AimsMedicinal plants have a long and significant history of being used for their healing properties. One famous example is Commiphora, which is mostly found in the southern part of Arabia. The objective of this research was to evaluate the effectiveness of a water-based extract obtained from two different varieties of myrrh in suppressing the proliferation ofCandidaspp. at different concentrations. The objective of this research is to determine the chemical composition ofCommiphoraand its capacity to prevent the development ofCandidaspp.Methodology and ResultsA plant specimen traditionally used in Saudi Arabia for its possible effectiveness againstCandida albicans(ATCC 14053),C. neoformans(ATCC 66031),Candida laurentii(ATCC 18803),Candida guilliermondii(ATCC 6260), andCandida tropicalis(ATCC 66029). The results showed that the aqueous extract of both tested species of Myrrha (Commiphora myrrhaandC. molmol) shown inhibitory effects on all tested isolates. Moreover, it was discovered that the inhibitory impact decreased with increasing concentrations of Myrrha. During the chemical examination of the Myrrha, it was noted that the material included 12 components known for their antimicrobial properties. The components described before are as follows: The specified chemical compounds consist of β-Elemene, β-bisabolene, Dihydro butyl bezodoxepin, Tetradecanol, methyl palmitate, Tribenzo-1,2,3,4,5,6 anthracene, 9-Eicosene, 2-bromo-4-fluoro-N-(thiophen-2-ylmethyl) aniline, Octadecenoic acid methyl ester, dehydroabietic acid, and Docosene.ConclusionThe antimicrobial activity of five yeasts was assessed using the diffusion technique. The essential oil derived from two varieties of myrrha shown the most significant effects onCandida tropicalis(ATCC 66029),Candida guilliermondii(ATCC 6260),Candida laurentii(ATCC 18803),C. neoformans(ATCC 66031), andCandida albicans(ATCC 14053). Upon conducting a chemical examination of the myrrha, it was shown that it consists of 19 known components, of which 12 compounds have been proven by research to suppress the growth of microorganisms. Further research is needed to fully explore the potential of these water extracts as innovative antifungal medicines, including their effectiveness against various strains ofCandidaand the processes by which they work, as well as the primary components responsible for their action.
