Aspergillosis in 25 Renal Transplant Patients: Epidemiology, Clinical Presentation, Diagnosis, and Management

Weiland, Derek; Ferguson, Ronald M.; Peterson, Paul; Snover, Dale C.; Simmons, R. L.; Najarían, John S.

doi:10.1016/s0022-5347(17)50653-9

Cited by 23 publications

(43 citation statements)

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“…Factors suspected to favor the development of invasive aspergillosis in renal transplant recipients include exposure to antilymphocyte globulin, history of bacterial sepsis or pneumonia (which perhaps exposes the patients to prolonged antibiotic usage), and CMV infection [1]. The characteristics of 50 % of patients reported by Weiland et al [1] included at least two of these factors.…”

Section: Discussionmentioning

confidence: 99%

“…The characteristics of 50 % of patients reported by Weiland et al [1] included at least two of these factors. Our patient, for whom all three of these risk factors were noted, might have been recognized as being at high-risk for aspergillosis.…”

Section: Discussionmentioning

confidence: 99%

“…Cases of invasive aspergillosis have been reported after transplantation of the liver [2][3][4][5][6], kidney [1,[7][8][9][10][11], and heart [12][13][14][15]. Aspergillosis was diagnosed in 9 % of adult liver transplant recipients who received immunosuppressive therapy consisting of administration of azathioprine, prednisone, and antilymphocyte globulin [2].…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, 6 % of adult liver transplant recipients treated with cyclosporine and prednisone developed aspergillosis [3,4] . All patients with aspergillosis from those three series of liver transplantations [2][3][4] [1,[7][8][9][10][11] has survived. Similar survival rates among heart transplant recipients and an occasional survivor of pulmonary disease have been reported, but none of such patients in whom the aspergillosis involved the CNS survived [12][13][14][15] .…”

Section: Discussionmentioning

confidence: 99%

“…The outcome of infections due to Aspergillus species in solid-organ transplant recipients has been poor. Various clinical patterns of illness have been identified as prognostic markers; involvement of the CNS is usually fatal [1]. We report herein a favorable outcome in the case of a 6-month-old liver transplant recipient ",ho developed aspergillosis of the eNS.…”

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confidence: 90%

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Aspergillosis of the CNS in a Pediatric Liver Transplant Recipient: Case Report and Review

Green¹,

Wald²,

Tzakis³

et al. 1991

Clinical Infectious Diseases

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 90%

See 3 more Smart Citations

Aspergillosis of the CNS in a Pediatric Liver Transplant Recipient: Case Report and Review

Green¹,

Wald²,

Tzakis³

et al. 1991

Clinical Infectious Diseases

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Aspergillosis of the central nervous system: Clinicopathological analysis of 17 patients

Walsh

Hier

Caplan

1985

Annals of Neurology

239

120

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The clinical, laboratory, and pathological features of aspergillosis of the central nervous system (CNS) were studied in a series of 17 autopsied patients. Two groups were defined. Group A consisted of 8 patients with diseases commonly associated with CNS aspergillosis: leukemia, lymphoma, aplastic anemia, and renal transplantation. Group B contained 9 patients with various illnesses not generally known to be associated with CNS aspergillosis. CNS aspergillosis was diagnosed and treated before death in only 1 patient. Patients in Group A received cytotoxic drugs, often had granulocytopenia, less commonly had focal neurological deficits, and seldom had seizures. Group B patients were not granulocytopenic, received no cytotoxic agents, underwent nontransplant surgery, and more frequently had focal neurological deficits. Eleven of the 17 patients (65%) had focal deficits, most of them hemiparesis. Meningeal signs were rare, but the cerebrospinal fluid was usually abnormal. The principal neuropathological process was Aspergillus invasion of blood vessels causing hemorrhagic infarction. Focal clinical deficits correlated neuroanatomically with Aspergillus lesions. In 2 patients, such lesions were detected by 99mTc-DTPA or cerebral angiography before computed tomographic scanning. The lungs were the usual portal of entry, but isolated CNS lesions occurred in 2 patients. CNS aspergillosis should be considered as a cause of new onset of focal neurological deficits in patients with illnesses that are more diverse than has generally been appreciated.

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Efficacy and safety of Amphotericin B Lipid Complex Injection (ABLC) in solid‐organ transplant recipients with invasive fungal infections

Linden

Williams

Chan

2000

Clinical Transplantation

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Aspergillosis in 25 Renal Transplant Patients: Epidemiology, Clinical Presentation, Diagnosis, and Management

Cited by 23 publications

References 0 publications

Aspergillosis of the CNS in a Pediatric Liver Transplant Recipient: Case Report and Review

Aspergillosis of the CNS in a Pediatric Liver Transplant Recipient: Case Report and Review

Aspergillosis of the central nervous system: Clinicopathological analysis of 17 patients

Efficacy and safety of Amphotericin B Lipid Complex Injection (ABLC) in solid‐organ transplant recipients with invasive fungal infections

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