Asperfuranone from <i>Aspergillus nidulans</i> Inhibits Proliferation of Human Non‐Small Cell Lung Cancer A549 Cells via Blocking Cell Cycle Progression and Inducing Apoptosis

Wang, Clay C. C.; Chiang, Yi‐Ming; Praseuth, Mike B.; Kuo, Po‐Lin; Liang, Hsin-Lin; Hsu, Ya‐Ling

doi:10.1111/j.1742-7843.2010.00545.x

Cited by 23 publications

(14 citation statements)

References 27 publications

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“…Dihydroxy-fumitremorgin C Antitumoural Coastal sediments [190] Penicillium paneum Penipacids A and Penipacids E Antitumoural Deep-sea sediments [191] Aspergillus sulphureus KMM 4640 Decumbenone C Antitumoural Marine sediments [192] Penicillium sp. PR19N-1 Sesquiterpene, Eremofortine C Antitumoural Antarctic deep-sea [195] Aspergillus nidulans Asperfuranone Antitumoural Marine [196] Aspergillus sp.…”

Section: Fungi In Dhabs As Potential Producers Of Biomolecules For Phmentioning

confidence: 99%

Marine Fungi: Biotechnological Perspectives from Deep-Hypersaline Anoxic Basins

et al. 2019

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Deep-sea hypersaline anoxic basins (DHABs) are one of the most hostile environments on Earth. Even though DHABs have hypersaline conditions, anoxia and high hydrostatic pressure, they host incredible microbial biodiversity. Among eukaryotes inhabiting these systems, recent studies demonstrated that fungi are a quantitatively relevant component. Here, fungi can benefit from the accumulation of large amounts of organic material. Marine fungi are also known to produce bioactive molecules. In particular, halophilic and halotolerant fungi are a reservoir of enzymes and secondary metabolites with valuable applications in industrial, pharmaceutical, and environmental biotechnology. Here we report that among the fungal taxa identified from the Mediterranean and Red Sea DHABs, halotolerant halophilic species belonging to the genera Aspergillus and Penicillium can be used or screened for enzymes and bioactive molecules. Fungi living in DHABs can extend our knowledge about the limits of life, and the discovery of new species and molecules from these environments can have high biotechnological potential.

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Section: Fungi In Dhabs As Potential Producers Of Biomolecules For Phmentioning

confidence: 99%

Marine Fungi: Biotechnological Perspectives from Deep-Hypersaline Anoxic Basins

et al. 2019

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“…14f), 26, 148 asperfuranone (Fig. 14g), 137, 149 sclerotiorin, 150–152 azanigerones, 153 and mitorubrins (Fig. 14i).…”

Section: Nonreducing Iterative Polyketide Synthase Natural Productsunclassified

Natural products from thioester reductase containing biosynthetic pathways

et al. 2018

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Thioester reductase domains catalyze two- and four-electron reductions to release natural products following assembly on nonribosomal peptide synthetases, polyketide synthases, and their hybrid biosynthetic complexes. This reductive off-loading of a natural product yields an aldehyde or alcohol, can initiate the formation of a macrocyclic imine, and contributes to important intermediates in a variety of biosyntheses, including those for polyketide alkaloids and pyrrolobenzodiazepines. Compounds that arise from reductase-terminated biosynthetic gene clusters are often reactive and exhibit biological activity. Biomedically important examples include the cancer therapeutic Yondelis (ecteinascidin 743), peptide aldehydes that inspired the first therapeutic proteasome inhibitor bortezomib, and numerous synthetic derivatives and antibody drug conjugates of the pyrrolobenzodiazepines. Recent advances in microbial genomics, metabolomics, bioinformatics, and reactivity-based labeling have facilitated the detection of these compounds for targeted isolation. Herein, we summarize known natural products arising from this important category, highlighting their occurrence in Nature, biosyntheses, biological activities, and the technologies used for their detection and identification. Additionally, we review publicly available genomic data to highlight the remaining potential for novel reductively tailored compounds and drug leads from microorganisms. This thorough retrospecive highlights various molecularfamilies with especially privileged bioactivity while illuminating challenges and prospects toward accelerating the discovery of new, high value natural products.

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“…Asperfuranone was later shown to possess bioactive properties as it inhibited proliferation of human non-small A549 cancer cells [90]. Investigating the loci containing putative PKS gene clusters, Chiang and co-workers [89] noticed that a NR-PKS gene (AN1034, afoE ) and a HR-PKS gene (AN1036, afoG ) were located close to each other on chromosome VIII.…”

Section: Asperfuranonementioning

confidence: 99%

Genetics of Polyketide Metabolism in Aspergillus nidulans

et al. 2012

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Secondary metabolites are small molecules that show large structural diversity and a broad range of bioactivities. Some metabolites are attractive as drugs or pigments while others act as harmful mycotoxins. Filamentous fungi have the capacity to produce a wide array of secondary metabolites including polyketides. The majority of genes required for production of these metabolites are mostly organized in gene clusters, which often are silent or barely expressed under laboratory conditions, making discovery and analysis difficult. Fortunately, the genome sequences of several filamentous fungi are publicly available, greatly facilitating the establishment of links between genes and metabolites. This review covers the attempts being made to trigger the activation of polyketide metabolism in the fungal model organism Aspergillus nidulans. Moreover, it will provide an overview of the pathways where ten polyketide synthase genes have been coupled to polyketide products. Therefore, the proposed biosynthesis of the following metabolites will be presented; naphthopyrone, sterigmatocystin, aspyridones, emericellamides, asperthecin, asperfuranone, monodictyphenone/emodin, orsellinic acid, and the austinols.

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Asperfuranone from Aspergillus nidulans Inhibits Proliferation of Human Non‐Small Cell Lung Cancer A549 Cells via Blocking Cell Cycle Progression and Inducing Apoptosis

Cited by 23 publications

References 27 publications

Marine Fungi: Biotechnological Perspectives from Deep-Hypersaline Anoxic Basins

Marine Fungi: Biotechnological Perspectives from Deep-Hypersaline Anoxic Basins

Natural products from thioester reductase containing biosynthetic pathways

Genetics of Polyketide Metabolism in Aspergillus nidulans

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