Asphyxia Following Injection of Tartar Emetic.

Fakhry, A.

doi:10.1016/s0140-6736(00)99716-2

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the systematic use of antimony in modern medicine can be attributed to Plimmer and Thomson, who used it to treat African trypanosomiasis [321]. Soon, the side effects of antimonial drugs, which include but are not limited to headache, nausea, vomiting, diarrhea, ache in the muscles and joints, coughing and syncopes, and anaphylaxis, became apparent [322]. Interestingly, there is a single, apparently positive report, in using antimonials to treat syphilis [323].…”

Section: Use Of Antimony In Medicinementioning

confidence: 99%

Availability, Toxicology and Medical Significance of Antimony

Periferakis

Căruntu

Periferakis

et al. 2022

IJERPH

View full text Add to dashboard Cite

Antimony has been known and used since ancient times, but its applications have increased significantly during the last two centuries. Aside from its few medical applications, it also has industrial applications, acting as a flame retardant and a catalyst. Geologically, native antimony is rare, and it is mostly found in sulfide ores. The main ore minerals of antimony are antimonite and jamesonite. The extensive mining and use of antimony have led to its introduction into the biosphere, where it can be hazardous, depending on its bioavailability and absorption. Detailed studies exist both from active and abandoned mining sites, and from urban settings, which document the environmental impact of antimony pollution and its impact on human physiology. Despite its evident and pronounced toxicity, it has also been used in some drugs, initially tartar emetics and subsequently antimonials. The latter are used to treat tropical diseases and their therapeutic potential for leishmaniasis means that they will not be soon phased out, despite the fact the antimonial resistance is beginning to be documented. The mechanisms by which antimony is introduced into human cells and subsequently excreted are still the subject of research; their elucidation will enable us to better understand antimony toxicity and, hopefully, to improve the nature and delivery method of antimonial drugs.

show abstract

Section: Use Of Antimony In Medicinementioning

confidence: 99%