova et al, 1998;Maruyoshi et al, 2012). Provided that these intermolecular interactions are maintained during the dissolution process, the more readily soluble drug acts as a carrier and thus increases the release of the poorly water-soluble drug into the surrounding solution.…”

“…A robust and reliable approach is needed to reveal how the two components will interact and influence the drug release. In some cases, interaction between the drugs may be undesirable (Shende et al, 2013); conversely, dissolution and release of poorly water-soluble drugs can be improved by interactions with a more soluble drug candidate (Bogdanova et al, 1998). The inherent chemical specificity of ATR-FTIR spectroscopic imaging, together with UV detection has demonstrated the potential of this combinational setup to propose valuable mechanistic insight about such systems.…”

“…Ionic interactions and molecular aggregation increased solubilisation of indomethacin in these samples, but the interest for this specific investigation is the study of solid tablet compacts. Binary systems of indomethacin and nicotinamide in solid dispersions have also been studied with respect to improving the release of the drug (Bogdanova et al, 1998). A range of analytical techniques, including FTIR spectroscopy and UV spectroscopy, were used to assess the dissolution of indomethacin.…”