Asperosaponin VI protects mice from sepsis by regulating Hippo and Rho signaling pathway

Pang, Caixia; Wen, Cailing; Liang, Yanxiang; Luo, Huiyang; Wei, Linlin; Liu, Haiqian; Qin, Tian; Tan, Huijing; He, Chonghua; Liu, Ying; Yang, Chen; Zeng, Sha; Zhou, Chun

doi:10.1016/j.phymed.2022.154010

Cited by 9 publications

(4 citation statements)

References 28 publications

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“…Additionally, studies have shown its ability to stimulate osteoblast proliferation and exhibit anti‐inflammatory effects, suggesting potential applications in osteoporosis and arthritis treatment 16,17 . Our previous studies also indicated that ASA VI hindered osteoclast formation and mitigated inflammation and organ damage from sepsis via regulation of the mitogen‐activated protein kinase and Rho GTPase subtype C–Hippo pathways 18,19 . However, the role of ASA VI in skeletal muscle regeneration remains unknown.…”

Section: Introductionmentioning

confidence: 94%

“…16,17 Our previous studies also indicated that ASA VI hindered osteoclast formation and mitigated inflammation and organ damage from sepsis via regulation of the mitogen-activated protein kinase and Rho GTPase subtype C-Hippo pathways. 18,19 However, the role of ASA VI in skeletal muscle regeneration remains unknown. This study aims to investigate the potential benefits of ASA VI on muscle regeneration using a cardiotoxin (CTX)-induced skeletal muscle injury mouse model and to elucidate the underlying mechanism of ASA VI's protective effect against apoptosis and autophagy.…”

Section: Introductionmentioning

confidence: 99%

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Asperosaponin VI facilitates the regeneration of skeletal muscle injury by suppressing GSK‐3β‐mediated cell apoptosis

Yang,

Liang,

Shu

et al. 2023

J of Cellular Biochemistry

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Asperosaponin VI (ASA VI) is a bioactive triterpenoid saponin extracted from Diptychus roots, of Diptyl, and has previously shown protective functions in rheumatoid arthritis and sepsis. This study investigates the effects and molecular mechanisms of ASA VI on skeletal muscle regeneration in a cardiotoxin (CTX)‐induced skeletal muscle injury mouse model. Mice were subjected to CTX‐induced injury in the tibialis anterior and C2C12 myotubes were treated with CTX. Muscle fiber histology was analyzed at 7 and 14 days postinjury. Apoptosis and autophagy‐related protein expression were evaluated t s by Western blot, and muscle regeneration markers were quantified by quantitative polymerase chain reaction. Docking studies, cell viability assessments, and glycogen synthase kinase‐3β (GSK‐3β) activation analyses were performed to elucidate the mechanism. ASA VI was observed to improve muscle interstitial fibrosis, remodeling, and performance in CTX‐treated mice, thereby increased skeletal muscle size, weight, and locomotion. Furthermore, ASA VI modulated the expression of apoptosis and autophagy‐related proteins through GSK‐3β inhibition and activated the transcription of regeneration genes. Our results suggest that ASA VI mitigates skeletal muscle injury by modulating apoptosis and autophagy via GSK‐3β signaling and promotes regeneration, thus presenting a probable therapeutic agent for skeletal muscle injury.

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Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Asperosaponin VI facilitates the regeneration of skeletal muscle injury by suppressing GSK‐3β‐mediated cell apoptosis

Yang,

Liang,

Shu

et al. 2023

J of Cellular Biochemistry

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Section: Signaling Pathways Related To Pdac 4 -Induced Spleen Toxicitymentioning

confidence: 99%

“…The Hippo signaling pathway regulates in ammatory responses, morphological structure, cell survival, proliferation, differentiation, and migration in the spleen [32][33][34]. Treatment with asperosaponin VI has been shown to alleviate sepsis-induced spleen histopathology changes, reduce in ammatory responses by inhibiting Hippo and Rho signaling pathways [32]. Hippo signaling pathway-associated proteins MST1 and MST2 are essential for follicular B cells to generate marginal zone B cells by regulating their recirculation and migration toward the splenic red pulp [33].…”

Section: Signaling Pathways Related To Pdac 4 -Induced Spleen Toxicitymentioning

confidence: 99%

Identification of the Hub Genes Linked to Lead (IV)-Induced Spleen Toxicity Using the Rat Model

Yang,

Wang,

et al. 2023

Biol Trace Elem Res

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Exposure to lead (Pd) can have harmful effects on the organs of both humans and animals, particularly the spleen. However, the precise mechanisms through which Pd (IV) exposure leads to spleen toxicity remain unclear. Hence, this study aimed to identify the key genes and signaling pathways involved in spleen toxicity caused by Pd (IV) incubation. We obtained the dataset GSE59925 from the Gene Expression Omnibus, which included spleen samples treated with lead tetraacetate (PdAc4) as well as control samples on the 1st and 5th day after PdAc 4 exposure. Through differential expression analysis, we identi ed 607 and 704 differentially expressed genes (DEGs) in the spleens on the 1st and 5th day following PdAc 4 treatment, respectively, with 245 overlapping DEGs between the two time points. Gene ontology analysis revealed that the commonly shared DEGs were primarily involved in signal transduction, drug response, cell proliferation, adhesion, and migration. Pathway analysis indicated that the common DEGs were primarily associated with MAPK, TNF, cAMP, Hippo, and TGF-β signaling pathways. Furthermore, we identi ed hub genes such as CXCL10, PARP1, APOE, and VDR that contribute to PdAc 4 -induced spleen toxicity. This study enhances our understanding of the molecular mechanisms underlying Pd (IV) toxicity in the spleen.

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Natural products: A potential immunomodulators against inflammatory-related diseases

Sai Priya,

Ramalingam,

Suresh Babu

2024

Inflammopharmacol

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Asperosaponin VI protects mice from sepsis by regulating Hippo and Rho signaling pathway

Cited by 9 publications

References 28 publications

Asperosaponin VI facilitates the regeneration of skeletal muscle injury by suppressing GSK‐3β‐mediated cell apoptosis

Asperosaponin VI facilitates the regeneration of skeletal muscle injury by suppressing GSK‐3β‐mediated cell apoptosis

Identification of the Hub Genes Linked to Lead (IV)-Induced Spleen Toxicity Using the Rat Model

Natural products: A potential immunomodulators against inflammatory-related diseases

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