Aspergillus pneumonia in association with an aspergilloma

Leggat, P.O.; Kretser, D.M.H. De

doi:10.1016/s0007-0971(68)80005-1

Cited by 26 publications

(8 citation statements)

References 11 publications

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“…The results obtained here, however, did not support this concept, but suggested that there might be some kind of invasive process of Aspergillus, which resulted in the appearance of the fungal constituent, (l->3)-(i-D-glucan, in the blood samples. The appearance of (l->3)-p-D-glucan in the blood of patients with aspergil loma was also anticipated as a result of the reports of Leggat and Krctser [ 19] and Rafferty et al [20], in which they showed cases whose aspergilloma developed into invasive aspergillosis. Thus, the present classification of pulmo nary aspergillosis into distinct aspergilloma and invasive aspergillosis might be challenged in the near future.…”

Section: Discussionmentioning

confidence: 82%

Evaluation of the Diagnostic Value of the Measurement of (1→3)-β-D-Glucan in Patients with Pulmonary Aspergillosis

Yuasa

Goto²,

Iguchi³

et al. 1996

Respiration

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The value of the measurement of (1→3)-β-D-glucan, a major and common cell wall constituent of fungi, for diagnosing pulmonary aspergillosis was assessed in comparison with that of conventional examinations. The concentrations of (1→3)-β-D-glucan in sera were elevated in 7 out of 8 patients with active aspergillosis, but not in cases without active diseases, except for one sample. Further, the concentrations well reflected the activity of the aspergillosis in each case. Regarding conventional examinations, with the immunodiffusion test it was difficult to detect the present activity of the disease. The radioallergosorbent test was useful for diagnosing bronchopulmonary aspergillosis, but not for other types of aspergillosis. The Aspergillus-specific component, galactomannan, was insensitive and the enzyme-linked immunosorbent assay gave highly variable results. Thus, although the assessment of the specificity of the assay is still necessary, compared with other tests, the assay of (1→3)-β-D-glucan has the advantage of diagnosing pulmonary aspergillosis and also of assessing the disease activity.

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Section: Discussionmentioning

confidence: 82%

Evaluation of the Diagnostic Value of the Measurement of (1→3)-β-D-Glucan in Patients with Pulmonary Aspergillosis

Yuasa

Goto²,

Iguchi³

et al. 1996

Respiration

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“…In the later case there is a possibility of a continuum of disease from aspergilloma to a chronic necrotising form of disease. Several reports have also documented overlap or continuum of various forms of pulmonary aspergillosis [13, 14]. …”

Section: Discussionmentioning

confidence: 99%

Invasive Pulmonary Aspergillosis

Kristan

Kern²,

Mušič³

2002

Respiration

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Background: Invasive pulmonary aspergillosis usually occurs in immunocompromised patients. Mild abnormality of host defence is usually present in the chronic necrotising form of the disease. Acute aspergillus pneumonia usually affects patients who are seriously immunocompromised. Objectives: The purpose of the study was to highlight the possibility of occurrence of invasive pulmonary aspergillosis also in patients with mild abnormality of host defence. Methods: In a retrospective study 6 patients were analysed. The inclusion criterion was evidence of Aspergillus sp. invasion in lung tissue. Lung tissue was obtained by biopsy or post mortem examination. Results: There were 4 patients with acute aspergillus pneumonia. Two of them were severely immunocompromised – one with dermatomyositis, who was treated with high doses of corticosteroids and methotrexate, and the other with undiscovered miliary tuberculosis, who was treated for myelodysplastic syndrome instead with low doses of corticosteroids. The other 2 had mild immunosuppression: one was suffering from sarcoidosis and was treated with low doses of corticosteroids, the other had dilated cardiomyopathy, renal insufficiency and diabetes mellitus. The two patients with chronic necrotising pulmonary aspergillosis had mild abnormality of host defence: one had reactivation of tuberculosis and diabetes mellitus, the other had inactive tuberculosis and aspergilloma. Conclusions: Invasive pulmonary aspergillosis must be considered also in patients with mild immunosuppression and pulmonary infiltrates which do not respond to conventional treatment with antibiotic chemotherapy. The key to the diagnosis of invasive pulmonary aspergillosis is the histopathological demonstration of fungal invasion in lung tissue.

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“…Although aspergillomas are thought of as an indolent saprophytic growth, cases of subsequent invasive aspergillosis are well described [91,92]. Another linkage is the development of ABPA following the formation of an aspergilloma [93].…”

Section: Issues Of Classification and Overlapmentioning

confidence: 99%

Aspergillus in the lung: diverse and coincident forms

Buckingham

Hansell

2003

Eur Radiol

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Pulmonary disease caused by the fungus Aspergillus has traditionally been regarded as belonging to one of the following, apparently distinct, entities: saprophytic aspergilloma; allergic bronchopulmonary aspergillosis (ABPA); and invasive aspergillosis (IPA); which may be further categorised as angioinvasive, acute or chronic airway invasive) [1]. It is not always obvious that there is overlap between these entities, and that in any given patient more than one Aspergillus-related pathological process can co-exist [2]. The aim of this article is to review the clinical and imaging features of the main categories of Aspergillus-related pulmonary disease and, in particular, to highlight the overlap between them.

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Aspergillus pneumonia in association with an aspergilloma

Cited by 26 publications

References 11 publications

Evaluation of the Diagnostic Value of the Measurement of (1→3)-β-D-Glucan in Patients with Pulmonary Aspergillosis

Evaluation of the Diagnostic Value of the Measurement of (1→3)-β-D-Glucan in Patients with Pulmonary Aspergillosis

Invasive Pulmonary Aspergillosis

Aspergillus in the lung: diverse and coincident forms

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