Aspergillosis in Surgical Patients

Pasqualotto, Alessandro C.

doi:10.1007/978-90-481-2408-4_30

Cited by 5 publications

(13 citation statements)

References 146 publications

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“…Unlike Aspergillus endocarditis where large vegetations are easily seen in echocardiography, myocardial or pericardial aspergillosis are harder to detect [5]. Our patient had septic emboli to the brain, a frequent sequelae of endocarditis.…”

Section: Aspergillosismentioning

confidence: 90%

“…It may occur alone but often with endocarditis or pericarditis. It is often asymptomatic, although it can manifest as a conduction abnormality and is usually diagnosed during autopsy [5]. …”

Section: Aspergillosismentioning

confidence: 99%

“…Aspergillus pericarditis occurs in multisite infections and is seen in 17% of cardiac aspergillosis [5]. It presents as chest pain, hypotension, tamponade, or pericardial friction rub.…”

Section: Aspergillosismentioning

confidence: 99%

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AspergillusPericarditis with Tamponade in a Renal Transplant Patient

Biso

Lekkham

Climaco

2017

Case Reports in Cardiology

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Aspergillus pericarditis is a rare and life-threatening infection in immunosuppressed patients. It has nonspecific clinical manifestations that often mimic other disease entities especially in patients who have extensive comorbidities. Diagnosis is oftentimes delayed and rarely done antemortem. A high degree of suspicion in immunocompromised patients is necessary for evaluation and timely diagnosis. This is a case of Aspergillus pericarditis with cardiac tamponade in a renal transplant patient with liver cirrhosis. Two months after transplant, he developed decompensation of his cirrhosis from hepatitis C, acute cellular rejection, and Kluyvera bacteremia, followed by vancomycin-resistant Enterococcus faecium (VRE) bacteremia. Four months after transplant, the patient presented with lethargy and fluid overload. He subsequently developed shock and ventilator-dependent respiratory failure. An echocardiogram showed pericardial effusion with cardiac tamponade. He had emergent pericardiocentesis that showed purulent drainage. He was started on broad-spectrum antibiotics. Amphotericin B was initiated when the pericardial fluid grew mold that was later identified as Aspergillus fumigatus. The patient quickly decompensated and expired.

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Section: Aspergillosismentioning

confidence: 90%

Section: Aspergillosismentioning

confidence: 99%

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AspergillusPericarditis with Tamponade in a Renal Transplant Patient

Biso

Lekkham

Climaco

2017

Case Reports in Cardiology

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“…Aspergillus airborne organisms may be introduced into the body (ear, wound, skin) by an object or following a post-operative procedure; otomycosis may also be considered as a super-infection following a bacterial otitis [ 11 , 12 , 13 , 14 ].…”

Section: Source Of Infectionmentioning

confidence: 99%

Aspergillus Genus and Its Various Human Superficial and Cutaneous Features

Merad¹,

Derrar²,

Belmokhtar

et al. 2021

Pathogens

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Superficial and cutaneous aspergillosis is a rare fungal disease that is restricted to the outer layers of the skin, nails, and the outer auditory canal, infrequently invading the deeper tissue and viscera, particularly in immunocompromised patients. These mycoses are acquired through two main routes: direct traumatic inoculation or inhalation of airborne fungal spores into paranasal sinuses and lungs. Lesions are classified into three categories: otomycosis, onychomycosis, and cutaneous aspergillosis. Superficial and cutaneous aspergillosis occurs less frequently and therefore remains poorly characterized; it usually involves sites of superficial trauma—namely, at or near intravenous entry catheter site, at the point of traumatic inoculation (orthopaedic inoculation, ear-self-cleaning, schizophrenic ear self-injuries), at surgery incision, and at the site of contact with occlusive dressings, especially in burn patients. Onychomycosis and otomycosis are more seen in immunocompetent patients, while cutaneous aspergillosis is widely described among the immunocompromised individuals. This paper is a review of related literature.

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“…For instance, negative results are commonly obtained for the detection of GM in sera of allergic bronchopulmonary aspergillosis. Reviews on diagnosis of aspergillosis have been published [ 108 , 109 , 110 ]. Apparently, this is the only commercialized test based on detection of Gal f .…”

Section: Immunologic Detection Of Gal F -Containinmentioning

confidence: 99%

Galactofuranose Antigens, a Target for Diagnosis of Fungal Infections in Humans

2017

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The use of biomarkers for the detection of fungal infections is of interest to complement histopathological and culture methods. Since the production of antibodies in immunocompromised patients is scarce, detection of a specific antigen could be effective for early diagnosis. D-Galactofuranose (Galf) is the antigenic epitope in glycoconjugates of several pathogenic fungi. Since Galf is not biosynthesized by mammals, it is an attractive candidate for diagnosis of infection. A monoclonal antibody that recognizes Galf is commercialized for detection of aspergillosis. The linkage of Galf in the natural glycans and the chemical structures of the synthesized Galf-containing oligosaccharides are described in this paper. The oligosaccharides could be used for the synthesis of artificial carbohydrate-based antigens, not enough exploited for diagnosis.

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Aspergillosis in Surgical Patients

Cited by 5 publications

References 146 publications

AspergillusPericarditis with Tamponade in a Renal Transplant Patient

AspergillusPericarditis with Tamponade in a Renal Transplant Patient

Aspergillus Genus and Its Various Human Superficial and Cutaneous Features

Galactofuranose Antigens, a Target for Diagnosis of Fungal Infections in Humans

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