Aspergillus fumigatus sensitization among asthma COPD overlap patients

El-Shayeb, Mohamed; Ahmed, Noha Othman; Wahba, Nancy Samir; Elsaeed, Mahetab H; ElGwad, Asmaa M Abd; Kamal, Sylvia T

doi:10.55133/eji.280309

Cited by 4 publications

(1 citation statement)

References 26 publications

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“…The pathogenesis of COPD has not been fully elucidated. However, recent studies suggest that imbalance between activities of proteases and antiproteases, as well as oxidative stress, tissue fibrosis and inflammation may be crucial in the pathogenesis of COPD, with abnormal inflammatory response playing a key role in the process [12]. In addition, inflammation is an important factor in immunity against Aspergillus fumigatus infection.…”

Section: Discussionmentioning

confidence: 99%

Regulatory effect of resveratrol on the expressions of factors and surface markers in alveolar macrophages of Aspergillus fumigatus-infected COPD rat model, and the associated mechanism

Du¹,

Huo²,

Liu³

2022

Trop. J. Pharm Res

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Purpose: To study the influence of resveratrol on chronic obstruction in Aspergillus fumigatus infection-induced chronic lung disease (COPD) in rats, and the process involved. Methods: Seventy-five Sprague Dawley SD) rats were assigned to blank control, COPD model, Aspergillus fumigatus-infected COPD model, low (100 mg/kg) and high-dose (200 mg/kg) resveratrol groups, with 15 rats in each group. Enzyme-linked immunosorbent assay (ELISA) was used to assay IL-6, IL-8 and TNF-α in bronchoalveolar lavage fluid (BALF), while lung protein concentrations of AMPK and PGC-1α were assayed by immunoblotting. Results: In low- and high-dose resveratrol groups, inflammatory factor levels were significantly lower than the corresponding levels in COPD model and Aspergillus fumigatus-infected COPD model (p < 0.05), while lung tissue proteins of AMPK, PGC-1α, and AQP5 of the rats given high-dose resveratrol were significantly raised, relative to corresponding levels in rats given low-dose resveratrol (p < 0.05). Conclusion: Resveratrol modulates expression levels of secretory factors and surface markers in alveolar macrophages in COPD model rats infected with Aspergillus fumigatus. Resveratrol exerts this effect through the regulation of AMPK/PGC-1α signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Regulatory effect of resveratrol on the expressions of factors and surface markers in alveolar macrophages of Aspergillus fumigatus-infected COPD rat model, and the associated mechanism

Du¹,

Huo²,

Liu³

2022

Trop. J. Pharm Res

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Prevalence of Aspergillus Sensitization and Allergic Bronchopulmonary Aspergillosis in Adults With Bronchial Asthma: A Systematic Review of Global Data

Agarwal

Muthu

Sehgal

et al. 2023

The Journal of Allergy and Clinical Immunology: In Practice

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Residential exposure toAspergillusspp.is associated with exacerbations in COPD

Tiew,

Leung,

Mac Aogáin

et al. 2024

Eur Respir J

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BackgroundSensitisation toAspergillus fumigatusis linked to worse outcomes in patients with chronic obstructive pulmonary disease (COPD), however, its prevalence and clinical implications in domestic (residential) settings remains unknown.MethodsIndividuals with COPD (n=43) recruited in Singapore had their residences prospectively sampled and assessed by shotgun metagenomic sequencing including indoor air, outdoor air, and touch surfaces (total: 126 specimens). The abundance of environmentalA. fumigatusand the occurrence ofA. fumigatus(Asp f) allergens in the environment were determined and immunological responses toA. fumigatusallergens determined in association with clinical outcomes including exacerbation frequency. Findings were validated in 12 individuals (31 specimens) with COPD in Vancouver, Canada, a climatically different region.Results157 metagenomes from 43 homes were assessed. Eleven and nine separateAspergillus spp.were identified in Singapore and Vancouver respectively. Despite climatic, temperature, and humidity variation,A. fumigatuswas detectable in the environment from both locations. The relative abundance of environmentalA. fumigatuswas significantly associated with exacerbation frequency in both Singapore (r=0.27, p=0.003) and Vancouver (r=0.49, p=0.01) and individuals with higher Asp f 3 sensitisation responses lived in homes with a greater abundance of environmental Asp f 3 allergens (p=0.037). Patients exposed and sensitised to Asp f 3 allergens demonstrated a higher rate of COPD exacerbations at 1-year follow-up (p=0.021).ConclusionEnvironmentalA. fumigatusexposure in the home environment including air and surfaces with resulting sensitisation carries pathogenic potential in individuals with COPD. Targeting domesticA. fumigatusabundance may reduce COPD exacerbations.

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Aspergillus fumigatus sensitization among asthma COPD overlap patients

Cited by 4 publications

References 26 publications

Regulatory effect of resveratrol on the expressions of factors and surface markers in alveolar macrophages of Aspergillus fumigatus-infected COPD rat model, and the associated mechanism

Regulatory effect of resveratrol on the expressions of factors and surface markers in alveolar macrophages of Aspergillus fumigatus-infected COPD rat model, and the associated mechanism

Prevalence of Aspergillus Sensitization and Allergic Bronchopulmonary Aspergillosis in Adults With Bronchial Asthma: A Systematic Review of Global Data

Residential exposure toAspergillusspp.is associated with exacerbations in COPD

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