Aspidosperma–aspidosperma-type bisindole alkaloids from Voacanga africana

Simple indole alkaloids and those with a nonrearranged monoterpenoid unit

“…45). 288 Two new alkaloids, mekongenines A (919) and B (920), were isolated from the MeOH extract of twigs and leaves of Bousigonia mekongen distributed in southern China, Laos, and Vietnam. Compound 919 showed moderate cell growth inhibitory activity against ve human cell lines (Fig.…”

Compounds with Anti-Onchocercal Activity from Voacanga africana Stapf (Apocynaceae): Identification and Molecular Modeling

“…A new bisindole iboga-vobasine type alkaloid named voacamine A (1) along with eight known compounds, voacangine (2), voacristine (3), coronaridine (4), tabernanthine (5), ibogaine (6), voacamine (7), voa corine (8), and conoduramine (9) were isolated from the stem barks of Voacanga africana. All compounds were tested for their anti-Onchocercal activity against the O. ochengi.…”

“…The crude methanol extract of V. africana was subjected to silica gel normal phase open column chromatography and elution with a gradient of ethyl acetate in hexane. Repeated column chromatography through Sephadex LH-20, preparative thin-layer chromatography (TLC) yielded a new bisindole alkaloid derivative named voacamine A (1) along with eight known compounds, voacangine (2), voacristine (3),coronaridine (4), tabernanthine (5), iboxygaine (6), voacamine (7), voacorine (8), and conoduramine (9) [16][17][18][19][20][21][22][23][24][25] (Figure 1). The structures of the compounds were established based on NMR ( Figures S3-S25) analyses as well as by comparison with published data.…”

“…For example, the root bark of the plant is used to treat diarrhoea in Kinshasa, the Democratic Republic of Congo [1], while the stem bark has been used in combination with the sister species V. thouarsii in the treatment of heart disease, leprosy, diarrhoea, generalized oedema, madness and convulsions in children in Ivory Coast, Cameroon, Ghana and Congo [2,3]. Additionally, the fruits, bark and leaf extracts have been used in Cameroonian ethnomedicine to treat orchitis, ectopic testes and gonorrhoea, respectively [4][5][6][7][8]. Of late, Apocynaceous plants have been under scientific investigation.…”

Alkaloids with Anti-Onchocercal Activity from Voacanga africana Stapf (Apocynaceae): Identification and Molecular Modeling

“…For example, the root bark of the plant is used to treat diarrhea in Kinshasa, the Democratic Republic of Congo [ 1 ], while the stem bark has been used in combination with the sister species V. thouarsii in the treatment of heart disease, leprosy, diarrhea, generalized oedema, madness and convulsions in children in Ivory Coast, Cameroon, Ghana and Congo [ 2 , 3 ]. Additionally, the fruits, bark and leaf extracts have been used in Cameroonian ethnomedicine to treat orchitis, ectopic testes and gonorrhoea, respectively [ 4 , 5 , 6 , 7 , 8 ]. Of late, Apocynaceous plants have been under scientific investigation.…”